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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 3 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 4 | Various behavioral signs of estrus and their relationship with time of ovulation in dairy cattle显示文摘 | Roelofs J B van Eerdenburg F J C M Soede N M | 2005 | Theriogenology2005，63，5： | 1 |
| 5 | Scan time and patient dose for thoracic imaging in neonates and small children using axial volumetric320-detector row CT compared to helical 64-,32-,and 16-detector row CT acquisitions显示文摘 | Kroft LJ Roelofs JJ Geleijns J | 2010 | Pediatr Radiol2010，40，： | 1 |
| 6 | An MEG study of picture naming 显示文摘 | Leveh W J M Roelofs A Meyer A S | 1998 | Journal of Cognitive Neuroscience1998，10，5： | 1 |
| 7 | Scan time and patient dose for thoracic imaging in neonates and small children using axial volumetric 320-detector row CT compared to helical 64-, 32-, and 16-detector row CT acquisitions显示文摘 | Kroft L J Roelofs J J Geleijns J | 2010 | Pediatr Radiol2010，40，： | 1 |
| 8 | The effects of airborne nitrogen pollutants on species diversity in natural and semi natural European vegetation显示文摘 | Bobbink R Hornung M Roelofs J G M | 1998 | Ecology1998，86，： | 1 |
| 9 | Fear of move- ment and (re) injury in chronic musculoskeletaI pain:Eviden- ce for an invariant two-factor model of the Tampa Scale for Kinesiophobia across pain diagnoses and Dutch,Swedish,and Canadian samples 显示文摘 | Roelofs J Sluiter JK Frings-Dresen MH | 2007 | Pain2007，131，12： | 1 |
| 10 | Sulphate - mediated iron limitation and eutrophication in aquatic ecosystems显示文摘 | Smolders A Roelofs J G M | 1993 | Aquat Bot1993，46，： | 1 |
| 11 | Sex pheromone titer correlated with pheromone gland development and age in the redbanded leafroller moth, Argyrotaenia velutinana显示文摘 | MILLER J R ROELOFS W L | 1977 | Annals of the Entomological Society of America1977，70，1： | 1 |
| 12 | Effects of intraduodenal bile on interdigestive gastrointestinal and gallbladder motility in healthy subjects显示文摘 | Luiking Y C Kloppers N J Roelofs J M et a1 | 2001 | Digestion2001，63，3： | 1 |
| 13 | The effects of air-borne nitrogen pollutants on species diversity in natural and semi-natural European vegetation 显示文摘 | Bobbink R Hornung M Roelofs J G M | 1998 | Journal of Ecology1998，86，： | 1 |
| 14 | Differential sensitivity of green algae to allelopathic substances from Chara显示文摘 | Mulderij G Van Donk E Roelofs J G M | 2003 | Hydrobiologia2003，491，13： | 1 |
| 15 | Correlates of Self-reported Attach ment (In)security in Children:The Role of Parental Romantic Attachment Status and Rearing Behaviors显示文摘 | Roelofs J Meesters C Muris P | | 0，，： | 1 |
| 16 | The effects of airborne nitrogen pollutants on species diversity in natural and semi natural European vegetation 显示文摘 | Bobbink R Homung M Roelofs J | 1998 | Ecology1998，86，： | 1 |
| 17 | A Theory of Lex- ieal Aaeeess in Speech Production显示文摘 | Levelt W J M Roelofs A Meyer A S | 1999 | Behavioral and Brain Sciences1999，，22： | 1 |
| 18 | The Effects of Social Stress and Cortisol Responses on the Preconscious Selective Attention to Social Threat显示文摘 | ROELOFS K BAKVIS P HERMANS E J | | 0，，01： | 1 |
| 19 | Renal expression of CD44 correlates with acute renal al-lograft rejection显示文摘 | ROUSCHOP K M ROELOFS J J SYLVA M | 2006 | Kidney Int2006，70，6： | 1 |
| 20 | DD3(PCA3), a very sensitive and specific marker to detect prostate tumors 显示文摘 | de Kok J B Verhaegh G W Roelofs R W | 2002 | Cancer Res2002，62，9： | 1 |
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