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| 1 | Assessment of lnc RNA GAS5, lnc RNA HEIH, lnc RNA BISPR and its m RNA BST2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4显示文摘BACKGROUND Hepatitis C virus(HCV)infection and its consequent complications are undeniably a public health burden worldwide,particularly in Egypt.Emerging evidence suggests that many lncRNAs have relevant roles in viral infections and antiviral responses.AIM To investigate the expression profiles of circulating lncRNAGAS5,lncRNAHEIH,lncRNABISPR and mRNABST2 in naïve,treated and relapsed HCV Egyptian patients,to elucidate relation to HCV infection and their efficacy as innovative biomarkers for the diagnosis and prognosis of HCV GT4.METHODS One hundred and thirty HCV-infected Egyptian patients and 20 healthy controls were included in this study.Serum lncRNAs and mRNABST2 were measured using quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Our results indicated that serum lncRNAGAS5 and LncRNABISPR were upregulated,whereas mRNA BST2 and LncRNA HEIH were downregulated in naïve patients.In contrast,HCV patients treated with sofosbuvir and simeprevir;with sofosbuvir and daclatasvir;or with sofosbuvir,daclatasvir and ribavirin exhibited lower levels of lncRNAGAS5 and lncRNABISPR with higher mRNABST2 compared to naïve patients.Notably,patients relapsed from sofosbuvir and simeprevir showed higher levels of these lncRNAs with lower mRNABST2 compared to treated patients.LncRNAGAS5 and lncRNABISPR were positively correlated with viral load and ALT at P<0.001,whereas mRNABST2 was negatively correlated with viral load at P<0.001 and ALT at P<0.05.Interestingly,a significant positive correlation between lncRNA HEIH and AFP was observed at P<0.001.CONCLUSION Differential expression of these RNAs suggests their involvement in HCV pathogenesis or antiviral response and highlights their promising roles in diagnosis and prognosis of HCV. | Nourhan M El Samaloty Marwa I Shabayek Ramy S Ghait Shohda A El-Maraghy Sherine M Rizk Maha M El-Sawalhi | 2020 | World Journal of Gastroenterology2020，26，2： | 2 |
| 2 | Critical switching impulse breakdown of long bundle-coductor gaps显示文摘 | Farouk A M Rizk | 1996 | IEEE Transactions on Power Delivery1996，11，1： | 1 |
| 3 | Critical switching impulse breakdown of long bundle-coductor gaps显示文摘 | Farouk A M Rizk | 1996 | IEEE Transactions on Power Delivery1996，11，1： | 1 |
| 4 | Influence of atonik and atonik-G treatments on Growth and volatile oil content of matricaria chamomilla 显示文摘 | Al-Badaway A A Abdalla N M Rizk G A | 1984 | Proc Plant growth Regul Soc Am1984，，11： | 1 |
| 5 | Modeling of transmission line exposure to direct lightning strokes显示文摘 | Rizk F A M | 1990 | IEEE Trans on Power Delivery1990，5，4： | 1 |
| 6 | Spnntaneous intracranial hypotension syndrome treated with fludrocorlisones显示文摘 | Rizk M E Khatib M Yamout B el al | 2015 | A Case Rep2015，4，1： | 1 |
| 7 | Influence of atonik and atonik-G treatments on growth and volatile oil content of matricaria chamomilla显示文摘 | AL-Badaway A A Abdalla N M Rizk G A | 1984 | Proc Plantgrowth Regul Soc Am1984，，11： | 1 |
| 8 | Analysis of space charge generating devices for lightning protection: Performance in slow varying fields显示文摘 | Rizk F A M | 2010 | IEEE Transactions on Power Delivery2010，25，3： | 1 |
| 9 | Exposure of overhead conductors to direct lightning strikes: Modeling of positive streamer inhibition 显示文摘 | Rizk F A M | 2011 | IEEE Transactions on Power Delivery2011，26，2： | 1 |
| 10 | Flouorimetric determination of aminoglycoside antibiotics using lanthanide probe iron spectroscopy显示文摘 | Rizk M EL-Shabrawy Y Zakhari N A | 1995 | Talanta1995，42，12： | 1 |
| 11 | On-line nuclear ash gauge for coal based on gamma-ray transmission techniques显示文摘 | Rizk R A M EI-kateb A H Abdul-kader A M | 1999 | Journal of Radioanalytical and Nuclear Chemistry1999，242，1： | 1 |
| 12 | Differential pulse polarographic determination of ofloxacin in pharmaceuticals and biological fluids显示文摘 | RIZK M BEALA F ALY F A | 1998 | Talanta1998，46，： | 1 |
| 13 | Switching impulse strength of air insulation: leader in- ception criterion显示文摘 | Rizk F A M | 1989 | IEEE Transactions on Power Delivery1989，4，4： | 1 |
| 14 | Mathematical models for pollution flashover显示文摘 | RIZK F A M | 1981 | Electra1981，，78： | 1 |
| 15 | Matemai risk factors for abnor- ms] vascular coiling of the umbilical cord 显示文摘 | Ezimokhai M Rizk DE Thomas L | 2000 | Am J Pe rinatol2000，17，： | 1 |
| 16 | Critical switching impulse strength of phase-to-phase air insulation显示文摘 | Rizk F A M | 1993 | IEEE Transactions on Power Delivery1993，8，3： | 1 |
| 17 | Modeling of trigger-wire corona effects in rocket-triggered lightning显示文摘 | Rizk F A M | 2011 | IEEE Transactions on Power Delivery2011，26，2： | 1 |
| 18 | Modeling of Transmission Line Exposure to Direct Lightning Strokes 显示文摘 | RIZK F A M | 1990 | IEEE Transactions on Pow- er Delivery1990，5，4： | 1 |
| 19 | Abnormal vasgular coiling of the umbilical cord in gestational diabetes mellitus显示文摘 | Ezimokhai M Rizk DE Thomas L | 2001 | Arch Physiol Bio- chem2001，109，： | 1 |
| 20 | Critical switching impulse breakdown of long bun- die-conductor gaps显示文摘 | Rizk F A M | 1996 | IEEE Transactions on Power Delivery1996，11，1： | 1 |
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