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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Choroidal vesselsalterations in treated and untreated diabetic rats显示文摘 | Rodrigues AC Schellini SA Spadela CT | 2007 | Arq BrasOftalmol2007，70，： | 1 |
| 3 | Implications of volatile fatty acid profile on the metabolic pathway during continu- ous sulfate reduction 显示文摘 | Bertolino SM Rodrigues ICB Guerra - Sa R | 2012 | Journal of Environmental Management2012，103，： | 1 |
| 4 | Spontaneous Coronary Artery Dissection with Clinical Presentation of Acute Myocardial Infarction显示文摘 | Taísa Godoy Guzzela Luciano de Siqueira Bracci Júnior Mauro Rogério de Barros Wanderley Júnior Sandra Helena Gonsalves de Andrade Mauro Cosme Gomes de Andrade Raony Previtali Paniquar Izabela Guimaraes Falcao Alves Nayrelle de Alencar Ferreira Gomes Jandir Ferreira Gomes Júnior Marcela Lopes Muniz de Andrade Renata London Rodrigues Diego Silveira da Costa Lucila Buriasco de Oliveira Amanda Ribeiro Letícia Trad Martins Costa Diego Braga Filartiga Reiby Caetano Mustafá | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
| 5 | Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimerμs Disease显示文摘 | Maria Cecilia Rodrigues Simoes Flavia Pereira Dias Viegas Marcella Soares Moreira Matheus de Freitas Silva Mariana Maximo Riquiel Patricia Mattos da Rosa Maísa Rosa Castelli Marcelo Henrique dos Santos Marisi Gomes Soares Claudio Viegas | 2014 | Mini-Reviews in Medicinal Chemistry2014，，1： | 1 |
| 6 | Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta显示文摘 | Felipe SA Rodrigues ES Marein RP | 2007 | J Med Biol Res2007，40，： | 1 |
| 7 | Eyelid entropion 显示文摘 | Pereira MG Rodrigues MA Rodrigues SA | 2010 | Semin Ophthalmol2010，25，3： | 1 |
| 8 | Nucleon Finite Volume Effect and Nuclear Matter Properties in a Relativistic Mean-Field Theory显示文摘 | R. Costa A.J. Santiago H. Rodrigues J. Sa Borges | 2006 | Communications in Theoretical Physics2006，46，6X： | 1 |
| 9 | Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice显示文摘 | Silva CL Bonato VL Coelho-Castelo AA Souza1 AD Santos1 SA Lima1 KM Faccioli LH Rodrigues JM | 2005 | Gene Ther2005，12，3： | 1 |
| 10 | Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice显示文摘 | Silva CL Bonato VL Coelho-Castelo AA De Souza AO Santos SA Lima KM Faccioli LH Rodrigues JM | 2005 | Gene Ther2005，12，3： | 1 |
| 11 | Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity:a canonical analysis显示文摘 | OLIVEIRA JUNIOR SA PADOVANI CR RODRIGUES SA | 2013 | Cardiovasc Diabetol2013，12，1： | 1 |
| 12 | Mild hypercholes- terolemia blunts the proinflammatory and prothrombotlc effects of hypertensionon the cerebral microcirculation显示文摘 | Rodrigues SF Vital SA Granger DN | 2013 | J Cereb Blood Flow Metab2013，33，4： | 1 |
| 13 | Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways显示文摘BACKGROUND Chronic Hepatitis C(CHC)affects 71 million people globally and leads to liver issues such as fibrosis,cirrhosis,cancer,and death.A better understanding and prognosis of liver involvement are vital to reduce morbidity and mortality.The accurate identification of the fibrosis stage is crucial for making treatment decisions and predicting outcomes.Tests used to grade fibrosis include histological analysis and imaging but have limitations.Blood markers such as molecular biomarkers can offer valuable insights into fibrosis.AIM To identify potential biomarkers that might stratify these lesions and add information about the molecular mechanisms involved in the disease.METHODS Plasma samples were collected from 46 patients with hepatitis C and classified into fibrosis grades F1(n=13),F2(n=12),F3(n=6),and F4(n=15).To ensure that the identified biomarkers were exclusive to liver lesions(CHC fibrosis),healthy volunteer participants(n=50)were also included.An untargeted metabolomic technique was used to analyze the plasma metabolites using mass spectrometry and database verification.Statistical analyses were performed to identify differential biomarkers among groups.RESULTS Six differential metabolites were identified in each grade of fibrosis.This six-metabolite profile was able to establish a clustering tendency in patients with the same grade of fibrosis;thus,they showed greater efficiency in discriminating grades.CONCLUSION This study suggests that some of the observed biomarkers,once validated,have the potential to be applied as prognostic biomarkers.Furthermore,it suggests that liquid biopsy analyses of plasma metabolites are a good source of molecular biomarkers capable of stratifying patients with CHC according to fibrosis grade. | Adriana Camargo Ferrasi Samara Vitória Granja Lima Aline Faria Galvani Jeany Delafiori Flavia Luísa Dias-Audibert Rodrigo Ramos Catharino Giovanni Faria Silva Roberta Rodrigues Praxedes Driele Bretones Santos Dayane Trevisan de Macedo Almeida Estela Oliveira Lima | 2023 | World Journal of Hepatology2023，15，11： | 1 |
| 14 | Eyelid entropion显示文摘 | Pereira MG Rodrigues MA Rodrigues SA | 2010 | Semin Ophthalmol2010，25，3： | 1 |
| 15 | Nutrient balance of shifting cultivation by burning or mulching in the Eastern Amazon evidence for subsoil nutrient accumulation显示文摘 | SOMMER R VLEK P L G DE ABREU SA TD VIELHAUER K DE FATIMA RODRIGUES COELHO R FOLSTER H | 2004 | Nutrient Cy- cling in Agroecosystems2004，68，： | 1 |
| 16 | Landau-Kleffner syndrome : study of four cases 显示文摘 | Santos LH Antoniuk SA Rodrigues M | 2002 | Arq Neuropsiquiatr2002，60，2： | 1 |
| 17 | Micromechanics of annulus-end plate integration in the intervertebral disc显示文摘 | Rodrigues SA Wade KR Thambyah A | | 0，，02： | 1 |
| 18 | Influence of surface treatments on the bond strength of repaired resin composite restorative materials显示文摘 | Rodrigues SA Jr Ferracane JL Della BA | 2009 | Dent Mater2009，25，4： | 1 |
| 19 | Antimicrobial activity of broth fermented with kefir grains 显示文摘 | Silva KR Rodrigues SA Xavier Filho L | 2009 | Ap- plied Biochemistry and Biotechnology2009，152，2： | 1 |
| 20 | Eyelid entropi- on 显示文摘 | Pereira MG Rodrigues MA Rodrigues SA | 2010 | Semin Ophthalmol2010，25，3： | 1 |
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