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| 1 | The good and evil of complement activation in HIV-1 infection显示文摘The complement system,a key component of innate immunity,is a first-line defender against foreign pathogens such as HIV-1.The role of the complement system in HIV-1 pathogenesis appears to be multifaceted.Although the complement system plays critical roles in clearing and neutralizing HIV-1 virions,it also represents a critical factor for the spread and maintenance of the virus in the infected host.In addition,complement regulators such as human CD59 present in the envelope of HIV-1 prevent complement-mediated lysis of HIV-1.Some novel approaches are proposed to combat HIV-1 infection through the enhancement of antibody-dependent complement activity against HIV-1.In this paper,we will review these diverse roles of complement in HIV-1 infection. | Qigui Yu Richard Yu Xuebin Qin | 2010 | Cellular & Molecular Immunology2010，7，5： | 4 |
| 2 | Petrogenesis and Metallogenesis of the Niumaoquan Gabbroic Intrusion Associated with Fe-Ti Oxide Ores in the Eastern Tianshan, NW China显示文摘The Niumaoquan layered gabbroic intrusion is in the southern margin of the Central Asian Orogenic Belt in North Xinjiang, China, and hosts a Fe-Ti oxide deposit in its evolved gabbroic phases. In this paper, we report zircon U-Pb age, Sr-Nd-Hf isotopes, plagioclase chemistry, and whole-rock geochemistry of the Niumaoquan layered gabbroic intrusion. Zircon grains separated from an anorthosite sample analyzed by laser ablation inductively coupled plasma mass spectrometry yielded a concordia age of 314.7±0.74 Ma, indicating that the Niumaoquan ore-bearing gabbroic intrusion was emplaced during the Late Carboniferous. The olivine gabbro texture and plagioclase chemistry suggest that plagioclase was an early crystallized silicate phase that crystallized prior to olivine. Fractional crystallization and accumulation of plagioclase significantly controlled the evolution of the Niumaoquan gabbroic intrusion and contributed to the formation of anorthosite layers, causing metallogenic elements to become enriched in the residual melt. The Niumaoquan gabbroic intrusion is characterized by the enrichment of large ion lithophile elements and depletion of high field strength elements, positive zircon εHf(t) values(+2.1 to +12.2), positive εNd(t) values(+3.3 to +5.2), and low initial ^(87)Sr/^(86)Sr ratios(0.7039 to 0.7047), suggesting that the parental magma was produced by interactions between metasomatized lithospheric mantle and depleted asthenospheric melts at an early post-collision stage. The Fe-Ti oxide mineralization of the Niumaoquan intrusion benefited from interactions between depleted asthenospheric melts and lithospheric mantle, and fractional crystallization of abundant plagioclase and magnesian minerals. | SHI Yu WANG Yuwang WANG Jingbin XIE Hongjing MAO Qigui ZHAO Lutong LONG Lingli LI Dedong ZHOU Guochao | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 3 |
| 3 | Ore-forming Fluid and Mineral Source of the Hongshi Copper Deposit in the Kalatage Area, East Tianshan, Xinjiang, NW China显示文摘The Hongshi copper deposit is located in the middle of the Kalatage ore district in the northern segment of the Dananhu-Tousuquan island-arc belt in East Tianshan, Xinjiang, NW China. This study analyses the fluid inclusions and H, O, and S stable isotopic compositions of the deposit. The fluid-inclusion data indicate that aqueous fluid inclusions were trapped in chalcopyrite-bearing quartz veins in the gangue minerals. The homogenization temperatures range from 108°C to 299°C, and the salinities range from 0.5% to 11.8%, indicating medium to low temperatures and salinities. The trapping pressures range from 34.5 MPa to 56.8 MPa. The δ^(18)O_(H_2O) values and δD values of the fluid range from -6.94‰ to -5.33‰ and from -95.31‰ to -48.20‰, respectively. The H and O isotopic data indicate that the ore-forming fluid derived from a mix of magmatic water and meteoric water and that meteoric water played a significant role. The S isotopic composition of pyrite ranges from 1.9‰ to 5.2‰, with an average value of 3.1‰, and the S isotopic composition of chalcopyrite ranges from -0.9‰ to 4‰, with an average value of 1.36‰, implying that the S in the ore-forming materials was derived from the mantle. The introduction of meteoric water decreased the temperature, volatile content, and pressure, resulting in immiscibility. These factors may have been the major causes of the mineralization of the Hongshi copper deposit. Based on all the geologic and fluid characteristics, we conclude that the Hongshi copper deposit is an epithermal deposit. | YU Mingjie WANG Jingbin MAO Qigui FANG Tonghui ZHANG Rui | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 4 | Zircon SIMS U-Pb Age of the Shaxinan Melagabbro, Eastern Tianshan and Constraints on Fe-Ti-V Oxide Mineralization显示文摘Objective The late Paleozoic Fe-Ti-V oxide deposit of the eastern Tianshan is an important orthomagmatic deposit type in the Central Asia Orogenic Belt(CAOB).A series of Fe-Ti-V oxide deposits and mineralized mafic-ultramafic intrusions have been recognized recently,such as those in Hongliangzi,Weiya,Yaxi,Shaxinan and Shaxi on the Central Tianshan massif,and Niumaoquan on the | SHI Yu WANG Yuwang WANG Jingbin MAO Qigui XIE Hongjing ZHOU Guochao ZHU Jiangjian WEI Xiaofeng Lü Xiaoqiang | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 5 | Polymorphism analysis of microsatellites and construction of linkage map in part regions of four chromosomes in chicken显示文摘Based on chicken' consensus map issued in 2000,17 microsatellites near 4 candidate genes such as IGF2,OBR,GDF8 and APOA1 in 4 chromosomes(chromosome 5,7,8 and 24)were chosen for polymorphism analysis and construction of linkage map.Combining the technique of PCR and the fluorescent semi-automated detection,genome scanning was performed for 440 chickens,which was derived from China Agricultural University chicken resource families within three generations.The individuals of this resource families were genotyped.The results showed that the number of alleles ranged from 4 to 14;heterozygosity(H) of markers was between 0.3116 and 0.9148.Polymorphic information content(PIC)varied from 0.2672 to 0.8679.Microsatellites along with above-mentioned 4 candidate genes doing as general markers were used to construct linkage map.The spans of 4 linkage maps constructed in the part region of chromosome 5,7,8 and 24 were 263.5,79.9,206.2 and 104.2 cM,respectively.The order of markers was consistent with that of counterpart of reported consensus map.However,The spans of linkage map were larger than that of consensus map.The constructed linkage maps laid the foundation for mapping quantitative trait loci(QTL)responsible for economically important traits in chicken. | WANG Shouzhi LI Hui LI Ning GAO Yu DU Zhiqiang GU Zhiliang WANG Qigui LI Zhihui WANG Ying | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，2： | 1 |
| 6 | A High-Affinity Inhibitor of Human CD59 Enhances Complement-Mediated Virolysis of HIV-1 :Implications for Treatment of HIV-1/AIDS显示文摘 | Weiguo Hu Qigui Yu Ningjie Hu | 2010 | Immunol2010，184，： | 1 |
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