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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Method for rapid on-site identification of VOCs显示文摘Rapid on-site identification of volatile organic compounds (VOCs) in ambient air is an important first step in remediation efforts. This study describes modification of a commercially available, portable GC/MS system and development of an analysis protocol for rapid (< 3 min) sampling and identification of VOCs typically found at contaminated sites at the low ppbv level. | Justin D Fair William F Bailey Robert A Felty Amy E Gifford Benjamin Shultes Leslie H Volles | 2009 | Journal of Environmental Sciences2009，21，7： | 8 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 5 | Glyphosate toxicity and the effects of long - term vegetation control on soil microbial communities 显示文摘 | Busse Matt D Ratcliff Alice W Shestak Carol J Powers Robert F | 2001 | Soil Biology and Biochemistry2001，33，： | 2 |
| 6 | The unique sensitivity of Walker rat tumour cells to difunctional agents is associated with a failure to recover from inhibition of DNA synthesis and increased chromosome damage 显示文摘 | Roberts J J Friedlos F Scott D | 1986 | Mutat Res1986，166，2： | 2 |
| 7 | Advances in the Treatment and Outcome of Brainstem Cavernous Malformation Surgery: A Single-Center Case Series of 300 Surgically Treated Patients显示文摘 | Adib A Abla Gregory P Lekovic Jay D Turner Jean G de Oliveira Randall Porter Robert F Spetzler | 2011 | Neurosurgery2011，，2： | 2 |
| 8 | Conflict and Power-Dependence Relations in Retailer-Supplier Channels 显示文摘 | James R Brown Robert F Lusch and Darrel D Muehling | 1983 | Journal of Retailing1983，59，4： | 1 |
| 9 | Application of Burkholderia cepacia and Trichoderma virens,alone and in combinations,a-gainst Meloidogyne incognita on bell pepper显示文摘 | MEYER S L F ROBERTS D P CHITWOOD D J | 2001 | Nematropica2001，，： | 1 |
| 10 | Influence of Adsorbed Gases on the Surface Energy of Graphite:Consequence on the Friction Behavior显示文摘 | Zaidi H Robert F Paulmier D | 1995 | Thin Solid Films1995，264，： | 1 |
| 11 | The solar system D/H ratio: Observations and theories 显示文摘 | Robert F Gautier D Dubrtdle B | 2000 | Space Sei Rev2000，92，： | 1 |
| 12 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 13 | Chemically grafted polymeric filters for chemical sensors: hyperbranched poly ( acrylic acid) films incorporatingh - cyclodextrin receptors and amine - functionalized filter layers 显示文摘 | Daniel L Dermody Robert F Peez D E | 1999 | Langmuir1999，15，3： | 1 |
| 14 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 15 | Ahered gene expression in liver from a murine moder of hyperhomocys- teinemia显示文摘 | ROBERT K CHASSE J F SANTIARD BARON D | 2003 | J Biol Chem2003，278，34： | 1 |
| 16 | Spatially Variant Contrast Enhancement Using Local Ranger Modification 显示文摘 | James D F Robert A S | 1983 | SPIE1983，2213，： | 1 |
| 17 | Generationof potentially bioactive ergosterol-derived products following pulsedultraviolet light exposure of mushrooms (Agaricus bisporus)显示文摘 | MICHAEL D K ROBERT B B MICHAEL F H | 2012 | FoodChemistry2012，135，2： | 1 |
| 18 | BioID:A Multimodal Biometric Identification System显示文摘 | Robert W F Ulrich D | 2000 | IEEE Computer2000，33，2： | 1 |
| 19 | NDE of damage in thick stiched composites using laser-based ultrasound with optical fibers for remote generation and detection显示文摘 | Robert F Anastasi Adam D Friedman Mark K Hinders | 1998 | Materials Evaluation1998，56，12： | 1 |
| 20 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
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