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您的检索式：作者名="Quentin Montardy"
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| 1 | 脑干蓝斑到前庭神经核的神经环路投射及在压力应激下的激活研究显示文摘前庭神经核(Vestibular Nuclei)是保持平衡的关键核团,其功能异常与晕动病、前庭偏头痛、帕金森氏病等多种疾病状态密切关联,压力应激往往加重以上疾病的症状并伴随着蓝斑(Locus Coeruleus)去甲肾上腺素能系统的激活。该研究利用转基因小鼠结合病毒示踪显示从蓝斑到前庭神经核的神经投射,并利用酪氨酸羟化酶(Tyrosine Hydroxylase)抗体免疫荧光染色确定蓝斑-前庭神经核的投射为去甲肾上腺素能。结果显示,小鼠在睡眠剥夺压力刺激下蓝斑去甲肾上腺素能神经元被强烈激活,而前庭神经核神经元激活不明显,提示睡眠剥夺可能通过蓝斑-前庭神经核的去甲肾上腺素能神经调制起作用。该结果可为继续探究蓝斑-前庭神经核神经环路在压力应激与前庭神经核功能调控之间的重要作用提供解剖结构学基础。 | 魏梦霞 纪树钦 李子杰 林子逸 MONTARDY Quentin 王立平 李蕾 | 2021 | 集成技术2021，10，5： | 1 |
| 2 | Activation of parvalbumin interneurons in anterior cingulate cortex impairs observational fear显示文摘The ability to detect conspecific's distress is crucial for animal survival.In rodent models,observational fear(OF) occurs when one animal perceives another fear related negative emotions,which may model certain behaviors caused by witnessing traumatic experiences in humans.Anterior cingulate cortex(ACC) has been showed to play a crucial role in OF.However,cellular and neural circuit basis relating to ACC governing OF is poorly understood.Here,we used Designer Receptor Exclusively Activated by a Designer Drug(DREADD) system to investigate the cell type specific circuit mechanism of ACC in OF.Firstly,inhibitory hM4D(Gi) designer receptor together with clozapine N-oxide(CNO) injection was applied to inactivate ACC neurons in the observer mice.We found that,chemogenetic inhibition of ACC resulted in a decreased freezing response in the observer mice.Next,combining PV-ires-Cre mice and Cre-dependent DREADD system,we selectively targeted the ACC parvalbumin(PV) interneurons with the excitatory hM3D(Gq) designer receptor.Activation of ACC PV interneurons following CNO injection reduced freezing response in the observer mice,while had no effect on freezing response in the demonstrator mice.Finally,monosynaptic rabies retrograde tracing revealed that ACC PV interneurons receive inputs from the mediodorsal thalamic nucleus(MD) and the ventromedial thalamic nucleus(VM),both known for their roles in OF.Taken together,these findings reveal that ACC activation is important for OF,during which PV interneurons in ACC play an important regulatory role.Abnormal function of ACC PV interneurons might contribute to the pathology of empathy-deficits related diseases,such as autism and schizophrenia. | Chunran Zhou Zheng Zhou Yushui Han Zhuogui Lei Lei Li Quentin Montardy Xuemei Liu Fuqiang Xu Liping Wang | 2018 | Science Bulletin2018，63，12： | 1 |
| 3 | Characterization of glutamatergic VTA neural population responses to aversive and rewarding conditioning in freely-moving mice显示文摘The Ventral Tegmental Area(VTA) is a midbrain structure known to integrate aversive and rewarding stimuli, but little is known about the role of VTA glutamatergic(VGluT2) neurons in these functions.Direct activation of VGluT2 soma evokes rewarding behaviors, while activation of their downstream projections evokes aversive behaviors. To facilitate our understanding of these conflicting properties, we recorded calcium signals from VTAVGluT2+ neurons using fiber photometry in VGluT2-cre mice to investigate how this population was recruited by aversive and rewarding stimulation, both during unconditioned and conditioned protocols. Our results revealed that, as a population, VTAVGluT2+neurons responded similarly to unconditioned-aversive and unconditioned-rewarding stimulation. During aversive and rewarding conditioning, the CS-evoked responses gradually increased across trials whilst the US-evoked response remained stable. Retrieval 24 h after conditioning, during which mice received only CS presentation, resulted in VTAVGluT2+ neurons strongly responding to CS presentation and to the expected-US but only for aversive conditioning. To help understand these differences based on VTAVGluT2+ neuronal networks, the inputs and outputs of VTAVGluT2+ neurons were investigated using Cholera Toxin B(CTB) and rabies virus. Based on our results, we propose that the divergent VTAVGluT2+ neuronal responses to aversion and reward conditioning may be partly due to the existence of VTAVGluT2+ subpopulations that are characterized by their connectivity. | Quentin Montardy Zheng Zhou Zhuogui Lei Xuemei Liu Pengyu Zeng Chen Chen Yuanming Liu Paula Sanz-Leon Kang Huang Liping Wang | 2019 | Science Bulletin2019，64，16： | 0 |
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