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| 1 | 胆囊癌的临床诊疗现状与挑战显示文摘胆囊癌在胃肠道癌症中位居第五位,同时它也是胆道最常见的恶性肿瘤,约占80%~95%。这种肿瘤预后不佳,总体5年生存率低于5%,平均中位生存期〈6个月。因为胆囊癌在进展时可以没有任何症状,所以早期诊断是至关重要。术前诊断为胆囊结石,而术后确诊为胆囊癌的发生率为0.5%~1.5%。如果术前怀疑患者胆囊癌,则不应通过腹腔镜手术。流行病学研究已经确定了胆囊癌的发病率有地理和种族的显著差异:美洲的印第安人高发,东南亚地区也比较高,但在美洲和世界的其他地区发病率较低。环境诱发因素在胆囊癌的发展过程中发挥关键作用,胆石症、胆道和寄生虫感染的慢性炎症是最好的例证。在过去的10年里,改进成像技术和改良根治的手术方法可改善患者的预后,并帮助延长胆囊癌患者的存活时间。对于R0切除的胆囊癌患者,其总体5年生存率为21%~69%。在将来,潜在的诊断标志物的发展将对那些种族易感性或已知胆道解剖异常的人群提供早期筛查诊断的机会。 | Mislav Raki? Leonardo Patrlj Mario Kopljar Robert Kli?ek Marijan Kolovrat Bozo Loncar Zeljko Busic 冯铁诚 | 2016 | 中国普通外科杂志2016，25，2： | 24 |
| 2 | Impact of stress on solute transport in a fracture network: A comparison study显示文摘This paper compares numerical modeling of the effect of stress on solute transport (advection and matrix diffusion) in fractured rocks in which fracture apertures are correlated with fracture lengths. It is mainly motivated by the performance and safety assessments of underground radioactive waste repositories. Five research teams used different approaches to model stress/deformation, flow and transport processes, based on either discrete fracture network or equivalent continuum models. The simulation results derived by various teams generally demonstrated that rock stresses could significantly influence solute transport processes through stress-induced changes in fracture apertures and associated changes in permeability. Reasonably good agreement was achieved regarding advection and matrix diffusion given the same fracture network, while some observed discrepancies could be explained by different mechanical or transport modeling approaches. | Zhihong Zhao Jonny Rutqvist Colin Leung Milan Hokr Quansheng Liu Ivars Neretnieks Andrew Hoch Jirí Havlíek Yuan Wang Zhen Wang Yuexiu Wu Robert Zimmerman | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，2： | 6 |
| 3 | Plasma sterol evidence for decreased absorption and increased synthesis of cholesterol in insulin resistance and obesity 显示文摘 | Pathmaja P Robert HK Steven EK | 2011 | Am J Clin Nutr2011，94，4： | 1 |
| 4 | Advances in gastrointestinal intervention:The treatment of gastroduodenal and colorectal obstructions with metallic stents显示文摘 | MATTHEW AM ROBERT EK TODD HB | 2000 | Radiology2000，215，3： | 1 |
| 5 | Relationship between Leaf Area Index and Landsat TM spectral Vegetation Indices Across Three Temperate Zone Site显示文摘 | Turner DP Warren BC Robert EK etal | 1999 | Remote Sensing of Enviroment1999，70，1： | 1 |
| 6 | Accuracy of cervical pedicle screw placement using the funnel technique显示文摘 | Eldin EK Wicharn Y Robert W | 2001 | Spine2001，2622，： | 1 |
| 7 | Plasma sterol evidence for decreased absorption and increased synthesis of cholesterol in insulin resistance and obesity显示文摘 | Pathmaja P Robert HK Steven EK | | 0，，： | 1 |
| 8 | Lipomatous tumors of the liver: evaluation with CT and US 显示文摘 | Roberts JL Fishman EK Hartman DS | 1986 | Radiology1986，158，3： | 1 |
| 9 | Glucose Sensor O -GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock显示文摘 | Krista Kaasik Saul Kivim?e Jasmina J. Allen Robert J. Chalkley Yong Huang Kristin Baer Holger Kissel Alma L. Burlingame Kevan M. Shokat Louis J. Ptá?ek Ying-Hui Fu | 2013 | Cell Metabolism2013，，2： | 1 |
| 10 | Music hstening to facilitate relaxation and promote well- ness :integrated aspects of our neurophysiological responses to music显示文摘 | Robert EK | 2007 | Arts Psychother2007，34，11： | 1 |
| 11 | Experience and modification update for the minimally invasive Nuss technique for pectus excavatum repair in 303 patients显示文摘 | Daniel PC Robert EK Micheal J | 2002 | J Pediatr Surg2002，37，3： | 1 |
| 12 | Environmental and therapeutic issues in psychiatric hospital design: toward best practices显示文摘 | Bradley EK Robert AZ | 2006 | Psych Serv2006，57，10： | 1 |
| 13 | Advances in gastrointestinal in- tervention :The treatment of gastrointestinal and colorectal obstruc- tions with metallic stents显示文摘 | Matthew AM Robert EK Todd HB | 2000 | Radiol2000，215，： | 1 |
| 14 | Hygrothermal performance study of an innovative interior thermal insulation system显示文摘 | Zby(s)ek Pavlík Robert Cerny | 2009 | Applied Thermal Engineering2009，29，： | 1 |
| 15 | Preparation, characterization and antimicrobial efficiency of Ag/PDDA-diatomite nanocomposite显示文摘 | Ale? Paná?ek Anna Balzerová Robert Prucek Václav Ranc Renata Ve?e?ová Vendula Husi?ková Ji?í Pechou?ek Jan Filip Radek Zbo?il Libor Kvítek | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
| 16 | Experience and modification up-date for the minimally invasive Nuss technique for pectus excavatum repair in303patients显示文摘 | Daniel PC Robert EK Micheal J | 2002 | Peditr Surg2002，37，3： | 1 |
| 17 | Twenty-One Years of Experience With Minimally Invasive Repair of Pectus Excavatum by the Nuss Procedure in 1215 Patients显示文摘 | Robert EK Michael JG Robert O | 2010 | Annals of Surgery2010，252，6： | 1 |
| 18 | Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer 显示文摘 | Roberts CG Millar EK O'Toole SA | 2011 | Oncogene2011，30，28： | 1 |
| 19 | Costs of an emergency depart-ment-based accelerated diagnostic protocol vs hospitalization in patients with chest pain:a randomized controlled trial显示文摘 | Roberts RR Zalenski RJ Mensah EK | | 0，，20： | 1 |
| 20 | Correlaton between fibroin amino acid sequence and physical silk properties显示文摘 | Robert Fede(c) Michael Zǔrovec Franti(s)ek Sehnal | 2003 | The Journal of Biological Chemistry2003，278，35： | 1 |
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