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| 1 | Prognostic value of endothelial dysfunction in type 1 diabetes mellitus显示文摘Patients with diabetes mellitus are at high risk of developing atherosclerosis, associated with higher rates of micro and macro vascular involvement such as coronary artery disease and renal disease. The role of hyperglycemia to induce synthesis of reactive oxygen species by the oxidation of glucose, leading to an increased production of advanced glycosylation end products, as well as inflammation and oxidative stress has been proposed as a possible mechanism in the pathogenesis of endothelial dysfunction(ED). The interaction between C-peptide- the connecting segment of pro-insulin-and nitric oxide in vasodilation is also discussed. Therefore, endothelial dysfunction has been identified as an early marker of vascular disorder in type 1 and type 2 diabetes mellitus. In some other diseases, ED has been considered an independent predictor of vascular disease, regardless of the method used. Studies have demonstrated the importance of endothelial dysfunction as an useful tool for identifying the risk of vascular complications in patients with type 1 diabetes mellitus, particularly as regards to renal impairment. The aim of this review is to clarify the prognostic value of endothelial dysfunction as a marker of vascular disease in these subjects. | Ana Marice Ladeia Raphael Ribeiro Sampaio Maiara CostaHita Luis F Adan | 2014 | World Journal of Diabetes2014，5，5： | 2 |
| 2 | Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population显示文摘Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field. | Frances M Mitchell Sanjay K Prasad Gerald F Greil Peter Drivas Vassilios S Vassiliou Claire E Raphael | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 2 |
| 3 | Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals显示文摘 | BENOIT F RAPHAEL M S JEANNE G | 2006 | Ecotoxicology and Environmental Safety2006，63，2： | 1 |
| 4 | Effects that bovine sperm cryopreservation using two different extenders has on sperm membranes and chromatin显示文摘 | Celeghini E C de Arruda R P de Andrade A F Nascimento J Raphael C F Rodrigues P H | | 0，，： | 1 |
| 5 | Prediction of cadmium and zinc concentration in wheat grain from soils affected by the application of phosphate fertilizers varying in Cd concentration显示文摘 | Matthieu F Cynthia Grant Raphael Lamber Sebastien Sauve | 2009 | Nutrient Cycling in Agroecosystems2009，83，2： | 1 |
| 6 | Data mining techniques for improving the reliability of system identification 显示文摘 | SAiTTA S RAPHAEL B SMITH F C | 2005 | Advanced Engineering Informatics2005，19，4： | 1 |
| 7 | The response of burn scars to intralesionsal verapamil 显示文摘 | Raphael C L Howard D Aileen F | 1994 | Arch Surg1994，129，： | 1 |
| 8 | Data Mining Techniques for Improving the Reliability of System Identification 显示文摘 | SAITTA S RAPHAEL B SMITH F C | 2005 | Advanced Engineering Informatics Computing in Civil Engineering2005，19，4： | 1 |
| 9 | PPAR γ controls cell proliferation and apoptosis in an R132 dependent manner显示文摘 | Lluls F Vivane E Raphael R | 2003 | Oncogene2003，22，： | 1 |
| 10 | Effect of annual intramuscular vitamin D on fracture risk in elderly men and women-a population- based, randomized, double-blind, placebo-controlled trial 显示文摘 | Smith H Anderson F Raphael H | 2007 | Rheuma- tology(Oxford)2007，46，12： | 1 |
| 11 | Profiles and quantiza?tion of the blow up mass for critical nonlinear Schrodinger equation显示文摘 | MERLE F RAPHAEL P | 2005 | Comm Math Phys2005，253，3： | 1 |
| 12 | Blow up dynamics and upper bound on the blow up rate for critical non?linear Schrodinger equation显示文摘 | MERLE F RAPHAEL P | 2005 | Ann of Math2005，161，1： | 1 |
| 13 | On a sharp lower bound on the blow up rate for the L2 critical nonlinear Schrodinger equation显示文摘 | MERLE F RAPHAEL P | 2006 | J Amer Math Soc2006，19，1： | 1 |
| 14 | Fludarabine in paedi- atric steroid - refractory inflammatory lung injury after stem cell transplantation显示文摘 | Raphael M F Rottier BL Boelens J J | 2013 | Eur Respir J2013，41，2： | 1 |
| 15 | Cancer vaccine 显示文摘 | Raphael F Charlotte H Malcolm K | 2001 | Hemalology/Oncology Clinics d North America2001，15，4： | 1 |
| 16 | Monoclonal antibody induced heating loss显示文摘 | NAIR T S RAPHAEL Y DOLAN D F | 1995 | Hear Res1995，83，12： | 1 |
| 17 | Reasoning about conditional con-straint specification problems and feature models显示文摘 | RAPHAEL F BARRY O | 2011 | Artifi-cial Intelligence for Engineering Design Analysis and Manu-facturing2011，25，2： | 1 |
| 18 | A Directed Pro-tein Interaction Network for Investigating Intracellular Signal Trans-duction显示文摘 | ARUNACHALAM V ULRICH S RAPHAELE F | 2011 | Science Signaling2011，4，189： | 1 |
| 19 | System identification through model composition and stochastic search显示文摘 | Robert-Nicoud Y Raphael B Smith I F C | 2005 | ASCE Journal of Computing in Civil Engineering2005，19，3： | 1 |
| 20 | Data mining techniques for improving the reliability of system identification 显示文摘 | Saitta S Raphael B Smith I F C | 2005 | Advanced Engineering Informatics2005，，19： | 1 |
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