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| 1 | Mesenchymal stromal cells-exosomes:a promising cell-free therapeutic tool for wound healing and cutaneous regeneration显示文摘Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types,growth factors,extracellular matrix(ECM),nerves,and blood vessels.Mesenchymal stromal cells(MSCs)take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans.Exosomes,which are among the key products MSCs release,mimic the effects of parental MSCs.They can shuttle various effector proteins,messenger RNA(mRNA)and microRNAs(miRNAs)to modulate the activity of recipient cells,playing important roles in wound healing.Moreover,using exosomes avoids many risks associated with cell transplantation.Therefore,as a novel type of cell-free therapy,MSC-exosome-mediated administration may be safer and more efficient than whole cell.In this review,we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration.In addition,we address the hypothesis of MSCs microenvironment extracellular vesicles(MSCs-MEVs)or MSCs microenvironment exosomes(MSCs-MExos)that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications.This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration. | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini | 2019 | Burns & Trauma2019，7，1： | 20 |
| 2 | CO_2 background concentration in the atmosphere over the Chinese mainland显示文摘Based on the long-term monitoring data on CO2 concentration, variation trend and characteristics of CO2 background concentration in the atmosphere over the Chinese mainland are analyzed. Results show that the increasing trend of CO2 background concentration in the atmosphere over the Chinese mainland has appeared during the period of 1991-2000. The average annual CO2 growth increment is 1.59μL/L, and the average annual CO2 growth rate is 0.44%. Distinct seasonal variations of CO2 background concentration are observed, and the averaged amplitude of CO2 seasonal variations is 10.35μL/L. Regional variation characteristics of CO2 background concentration in the atmosphere and possible impact of human activities on these variations over the Chinese mainland are discussed as well. | WANG Gengchen, WEN Yupu, KONG Qinxin, REN Lixin & WANG MulinInstitute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, 100029, China Academy of Meteorological Sciences, China Meteorological Administration, Beijing 100086, China | 2002 | Chinese Science Bulletin2002，47，14： | 9 |
| 3 | Experimental study on the laminar flame speed of hydrogen/natural gas/air mixtures显示文摘Laminar flame speeds of hydrogen/natural gas/air mixtures have been measured over a full range of fuel compositions(0-100%volumetric fraction of H_(2))and a wide range of equivalence ratio using Bunsen burner.High sensitivity scientific CCD camera is use to capture the image of laminar flame.The reaction zone area is employed to calculate the laminar flame speed.The initial temperature and pressure of fuel air mixtures are 293 K and 1 atm.The laminar flame speeds of hydrogen/air mixture and natural gas/air mixture reach their maximum values 2.933 and 0.374 m/s when equivalence ratios equal to 1.7 and 1.1,respectively.The laminar flame speeds of hydrogen/natural gas/air mixtures rise with the increase of volumetric fraction of hydrogen.Moreover,the increase in laminar flame speed as the volumetric fraction of hydrogen increases presents an exponential increasing trend versus volumetric fraction of hydrogen.Empirical formulas to calculate the laminar flame speeds of hydrogen,natural gas,and hydrogen/natural gas mixtures are also given.Using these formulas,the laminar flame speed at different hydrogen fractions and equivalence ratios can be calculated. | Chen DONG Qulan ZHOU Xiaoguang ZHANG Qinxin ZHAO Tongmo XU Shi’en HUI | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 4 |
| 4 | Effects of Long-term Creep at Elevated Temperatures on Rupture Ductility in 9Cr-1Mo-V-Nb-N Steel显示文摘Besides the creep strength, creep ductility has also been recognized as an important material parameter, since low ductility is often associated with notch sensitivity and concomitant prema-ture failure, especially brittle fracture. Creep rupture data of 9Cr-1Mo-V-Nb-N show that the creep ductility decreases with decreasing stress at constant temperatures or with decreasing tem-perature at constant stresses. SEM and TEM were used to investigate the mechanism of creep brittleness. The results indicate that the decrease of rupture ductility after long-term creep is related to the decrease of mobile dislocation density, the coarsening and coalescence of carbides and the decrease of shear lip size. | Zhu, Lihui Zhao, Qinxin Gu, Haicheng Lu, Yansun
| 1998 | Journal of Materials Science & Technology1998，14，3： | 3 |
| 5 | Effects of Exogenous 5-Aminolevulinic Acid and 24-Epibrassinolide on Cd Accumulation in Rice from Cd-Contaminated Soil显示文摘High grain-Cd-accumulating rice variety Yongyou 9 was planted in Cd-contaminated farmland in Taizhou City, Zhejiang Province, China to study the effects of 5-aminolevulinic acid(ALA) and24-epibrassinolide(EBR) on Cd accumulation in brown rice. Results showed that the exogenous ALA and EBR had no significant effects on agronomic traits, soil pH and total Cd content in soil, but had some effects on the available Cd content in soil, and significantly influenced the Cd accumulation in the different parts of rice. Results also showed that 100 mg/L exogenous ALA significantly reduced the Cd accumulation in brown rice to blow the food safety standard(0.2 mg/kg), and also significantly reduced the Cd contents in the roots and culm of rice. However, 200 mg/L exogenous ALA treatment increased the Cd content in brown rice remarkably. In addition, 0.15 mg/L EBR treatment increased Cd accumulation in roots, culm, leaves and brown rice notably, whereas 0.30 mg/L exogenous EBR treatment reduced the Cd accumulation in brown rice properly, but it was not significant. Therefore,proper concentration of ALA can effectively reduce the Cd accumulation in brown rice, which can be used as an effective technical method for the safe production of rice in Cd polluted farmland. | WANG Feijuan ZHANG Yiting GUO Qinxin TAN Haifeng HAN Jiahui LIN Haoran WEI Hewen XU Guangwei ZHU Cheng | 2018 | Rice science2018，25，6： | 3 |
| 6 | The establishment of polypeptide PSMA-targeted chimericantigen receptor-engineered natural killer cells forcastration-resistant prostate cancer and the induction of ferroptosis-related cell death显示文摘Background:The mortality of castration-resistant prostate cancer(CRPC)is high due to lack of an effective treatment.Chimeric antigen receptor(CAR)-based therapy is a promising immunotherapeutic strategy.Here,we aimed to design a novel CAR-natural killer(NK)cells with a clinically significant tumoricidal effect on CRPC.Methods:We constructed novel CAR-NK92MI cells with a CD244-based recombinant lentiviral vector.Different intracellular segments(CD244,NKG2D,or CD3ζ)were screened to identify the best candidate according to cell lysis assay and CD107a expression levels.To enhance the affinity of the CAR to the tumor antigen,we compared an antibody specific for prostate-specific membrane antigen(anti-PSMA)with PSMA-targeted polypeptide(p-PSMA),which was screened by phage display combinatorial library.Then,CAR-NK92MI cells with both a high affinity for PSMA and a strong tumoricidal capacity were generated.In addition,we verified their tumor-killing effect in vitro and in vivo.The release of cytokine by NK92MI cells was compared with that by CAR-NK92MI cells through flow cytometry and enzyme-linked immunosorbent assay.Moreover,ferroptosis-related cell death was explored as a possible underlying mechanism.Results:Three different CAR intracellular regions CAR1(CD244),CAR2(CD244,NKG2D)and CAR3(CD244,NKG2D,and CD3ζ)were constructed.CAR2 was chosen to confer a stronger tumoricidal ability on CAR-NK92MI cells.Compared with anti-PSMA,p-PSMA exhibited enhanced affinity for the tumor antigen.Thus,p-PSMA-CAR-NK92MI cells,which expressed CAR with a polypeptide-based antigen-binding region,an intracellular CD244 and a NKG2D costimulatory domain,were generated.They could selectively and successfully kill PSMA+target cells and exhibited specific lysis rate of 73.19%for PSMA-positive C4-2 cells and 33.04%for PSMA-negative PC3 cells.Additionally,p-PSMA-CAR-NK92MI cells had significantly higher concentrations of IFN-γ,TNF-αand granzyme B than NK92MI cells.In a CRPC cancer xenograft model,p-PSMA-CAR-NK92MI cells significantly inhibited tumor growth and exerted a more consistent killing effect than NK92MI cells.Moreover,ferroptosis is a potential mechanism through which CAR-NK92MI cells attack cancer cells,and is triggered by IFN-γ.Conclusions:p-PSMA-CAR-NK92MI cells can effectively kill CRPCPSMA+cells in vitro and in vivo.This strategy may provide additional treatment options for patients with CRPC. | Liyuan Wu Fei Liu Le Yin Fangming Wang Hui Shi Qinxin Zhao Feiya Yang Dong Chen Xiying Dong Yuchun Gu Nianzeng Xing | 2022 | Cancer Communications2022，42，8： | 2 |
| 7 | Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle显示文摘 | KierstonShill SasisankerPadmanabhan QinXin John M.Prausnitz Douglas S.Clark Harvey W.Blanch | 2011 | Biotechnol Bioeng2011，，3： | 1 |
| 8 | Experimental investigation of heat transfer and pressure drop characteristics of H-type finned tube banks 显示文摘 | Chen Heng Wang Yungang Zhao Qinxin Ma Haidong Li Yuxin Chen Zhongya | 2014 | Energies2014，7，11： | 1 |
| 9 | Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle显示文摘 | KierstonShill SasisankerPadmanabhan QinXin John M.Prausnitz Douglas S.Clark Harvey W.Blanch | 2011 | Bioeng2011，，3： | 1 |
| 10 | Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle显示文摘 | KierstonShill SasisankerPadmanabhan QinXin John M.Prausnitz Douglas S.Clark Harvey W.Blanch | 2011 | Biotechnol Bioeng2011，，3： | 1 |
| 11 | Endovascular Placement of Iodine-125 Seed Strand and Stent Combined with Chemoembolization for Treatment of Hepatocellular Carcinoma with Tumor Thrombus in Main Portal Vein显示文摘 | JianJun Luo ZhiPing Yan QinXin Liu XuDong Qu JianHua Wang | 2011 | Journal of Vascular and Interventional Radiology2011，，4： | 1 |
| 12 | A Study on Chamber Method of in-Situ Measurements of Greenhouse Gases Fluxes in Grassland显示文摘 | Du Rui Wang Gengchen Lu Daren Kong Qinxin Liu Guangren Wan Xiaowei | 2000 | Chinese Journal of Atmospheric Science2000，24，4： | 1 |
| 13 | Mechanism research on coupling effect between dew point corrosion and ash deposition显示文摘 | Wang Yungang Zhao Qinxin Zhang Zhixiang Zhang Zhichao Tao Wenquan | | 0，，01： | 1 |
| 14 | A new approach to convex corner compensation for anisotropic etching of (100) Si in KOH 显示文摘 | ZHANG QINXIN LIU LITIAN LI ZHIJIAN | 1996 | Sensors and Actuators A1996，，56： | 1 |
| 15 | Autonomous bus services:current research status and future recommendations显示文摘Implementing autonomous bus services in several cities has garnered substantial research attention worldwide.However,the benefits and challenges of this emerging mode remain insufficiently understood.Consequently,VOSviewer was employed for a bibliometric analysis involving 300 publications,investigating the associations among authors,journals,and keywords.Subsequently,we comprehensively reviewed the current state of research on two topics and proposed future recommendations.Results indicate that the first document related to autonomous bus services was published in 2009.Most user attitude-related research data are obtained via questionnaires and analyzed using statistical techniques.Autonomous bus services are expected to benefit passengers regarding travel time,cost,safety,etc.,while passenger preferences are inconsistent.However,integrating the service into existing bus systems requires careful consideration of the schedule sequences.Notably,modular autonomous bus services present a new opportunity for the further optimization of bus services.In future studies,standardized data acquisition procedures should be developed to achieve comparable results.Regarding traveler choice behavior,the effect of specific autonomous bus service policies over time and the heterogeneity due to cultural or social contexts across regions should be assessed.To further promote autonomous bus services,based on fluctuating travel demands,the effects of vehicle capacity,speed,and cost of fleet composition should be evaluated comprehensively to optimize the bus network and schedule sequence.Owing to the protracted nature of the transition from conventional to fully autonomous buses,one should prioritize semi-autonomous bus services.Another essential future research direction is to integrate modular autonomous bus assembly or disassembly strategies with different fine-grained operation optimization techniques in various scenarios. | Jinxing Shen Qinxin Liu Zi Ye Wenfeng Jiang Changxi Ma | 2023 | Digital Transportation and Safety2023，2，3： | 1 |
| 16 | Numerical study on laminar flame speed of natural gas-carbon monoxide-air mixtures显示文摘Laminar flame speeds of natural gas-carbon monoxide-air mixtures are calculated by CHEMKIN II with GRI Mech-3.0 over a large range of fuel compositions,equivalence ratios,and initial temperatures.The calculated results of natural gas are compared with previous experimental results that show a good agreement.The calculated laminar flame speeds of natural gas-carbon monoxide-air mixtures show a nonmonotonic increasing trend with volumetric fraction of carbon monoxide and an increasing trend with the increase of initial temperature of mixtures.The maximum laminar flame speed of certain fuel blend reaches its biggest value when there is 92%volumetric fraction of carbon monoxide in fuel at different initial temperatures.Five stoichiometric natural gas-carbon monoxide-air mixtures are selected to study the detailed chemical structure of natural gas-carbon monoxide-air mixtures.The results show that at stoichiometric condition,the fuel blend with 80%volumetric fraction of carbon monoxide has the biggest laminar flame speed,and the C normalized total production rate of methane with 80%volumetric fraction of carbon monoxide is the largest of the five stoichiometric mixtures. | Chen DONG Qulan ZHOU Qinxin ZHAO Tongmo XU Shi’en HUI | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 1 |
| 17 | Power generation expansion planning model towards low-carbon economy and its application in China显示文摘 | Chen Qinxin Kang Chongqing Xia Qing | 2010 | IEEE Trans on Power Systems2010，25，2： | 1 |
| 18 | LC–ESI-MS method for the determination of bisoprolol in human plasma显示文摘 | Li Ding Xia Zhou Xiaofeng Guo Qinxin Song Jianchang He Guili Xu | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，，2： | 1 |
| 19 | A New Approach to Convex Corner Compensation for Anisotropic Etching of (100) Si in KOH显示文摘 | Qinxin Zhang Litian Liu Zhijian Li | 1996 | Sensors and Actuators A1996，，56： | 1 |
| 20 | An internal amplification control for quantitative nucleic acid analysis using nanoparticle-based dipstickbiosensors显示文摘 | Huan Huang Li Jin Xian Yang Qinxin Song Bingjie Zou Shiwen Jiang Lizhou Sun Guohua Zhou | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
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