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| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | Liver bioengineering:Current status and future perspectives显示文摘The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes.There are two general pathways to liver bioengineering and regeneration.The first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in vivo.This strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human origin.Liver bioengineering has potential for transplantation and for toxicity testing during preclinical drug development.The second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell pathways.In fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver volume.Infusion of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine strategies.As well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate. | Christopher Booth Tom Soker Pedro Baptista Christina L Ross Shay Soker Umar Farooq Robert J Stratta Giuseppe Orlando | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 3 | Diet and fecal lipids following cholecystectomy in men显示文摘 | BRYDON W G ROSS M C L ANDERSON J R | 1982 | Digestion1982，25，： | 1 |
| 4 | Review of strain rate effects for concrete in tension显示文摘 | Malvar L J Ross CA | 1998 | ACI Matreials Journal1998，95，6： | 1 |
| 5 | Average magnitude difference function pitch extractor显示文摘 | ROSS M J SHAFFER H L COHEN A | 1974 | IEEE Trans on Acoustics Speech and Signal Processing1974，22，5： | 1 |
| 6 | Numerical simulation of high strain rate concrete compress test 显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Struc- tures1994，51，1： | 1 |
| 7 | Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione显示文摘 | LOPACHIN R M ROSS J F REID M L | 2002 | Neurotoxicology2002，23，1： | 1 |
| 8 | Heart rate and blood pressure changes during gastroscopy in healthy older subjects显示文摘 | NEWTON J L | 2004 | Gerontology2004，50，3： | 1 |
| 9 | Numerical simu-lation of high strain rate concrete compression tests显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Structures1994，51，1： | 1 |
| 10 | Selective ex- pression in carotid body lype l ceils of a single sphce variant of the large conductance calcium- and voltage-activated pates-sium channel confers regulation by AMP-activaled protein ki- nase显示文摘 | ROSS F A RAFFEBTY J N DALLAS M L et el | 2011 | J Biol Chem2011，286，11： | 1 |
| 11 | Occupation of biological space during seedling establishment显示文摘 | Ross M A Harper J L | 1972 | Journal of Ecology1972，60，： | 1 |
| 12 | The effect ofGibbs adsorption on Marangoni instability in penetration mass transfer显示文摘 | Brian P L T Ross J R | 1972 | AIChE J1972，18，： | 1 |
| 13 | A Strain-rate-dependent concrete material model for ADINA显示文摘 | Tedesco J W Powell J C Ross C Hughes M L | 1997 | Computers & Structures1997，64，56： | 1 |
| 14 | Lifestyle Physical Activity Interventions: History, Short- and Long-term Effects, and Recommendations显示文摘 | Andrea L D Ross E A John M J | 1998 | American Journal of Preventive Medicine1998，15，4： | 1 |
| 15 | Multi- plexed protein quantitation in Socchoromyces cerevisioe using amine-reactive isobaric tagging reagents 显示文摘 | ROSS P L HUANG Y N MARCHESE J N | 2004 | Mol Cell Pro- teomics2004，3，12： | 1 |
| 16 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 17 | Review of strain rate effect for concrete in tension显示文摘 | Malvar L J Ross C A | 1998 | ACI Materials Journal1998，95，6： | 1 |
| 18 | Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure显示文摘 | Austin J Williams R Ross L | 2005 | Eur J Heart Fail2005，7，3： | 1 |
| 19 | Promoter characterization and genomic organization of the human breast cancer resistance protein ( ATP-binding cassette transporter G2 ) gene 显示文摘 | Bailey-Dell K J Hassel B Doyle L A Ross D D | 2001 | Biochim Biophys Acta2001，1520，3： | 1 |
| 20 | PR-39,a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox显示文摘 | Shi J Ross C R Loto T L | 1996 | Proc Natl Acad Sci USA1996，93，12： | 1 |
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