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| 1 | Prediction of recent bank retreat processes at typical sections in the Jingjiang Reach显示文摘The Jingjiang Reach is experiencing continuous channel degradation owing to operation of the Three Gorges Project(TGP)in2003.Significant retreat processes at composite riverbanks have occurred at local sites of this reach,which may influence the stability of the river regime and the effect of existing river training works.Therefore,bank retreat plays a key role in fluvial processes of the Jingjiang Reach,and it is necessary to predict the long-term processes of bank retreat at typical sections in the reach.In this study,various factors influencing bank retreat in the Jingjiang Reach are investigated,based on bank erosion processes at four sections and the corresponding flow and sediment conditions.It is discovered that fluvial erosion intensity is a dominant factor in controlling the processes of bank retreat in the reach,although other factors,such as bank soil properties,can also influence bank retreat.The bankfull width at a section with severe bank erosion since 2002 is defined as being equal to the sum of the bankfull width in 2002 and the accumulated bank retreat distance after 2002.The magnitude of the bankfull width can be expressed as an exponential function of the previous 5-year average fluvial erosion intensity during flood seasons.The accumulated distances of bank retreat at four sections over the period 2002–2012 are predicted using the proposed empirical relationships,with the calculated bank retreat processes agreeing well with observed data. | XIA JunQiang ZONG QuanLi ZHANG Yi XU QuanXi LI XiaoJuan | 2014 | Science China(Technological Sciences)2014，57，8： | 20 |
| 2 | Randomized,multicenter,open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer:NCT01631357显示文摘Dear Editor,Cytokine-induced killer(CIK)cells have been recognized as a new type of anti-tumor effector cells.CIK cells are a mixture of T lymphocytes.Among them,CD3+/CD56+T cells,which are rare in uncultured peripheral blood,are the main effector cells.CIK cells can proliferate rapidly in vitro,with stronger antitumor activity,broader target tumor spectrum,and lower adverse effect than other reported antitumor effector cells.1 Their ease of production in vitro and antitumor potential have made them suitable candidates for cell therapy regimens in solid and hematopoietic tumor treatments.1,2 Our previous retrospective study showed that the median progression-free survival(PFS)and overall survival(OS)in untreated,advanced non-small-cell lung cancer(NSCLC)patients who received CIK cell immunotherapy plus chemotherapy(13 and 24 months,respectively)were significantly longer than in those who received chemotherapy alone(6 and 10 months,respectively).2 But so far,there is no prospective,multicenter clinical study in lung cancer.Based on our previous study,we designed this randomized,multicenter,open-label trial to further evaluate the clinical efficacy of CIK cell immunotherapy plus chemotherapy in patients with advanced squamous NSCLC(ClinicalTrials.gov number,NCT01631357). | Liang Liu Quanli Gao Jingting Jiang Junping Zhang Xin Song Jiuwei Cui Yunbin Ye Zhiyu Wang Xinwei Zhang Xiubao Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 3 | Synthesis of sulfur doped C_(3)N_(4) with enhanced photocatalytic activity in molten salt显示文摘In this paper,sulfur doped g-C_(3)N_(4)(S-g-C_(3)N_(4))was successfully prepared at 500℃ for 3 h via a modified molten salt method using dicyandiamide as the main raw material,trithiocyanuric acid as the sulfur source and LiBreKCl as the reaction medium.The as-prepared SeCN5.0% sample(the mass ratio of trithiocyanuric acid to dicyandiamide was 5.0%)composed of irregular flakes showed a band gap of 1.83 eV,which was narrower than that(2.55 eV)of pristine g-C_(3)N_(4).The SeCN5.0% sample also exhibited an outstanding absorption capacity of visible light.Moreover,the photodegradation rate toward methylene blue and tetracycline were respectively 10 and 20 times as high as that of bulk g-C_(3)N_(4) prepared by conventional heating methods,confirming its superior photocatalytic performance.These results can be attributed to that the replacement of lattice nitrogen with sulfur atom tuned the electronic structure of g-C_(3)N_(4),improved the absorption of visible light,optimized the separation of photogenerated electron-hole pairs,and consequently enhanced the photocatalytic activity of g-C_(3)N_(4).Moreover,the trapping experiments implied that hole(ht)and superoxide radical($O2)were the main active species in the process of photodegradation. | Keke Guan Junyi Li Wen Lei Honghong Wang Zhaoming Tong Quanli Jia Haijun Zhang Shaowei Zhang | 2021 | Journal of Materiomics2021，7，5： | 2 |
| 4 | Meiotic nuclear divisions 1(MND1)fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma显示文摘Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients. | Quanli Zhang Run Shi Yongkang Bai Lijuan Meng Jingwen Hu Hongyu Zhu Tongyan Liu Xiaomeng De Siwei Wang Jie Wang Lin Xu Guoren Zhou Rong Yin | 2021 | Cancer Communications2021，41，6： | 2 |
| 5 | Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies显示文摘Objective:Chimeric antigen receptor-modified T(CAR-T)cells have shown impressive results against relapsed/refractory B cell malignancies.However,the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of peripheral blood T cells,thus making some patients ineligible for the procedure.Methods:We developed a simple method for CAR-T cell preparation requiring small volumes of peripheral blood.First,CD3+T cells isolated from 50 mL peripheral blood from patients(B-cell malignancies)were stimulated with immobilized anti-CD3/RetroNectin in 6-well plates and then transduced with CAR-expressing lentiviral vector.After 4 d,the T cells were transferred to culture bags for large-scale CAR-T cell expansion.In vitro and animal experiments were performed to evaluate the activity of the manufactured CAR-T cells.Finally,29 patients with B-cell acute lymphoblastic leukemia(B-ALL)and 9 patients with B-cell lymphoma were treated with the CAR-T cells.Results:The CAR-T cells were expanded to 1–3×10^(8) cells in 8–10 d and successfully killed B cell-derived malignant tumor cells in vitro and in vivo.For patients with B-ALL,the complete remission rate was 93%1 month after CAR-T cell infusion;after 12 months,the overall survival(OS)and leukemia-free survival rates were 69%and 31%,respectively.For patients with lymphoma,the objective response rate(including complete and partial remission)was 78%2 months after CAR-T cell infusion,and after 12 months,the OS and progression-free survival rates were 71%and 43%,respectively.Cytokine-release syndrome(CRS)occurred in 65.51%and 55.56%of patients with B-ALL and B-cell lymphoma,respectively;severe CRS developed in 20.69%of patients with B-ALL and in no patients with lymphoma.Conclusions:Our novel method can generate sufficient numbers of CAR-T cells for clinical use from 50–100 mL peripheral blood,thus providing an alternative means of CAR-T cell generation for patients ineligible for leukapheresis. | Lu Han Jian Zhou Linlin Li Keshu Zhou Lingdi Zhao Xinghu Zhu Qingsong Yin Yufu Li Hongqin You Jishuai Zhang Yongping Song Quanli Gao | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 6 | Angular distribution of terahertz emission from laser interactions with solid targets显示文摘Intense femtosecond laser-plasma interactions can produce high power terahertz radiations.In our experiment,the polished copper target was irradiated by a p-polarized laser with intensity of more than 1018 W/cm2 at an incident angle of 67.5 from the target normal.The THz energy from three dierent detection angles is measured.The maximum emission is found in the direction at an angle of 45 to the laser backward direction,which is more than one order of magnitude higher than in the other two directions.A simple theoretical model has been established to explain the measurements. | DU Fei LI Chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi GE XuLei LI YuTong MA JingLong LIU XiaoLong ZHANG Lu SHENG ZhengMing CHEN LiMing LU Xin DONG QuanLi WANG ZhaoHua WEI ZhiYi ZHANG Jie | 2012 | Science China(Information Sciences)2012，55，1： | 2 |
| 7 | Three-dimensional graphitic carbon sphere foams as sorbents for cleaning oil spills显示文摘Frequent offshore oil spill accidents, industrial oily sewage, and the indiscriminate disposal of urban oily sewage have caused seri- ous impacts on the human living environment and health. The traditional oil-water separation methods not only cause easily environmental secondary pollution but also a waste of limited resources. Therefore, in this work, three-dimensional (3D) graphitic carbon sphere (GCS) foams (collectively referred hereafter as 3D foams) with a 3D porous structure, pore size distribution of 25-200 μm, and high porosity of 62vol% were prepared for oil adsorption via gel casting using GCS as the starting materials. The results indicate that the water contact angle (WCA) of the as-prepared 3D foams is 130°. The contents of GCS greatly influenced the hydrophobicity, WCA, and microstructure of the as-prepared samples. The adsorption capacities of the as-prepared 3D foams for paraffin oil, vegetable oil, and vacuum pump oil were approximately 12-15 g/g, which were 10 times that of GCS powder. The as-prepared foams are desirable characteristics of a good sorbent and could be widely used in oil spill accidents. | Saisai Li Haijun Zhang Longhao Dong Haipeng Liu Quanli Jia | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，3： | 1 |
| 8 | Fabrication and micro-microwave properties of Ni hollow powders by electroless platingand template removing method显示文摘 | Zhang Haijun Liu Yun Jia Quanli | 2007 | Powder Technology2007，，： | 1 |
| 9 | Preparation of titanium nitride ultrafine powders by sol-gel and microwave carbothermal reduction nitridation methods显示文摘 | Zhang Haijun Li Faliang Jia Quanli | 2009 | Ceramics International2009，35，： | 1 |
| 10 | Preparation and microwave properties of Ni-SiC ultrafine powder by electroless plating显示文摘 | Zhang Haijun Wu Xiangwei Jia Quanli | 2007 | Materials and Design2007，28，： | 1 |
| 11 | Progress and Developing Trend of Purging Plugs for Refining Ladle显示文摘Damage reasons of purging plugs for refining ladle and research progress on thermal shock resistance of corundum- spinel purging plugs were summarized. Research achievements and application results of nonoxides bonded corundum purging plugs for refining ladle were briefly reviewed. The further research and developing trend of purging plugs was proposed. | ZHANG Ju SUN Xiaogai JIA Quanli WU Ran | 2014 | China's Refractories2014，23，2： | 1 |
| 12 | Modelling loop-top X-ray source and reconnection outflows in solar flares with intense lasers显示文摘 | Zhong Jiayong Li Yutong Wang Xiaogang Wang Jiaqi Dong Quanli Xiao Chijie Wang Shoujun Liu Xun Zhang Lei An Lin Wang Feilu Zhu Jianqiang Gu Yuan He Xiantu Zhao Gang Zhang Jie | 2010 | Nature Physics2010，，12： | 1 |
| 13 | Fabrication and mi- croulave properties of Ni hollow powders by eleetroless plat- ing and template removing method 显示文摘 | Zhang Haijun Liu Yun Jia Quanli | 2007 | Powder Technology2007，，178： | 1 |
| 14 | Association of Myeloid-derived Suppressor Cells and Efficacy of Cytokine-induced Killer Cell Immunotherapy in Metastatic Renal Cell Carcinoma Patients显示文摘 | Zibing Wang Yong Zhang Yuqing Liu Li Wang Lingdi Zhao Tiejun Yang Chaohong He Yongping Song Quanli Gao | 2014 | Journal of Immunotherapy2014，，： | 1 |
| 15 | Computing a ground appropriateness index for route selection in permafrost regions显示文摘The reasonable calculation of ground appropriateness index in permafrost region is the precondition of highway route design in permafrost region. The theory of knowledge base and fuzzy mathematics are applied, and the damage effect of permafrost is considered in the paper. Based on the idea of protecting permafrost the calculation method of ground appropriateness index is put forward. Firstly, based on the actual environment conditions, the paper determines the factors affecting the road layout in permafrost areas by qualitative and quantitative analysis, including the annual slope, the average annual ground temperature of permafrost, the amount of ice in frozen soil, and the interference engineering. Secondly,based on the knowledge base theory and the use of Delphi method, the paper establishes the knowledge base, the rule base of the permafrost region and inference mechanism. The method of selecting the road in permafrost region is completed and realized by using the software platform. Thirdly, taking the Tuotuo River to Kaixin Mountain section of permafrost region as an example, the application of the method is studied by using an ArcGIS platform.Results show that the route plan determined by the method of selecting the road in permafrost region can avoid the high temperature and high ice content area, conform the terrain changes and evade the heat disturbance among the existing projects. A reasonable route plan can be achieved, and it can provide the basis for the next engineering construction. | Chi Zhang Quanli Gong Yuanyuan Liu Jiao Yan Min Zhang | 2017 | Journal of Traffic and Transportation Engineering(English Edition)2017，4，5： | 1 |
| 16 | Fabrication and microwave properties of Ni hollow powders by electroless plating and template removing method显示文摘 | Zhang Haijun Liu Yun Jia Quanli | 2007 | Powder Technol2007，178，： | 1 |
| 17 | Modelling loop-top X-ray source and reconnection outflows in solar flares with intense lasers显示文摘 | Zhong Jiayong Li Yutong Wang Xiaogang Wang Jiaqi Dong Quanli Xiao Chijie Wang Shoujun Liu Xun Zhang Lei An Lin Wang Feilu Zhu Jianqiang Gu Yuan He Xiantu Zhao Gang Zhang Jie | 2010 | Nature Physics2010，，12： | 1 |
| 18 | 显示文摘 | Zhang Haijun Liu Yun Jia Quanli | 2007 | Powder Technology2007，178，： | 1 |
| 19 | A heterotrophic nitrification-aerobic denitrification bacterium Halomonas venusta TJPU05 suitable for nitrogen removal from high-salinity wastewater显示文摘A novel salt-tolerant heterotrophic nitrification and aerobic denitrification(HN-AD)bacterium was isolated and identified as Halomonas venusta TJPU05(H.venusta TJPU05).The nitrogen removal performance of H.venusta TJPU05 in simulated water(SW)with sole or mixed nitrogen sources and in actual wastewater(AW)with high concentration of salt and nitrogen was investigated.The results showed that 86.12%of NH_(4)^(+)-N,95.68%of NO_(3)^(-)-N,100%of NO_(2)^(-)-N and 84.57%of total nitrogen(TN)could be removed from SW with sole nitrogen sources within 24 h at the utmost.H.venusta TJPU05 could maximally remove 84.06%of NH_(4)^(+)-N,92.33%of NO_(3)^(-)-N,92.9%of NO_(2)^(-)-N and 77.73%of TN from SW with mixed nitrogen source when the salinity was above 8%.The application of H.venusta TJPU05 in treating AW with high salt and high ammonia nitrogen led to removal efficiencies of 50.96%,47.28%and 43.19%for NH_(4)^(+)-N,NO_(3)^(-)-N and TN respectively without any optimization.Furthermore,the activities of nitrogen removal–related enzymes of the strain were also investigated.The successful detection of high level activities of ammonia oxygenase(AMO),hydroxylamine oxidase(HAO),nitrate reductase(NAR)and nitrite reductase(NIR)enzymes under high salinity condition further proved the HN-AD and salt-tolerance capacity of H.venusta TJPU05.These results demonstrated that the H.venusta TJPU05 has great potential in treating high-salinity nitrogenous wastewater. | Quanli Man Peilian Zhang Weiqi Huang Qing Zhu Xiaoling He Dongsheng Wei | 2022 | Frontiers of Environmental Science & Engineering2022，16，6： | 1 |
| 20 | The effect of secondary metal on Mo2C/Al2O3 catalyst for the partial oxidation of methane to syngas显示文摘 | Quanli Zhu Bin Zhang Jun Zhao | 2004 | J Mol Catal A:Chem2004，213，： | 1 |
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