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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Acute pancreatitis and COVID-19:A literature review显示文摘BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the ongoing pandemic of coronavirus disease 2019(COVID-19),and has caused more than 80 million infections and 1.7 million deaths worldwide.Although it is primarily a respiratory virus,SARS-CoV-2 also has extra-pulmonary effects.Pancreatic injury and cases of acute pancreatitis(AP)have been recognized and attributed to SARS-CoV-2,but the mechanisms of pancreatic injury are still a subject of debate.There is also controversy on whether SARS-CoV-2 can cause AP or if it is an epiphenomenon.AIM To review and to explore the relationship between SARS-CoV-2 infection and AP,and to provide an overview of the existing literature on possible mechanisms of SARS-CoV-2-induced pancreatic lesion.METHODS A systematic review was conducted in accordance with PRISMA guidelines for papers on SARS-CoV-2 infection and AP.A narrative review on possible mechanisms of SARS-CoV-2-induced pancreatic lesion was also performed.RESULTS A literature review revealed a growing body of evidence on SARS-CoV-2-induced pancreatic lesions including the mechanisms of direct virus-mediated injury,systemic inflammatory response and circulating pro-inflammatory interleukins,virus-induced lipotoxicity,and drug-induced injury.A systematic review of the literature revealed 22 cases of AP in COVID-19 patients.However,limitations of the reported cases make it difficult to establish a causal relationship between SARS-CoV-2 infection and AP.All of the studies agreed on special monitoring and surveillance of this subset of patients due to the still unknown clinical progression,therapeutic implications,and prognosis.CONCLUSION AP should be considered in COVID-19 patients,especially in those exhibiting abdominal pain and systematic,and complete reporting of these cases should be general practice.However,there is still insufficient evidence showing that COVID-19 can cause AP or negatively impact prognosis.Additional studies are needed to clarify the relationship between these two entities and their theragnostic significance. | Tiago Correia de Sá Carlos Soares Mónica Rocha | 2021 | World Journal of Gastrointestinal Surgery2021，13，6： | 2 |
| 4 | Controlling hydrolysis and dispersion of AlN powders in aqueous media显示文摘 | OLIVEIRA M OLHERO S ROCHA J | 2003 | J Colloid Interface Sci2003，261，： | 1 |
| 5 | 显示文摘 | Donida M W Rocha S C S | 2002 | Drying Technology2002，20，3： | 1 |
| 6 | Treatment by Splenectomy of a Portal Vein Aneurysm in Hepatosplenic Schistosomiasis显示文摘 | Mucenic M Rocha Md Mde S Laudanna AA | 2002 | Rev Inst Med Trop Sao Paulo2002，44，5： | 1 |
| 7 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 8 | Preparation and characterization of affinity magnetoliposomes useful for the detection of antiphospholipid antibodies显示文摘 | ROCHA F M DE PINDO S C ZOLLERATION R L | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 9 | Controlling hydrolysis and dispersion of AlN powders in aqueous media 显示文摘 | Oliveira M Olhero S Rocha J | 2003 | Journal of Colloid and Interface Science2003，261，： | 1 |
| 10 | Speciation of mercury using capillary electrophoresis coupled to volatile species generation-inductively coupled plasma mass spectrometry 显示文摘 | ROCHA M S SOLDADO A B BLANCO E | 2001 | J Anal At Spectom2001，，16： | 1 |
| 11 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 12 | Oil sludge treatment by photocatalysis applying black and white light显示文摘 | ROCHA O R S DANTAS R F DUARTE M M M B | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 13 | The use of software product lines for business process management:a systematic literature review显示文摘 | ROCHA R S FANTINATO M | 2013 | Information and Software Technology2013，55，8： | 1 |
| 14 | Needs of nursing guidance for self-care of clients on hemodialysis therapy 显示文摘 | Dos S I Rocha R P Berardinelli L M | 2011 | Rev Bras Enferm2011，64，2： | 1 |
| 15 | Lipase immobilization onto polymeric membrance 显示文摘 | CARNERIRO-da-CUNDA M C ROCHA J M S GARCIA F A P | 1979 | Biotechnol Techniques1979，13，： | 1 |
| 16 | A comparison of proper orthngonal decomposition and Mote Carlo simulation of wind pressure data显示文摘 | Rocha M M Cabral S V S Riera J D | 2000 | Journal of Wind Engineering Industrial Aerodynamics2000，84，： | 1 |
| 17 | Fluid dynamics study of the influence of the position of the feed in fabric filters 显示文摘 | Rocha S M S Vieira L G M Aguiar M L | 2009 | Computer Aided Chemical Engineering2009，27，： | 1 |
| 18 | Distinct stem cells contribute to mammary gland development and maintenance显示文摘 | Van Keymeulen A Rocha A S Ousset M et a1 | 2011 | Nature2011，479，7372： | 1 |
| 19 | Enantioselective ethylation of aldehydes with 1,3-N-donor ligands derived from (+)-camphoric acid显示文摘 | MURTINHO D ELISA S S M ROCHA G | | 0，，： | 1 |
| 20 | Acetate as a carbon source for hydrogen production by photosynthetie baeteria显示文摘 | Barbosa M J Rocha J M S Tramper J | 2001 | Journal of Biotechnology2001，85，1： | 1 |
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