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| 1 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 2 | No Signs of New Toxicity When Amphotericin B Lipid Complex (ABLC,ABELCET)and Caspofungin Are Used in Combination in the Treatment of FUO显示文摘 | Rodrigo Martino Bertrand Dupont Helen Huckle | 2004 | Blood (Ash Annual Meeting Abseracts)2004，104，11： | 1 |
| 3 | No signs of new toxicity when amphotericin B lipid complex (ABLC ,ABELCET)and caspofungin are used in combination in the treatment of FUO 显示文摘 | RODRIGO MARTINO BERTRAND DUPONT HELEN HUCKLE | 2004 | Bood ( Ash Annual Meeting Abseracts )2004，104，11： | 1 |
| 4 | Air-leak Syndromes in Hematopoietic Stem Cell Transplant Recipients With Chronic GVHD: High-resolution CT Findings显示文摘 | Tomás Franquet Sonia Rodríguez José M. Hernández Rodrigo Martino Ana Giménez Alberto Hidalgo Pere Domingo | 2007 | Journal of Thoracic Imaging2007，，4： | 1 |
| 5 | Clinical and economic impact of procalcitonin to shorten antimicrobial therapy in septic patients with proven bacterial infection in an intensive care setting显示文摘 | Rodrigo Octavio Deliberato Alexandre R. Marra Paula Rodrigues Sanches Marines Dalla Valle Martino Carlos Eduardo dos Santos Ferreira Jacyr Pasternak Angela Tavares Paes Lilian Moreira Pinto Oscar Fernando Pav?o dos Santos Michael B. Edmond | 2013 | Diagnostic Microbiology & Infectious Disease2013，，3： | 1 |
| 6 | lnvasive pulmonary aspergillosis in patients with hematologic malignancies: survival and prognostic factors 显示文摘 | Maricel Subira Rodrigo Martino Tomas Franquet | 2002 | Haematologica2002，87，4： | 1 |
| 7 | Living-donor liver transplantation in Budd-Chiari syndrome with inferior vena cava complete thrombosis:A case report and review of the literature显示文摘BACKGROUND Budd-Chiari syndrome(BCS)is a challenging indication for liver transplantation(LT)due to a combination of massive liver,increased bleeding,retroperitoneal fibrosis and frequently presents with stenosis of the inferior vena cava(IVC).Occasionally,it may be totally thrombosed,increasing the complexity of the procedure,as it should also be resected.The challenge is even greater when performing living-donor LT as the graft does not contain the retrohepatic IVC;thus,it may be necessary to reconstruct it.CASE SUMMARY A 35-year-old male patient with liver cirrhosis due to BCS and hepatocellular carcinoma beyond the Milan criteria underwent living-donor LT with IVC reconstruction.It was necessary to remove the IVC as its retrohepatic portion was completely thrombosed,up to almost the right atrium.A right-lobe graft was retrieved from his sister,with outflow reconstruction including the right hepatic vein and the branches of segment V and VIII to the middle hepatic vein.Owing to massive subcutaneous collaterals in the abdominal wall,venovenous bypass was implemented before incising the skin.The right atrium was reached via a transdiaphragramatic approach.Hepatectomy was performed en bloc with the retrohepatic vena cava.It was reconstructed with an infra-hepatic vena cava graft obtained from a deceased donor.The patient remains well on outpatient clinic follow-up 25 mo after the procedure,under an anticoagulation protocol with warfarin.CONCLUSION Living-donor LT in BCS with IVC thrombosis is feasible using a meticulous surgical technique and tailored strategies. | Vinicius Rocha-Santos Daniel Reis Waisberg Rafael Soares Pinheiro Lucas Souto Nacif Rubens Macedo Arantes Liliana Ducatti Rodrigo Bronze Martino Luciana Bertocco Haddad Flavio Henrique Galvao Wellington Andraus Luiz Augusto Carneiro-D'Alburquerque | 2021 | World Journal of Hepatology2021，13，1： | 1 |
| 8 | Pigmented well-differentiated hepatocellular neoplasm with β-catenin mutation显示文摘According to the most recent WHO classification of hepatocellular adenomas,a small percentage of inflammatory hepatocellular adenomas presents with mutation in the β-catenin gene and are at higher risk of malignant transformation. It has been recognized that adenoma-like hepatocellular neoplasms with focal atypia,or in unusual clinical context present with similar cytogenetic and immunohistochemistry characteristics to well-differentiated hepatocellular carcinomas. We report a case of a well-differentiated hepatocellular neoplasm with Dubin-Johnson-like pigment displaying histological features overlapping with a β-catenin mutated inflammatory adenoma and a well-differentiated hepatocellular carcinoma in a non-cirrhotic liver. The patient was a 48-year-old woman,who was asymptomatic,and had a clinical history of intra-uterine exposure to diethylstilbestrol,previous cancers and past oral contraceptive use. The recently proposed term 'well-differentiated hepatocellular neoplasm of uncertain malignant potential' should be applied in such cases to highlight the different pathogenesis and risk of malignancy compared to the typical adenomas,and to suggest a careful and customized clinical management. | Lara Neves Souza Rodrigo Bronze de Martino Richard Thompson Sandra Strautnieks Nigel D Heaton Alberto Quaglia | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 0 |
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