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| 1 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 2 | 囊性纤维化:太多NaCl,太少HCO_3^-(英文)显示文摘胰腺囊性纤维化(cystic fibrosis,CF)是一种单基因缺陷导致的致死性遗传疾病,在高加索人种中广泛分布。这种疾病在其它人种的发生率非常低,但据报道大部分人种中发现有该基因的突变。本文对CF发生的分子和病理生理学基本概念进行阐述。首先,阐述了CF的病理学和遗传特征,其基因产物囊性纤维化跨膜电导调节体(cystic fibrosis transmembrane con- ductance regulator,CFTR)的分子结构、特征、功能和调控。其次,由于突变的主要表现是电解质转运失调,其病理学效应和机制在两个典型受累器官中得到了很好的阐明,一个是汗腺,其病理发生是由于分泌过多NaCl,另一个是胰腺,其病理发生是由于分泌太少HCO_3^-。然而,CF的发病率和死亡率主要来自难治性呼吸道感染,其发生机制存存争议,我们推断可能的机制为阴离子转运失调导致CF肺部慢性感染。 | QUINTON Paul M | 2007 | 生理学报2007，59，4： | 5 |
| 3 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 4 | Src family kinase- mediated and Erk - mediated thromboxane A2 generation are essential for VWF/GP Ⅰ b - induced fibrinogen receptor activation in human platelets显示文摘 | GARCIA A QUINTON T M DORSAM R T | 2005 | Blood2005，6，： | 1 |
| 5 | Assessment of erosion hazard with the USLE and GIS:a case study of the upper Ewaso Ng'iro North Basin of Kenya显示文摘 | Mati B M Morgan R P C Gichuki F N Quinton J N Brewer T R Liniger H P | | 0，，02： | 1 |
| 6 | The effect of cold and dietary energy on right ventricle hypertrophy, right ventricle failure and ascites in meat-type chickens 显示文摘 | Julian R J McMillan I Quinton M | 1989 | Avian Pathology1989，18，： | 1 |
| 7 | Leptin and leptin-binding activity in women with recurrent miscarriage:correlation with pregnancy outcome显示文摘 | LAIRD S M QUINTON N D ANSTIE B | 2001 | Hum Reprod2001，16，9： | 1 |
| 8 | GnRH neuronal development: insights into hypogonadotrophic hypogon- adism 显示文摘 | MacColl G Quinton R Bouloux P M | 2002 | Trends in Endocrinology and Metabolism: TEM2002，13，3： | 1 |
| 9 | Comparison of selection methods at the same level of inbreeding 显示文摘 | Quinton M Smith C Goddard M E | 1992 | J Anim Sci1992，70，： | 1 |
| 10 | Comparison of evaluation-selection systems for maximizing genetic response at the same level of inbreeding 显示文摘 | Quinton M Smith C | 1995 | J Anim Sci1995，73，： | 1 |
| 11 | A novelbreast/ovarian cancer peptide vaccine platform that promotesspecific type-1 but not Treg/Trl-type responses显示文摘 | Karkada M Weir GM Quinton T | 2010 | JImmunother2010，33，3： | 1 |
| 12 | Evaluation of field wetlands for mitigation of diffuse pollution from agriculture: sediment retention, cost and effectiveness 显示文摘 | Ockenden M C Deasy C Quinton J N | 2012 | Environmental Science & Policy2012，24，： | 1 |
| 13 | Grassed buffer strips for the control of nitrate leaching to surface waters in headwater catchments 显示文摘 | Leeds - Harrison P Quinton JN Walker M | 1999 | Ecological Engineering1999，12，3： | 1 |
| 14 | Subsurface drainage from hummock-covered hillslopes in the Arctic tundra显示文摘 | Quinton W L Gray D M Marsh P | 2000 | Journal of Hydrology2000，237，12： | 1 |
| 15 | The selective removal of phosphorus from soil : is event size important? 显示文摘 | Quinton J N Catt J A Hess T M | 2001 | Journal of Environmental Quality2001，30，2： | 1 |
| 16 | Methamphetaminein- dueed inhibition of mitochondrial complex II: roles of glutamate and peroxynitrite显示文摘 | Brown J M Quinton M S Yamamoto B K | 2005 | Journal of Neurochemistry2005，95，2： | 1 |
| 17 | The effect of cold and dietary energy on right ventrricular hypertrophy,right ventricular failure and ascites in meat-type chickens显示文摘 | Julian R J Mcmillan I Quinton M | 1989 | Avian Pathol1989，18，： | 1 |
| 18 | The effect of cold and dietary energy on right ventricle hypertrophy, right ventricle failure and ascites in meat-type chickens显示文摘 | JULIAN R J MCMILLAN I QUINTON M | 1989 | Avian Pathol1989，18，4： | 1 |
| 19 | The selective removal of phosphorus from soil:is event size important?显示文摘 | Quinton J N Catt J A Hess T M | 2001 | J Environ Qual2001，30，： | 1 |
| 20 | Meta-analysis of genetic parameter estimates for reproduction,growth and carcass traits of pigs in the tropics显示文摘 | AKANNO E SCHENKEL F S QUINTON M | 2013 | Livest Sci2013，152，23： | 1 |
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