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| 1 | Free triiodothyronine level indicates the degree of myocardial injury in patients with acute ST-elevation myocardial infarction显示文摘 | Wang Wen-yao Tang Yi-da Yang Min Cui Cheng Mu Mu Qian Jie Yang Yue-jin | 2013 | Chinese Medical Journal2013，，20： | 21 |
| 2 | Neutrophil-to-lymphocyte ratio compared to N-terminal pro-brain natriuretic peptide as a prognostic marker of adverse events in elderly patients with chronic heart failure显示文摘BackgroundThe neutrophil-to-lymphocyte (N/L ) 比率与心失败在病人与差的预后被联系了,但是它一直不在有长期的心失败(CHF ) 的老病人与 N 终端支持大脑的 natriuretic 肽(NT-proBNP ) 相比。我们寻求了与 CHF 1355 个老病人使这 comparison.MethodsA 全部被分析。multivariate 逻辑回归模型被用来分析与 atrial 纤维性颤动(AF ) 联系的变量。考克斯回归分析被用来估计在 N/L 比率, NT-proBNP 水平,和随后的主要心血管的事件(MCE ).ResultsIn 之间的 multivariable 关系多重逻辑回归分析, N/L 比率与 CHF 在老病人为 AF 作为一个风险因素被表明[机会比率(或) :1.079, 95% 信心间隔(CI ) :1.027-1.134, P = 0.003 ] 。中部的后续时期是 18 个月。在用两个变量的 tertiles 的一个 multivariable 模型, N/L 比率的最高的 tertile 显著地与 MCE 被联系[危险比率(HR ) :1.407, 95% CI:1.098-1.802, P = 0.007 ] 与最低 tertile 相比。同样,最高的 NT-proBNP tertile 显著地也与 MCE 被联系(HR:1.461, 95% CI:1.104-1.934, P = 0.008 ).ConclusionsIn 有 CHF 的老病人, N/L 比率是为 AF 的重要风险因素之一,它是有到 NT-proBNP 的类似的独立预示的力量的一个便宜、容易地可得到的标记。当 N/L 比率被提高到最高的 tertile 时, MCE 的风险增加 1.407 褶层。 | Wei YAN Rui-Jun LI Qian JIA Yang MU Chun-Lei LIU Kun-Lun HE | 2017 | Journal of Geriatric Cardiology2017，14，2： | 20 |
| 3 | Concentrations and gas-particle partitioning of PCDD/Fs in the urban air of Dalian,China显示文摘PCDD/Fs in the urban air of Dalian,China were monitored with high-volume active sampler from November 2009 to October 2010.The concentration of Cl 4-8 DD/Fs ranged from 3065 to 49538 fg m-3,with an average of 10249 fg m-3.The international toxic equivalents(I-TEQ) value of that was 61.8 1182 fg m-3,with an average of 235 fg m-3,which was comparable to those in the other urban locations around the world.It was found that the Cl 4 8 DD/Fs appeared to be present mainly in the particle phase during winter,spring and autumn,while during summer which were dominantly in gas phase.The ratio of Cl 4-8 DD/Fs present in particle phase increased with the increasing level of chlorination.The concentrations of PCDFs and PCDDs decreased with the increase of chlorinated level,while the concentrations of 2,3,7,8-PCDDs congeners increased with the increase of chlorination level.The homolog profiles of the concentrations of PCDFs presented were higher than those of the PCDDs,which indicated the PCDD/Fs pollution source of the air in Dalian was characteristic for thermal source pollution.The correlation analysis of meteorological parameters with the concentrations of Cl 4-8 CDD/Fs was conducted using SPSS packages,and it was found that the ambient temperature and atmospheric pressure were important factors influence the concentration of PCDD/Fs in the air.The respiratory risk and intake dioxins of the residents around the sampling sites were studied in the paper.It was found that Junge-Pankow model was much more accurate in predicting the gas-particle partitioning behavior of PCDD/Fs homologues during winter,while the Harner-Bidleman model shows better agreement with the measured data during winter and summer. | QIN SongTao ZHU XiuHua WANG Wei CHEN JiPing NI YuWen LI XiaoXiao MU Jun Xu Qian SCHRAMM Karl-Werner | 2012 | Chinese Science Bulletin2012，57，26： | 10 |
| 4 | Prediction model of in-hospital mortality in elderly patients with acute heart failure based on retrospective study显示文摘学习是开发在老病人的在里面医院死亡是预兆的一个临床的风险模型的这的 ObjectivesThe 目的与尖锐的心就医了失败(AHF ) 从医院里的心病学部门的特别护理单位 60 岁以上的 .Methods2486 病人被分析。为在里面医院死亡的独立风险因素被二进制逻辑回归获得然后过去常建立风险预言分数系统(RPSS ) 。在接收装置操作符特征和 C 统计数值测试的曲线(AUC ) 下面的区域被采用估计 RPSS 的性能并且与指南心失败(GWTG-HF ) 与以前的 get 作比较 .ResultsBy 二进制代码逻辑回归分析,心率(或:1.043, 95% CI:1.030-1.057, P < 0.001 ) ,左室的喷射部分(或:0.918, 95% CI:0.833-0.966, P < 0.001 ) , pH 价值(或:0.001, 95% CI:0.000-0.002, P < 0.001 ) ,肾的机能障碍(或:0.120, 95% CI:0.066-0.220, P < 0.001 ) 并且 NT 职业人员 BNP (或:3.463, 95% CI:1.870-6.413, P < 0.001 ) 是为老 AHF 病人的在里面医院死亡的独立风险因素。另外, RPSS,它是所有创作了上述参数,比 GWTG-THF 提供了更好的风险预言(AUC:0.873 对 0.818, P = 0.016 ).ConclusionsOur 风险预言模型, RPSS,在老病人为在里面医院死亡向好预言提供了 AHF。 | Qian JIA Yu-Rong WANG Ping HE Xue-Liang HUANG Wei YAN Yang MU Ktm-Lun HE Ya-Ping TIAN | 2017 | Journal of Geriatric Cardiology2017，14，11： | 9 |
| 5 | Dynamic frequency response from electric vehicles in the Great Britain power system显示文摘With the large penetration of renewable energy,fulfilling the balance between electricity demand and supply is a challenge to the modern power system.According to the UK government,the wind power penetration will reach 30%by the year 2020.The role of electric vehicles(EVs)contributing to frequency response was investigated.A dynamic frequency control strategy which considers the comfort level of vehicle owners was developed for EVs to regulate their power consumption according to the deviation of system frequency.A simulation model of a population of EVs equipped with such controlwas implemented inMatlab/Simulink platform.In this paper,a simplified Great Britain power system model is used to study the contribution of EVs to dynamic frequency control.The case study showed that using EVs as a demand response resource can greatly reduce the frequency deviations.And the rapid response from EVs can help reduce the operation cost of conventional generators. | Jian MENG Yunfei MU Jianzhong WU Hongjie JIA Qian DAI Xiaodan YU | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，2： | 8 |
| 6 | Simultaneous monitoring of PCB profiles in the urban air of Dalian,China with active and passive samplings显示文摘The concentration of polychlorinated biphenyls (PCBs) in the urban air of Dalian, China was monitored from November 2009 to October 2010 with active high-volume sampler and semipermeable membrane device (SPMD) passive sampler. The concentration of PCBs (particle + gas) ( ∑ PCBs) ranged from 18.6 to 91.0 pg/m 3 , with an average of 50.9 pg/m 3 , and the most abundant dioxin-like PCB (DL-PCBs) was PCB118. The WHO-TEQ values of DL-PCBs were 3.6-22.1 fg/m3 , with an average of 8.5 fg/m 3 , and PCB126 was the maximum contributor to ∑ TEQ. There was a much larger amount of PCBs in the gas phase than in the particulate phase. The dominant PCB components were lower and middle molecular weight PCBs. With increasing chlorination level, the concentration of the PCB congeners in the air decreased. The gas-particulate partitioning of PCBs was different for the four seasons. The gas- particulate partitioning coefficients (logK p ) vs. subcooled liquid vapor pressures (logP L 0 ) of PCBs had reasonable correlations for different sampling sites and seasons. The absorption mechanism contributed more to the gas-particulate partitioning process than adsorption. Correlation analysis of meteorological parameters with the concentration of PCBs was conducted using SPSS packages. The ambient temperature and atmospheric pressure were important factors influencing the concentration of PCBs in the air. The distribution pattern of the congeners of PCBs and the dominant contributors to DL-PCBs and TEQ in active samples and SPMDs passive samples were similar. SPMD mainly sequestrated gas phase PCBs. | Qian Xu Xiuhua Zhu Bernhard Henkelmann Karl-Werner Schramm Jiping Chen Yuwen Ni Wei Wang Gerd Pfister Jun Mu Songtao Qin Yan Li | 2013 | Journal of Environmental Sciences2013，25，1： | 8 |
| 7 | Influence of Positive and Negative Indian Ocean Dipoles on ENSO via the Indonesian Throughflow: Results from Sensitivity Experiments显示文摘The role of the Indonesian Throughflow(ITF) in the influence of the Indian Ocean Dipole(IOD) on ENSO is investigated using version 2 of the Parallel Ocean Program(POP2) ocean general circulation model. We demonstrate the results through sensitivity experiments on both positive and negative IOD events from observations and coupled general circulation model simulations. By shutting down the atmospheric bridge while maintaining the tropical oceanic channel, the IOD forcing is shown to influence the ENSO event in the following year, and the role of the ITF is emphasized. During positive IOD events,negative sea surface height anomalies(SSHAs) occur in the eastern Indian Ocean, indicating the existence of upwelling.These upwelling anomalies pass through the Indonesian seas and enter the western tropical Pacific, resulting in cold anomalies there. These cold temperature anomalies further propagate to the eastern equatorial Pacific, and ultimately induce a La Nia-like mode in the following year. In contrast, during negative IOD events, positive SSHAs are established in the eastern Indian Ocean, leading to downwelling anomalies that can also propagate into the subsurface of the western Pacific Ocean and travel further eastward. These downwelling anomalies induce negative ITF transport anomalies, and an El Nio-like mode in the tropical eastern Pacific Ocean that persists into the following year. The effects of negative and positive IOD events on ENSO via the ITF are symmetric. Finally, we also estimate the contribution of IOD forcing in explaining the Pacific variability associated with ENSO via ITF. | ZHOU Qian DUAN Wansuo MU Mu FENG Rong | 2015 | Advances in Atmospheric Sciences2015，32，6： | 6 |
| 8 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 9 | Influence of gallic acid on porcine neutrophils phosphodiesterase 4,IL-6,TNF-α and rat arthritis model显示文摘Our previous studies showed that the anti-inflammatory effects of Paeonia lactiflora roots extract may be mediated, at least in part, through its gallic acid content, and this effect may be regulated in part by an inhibition on c AMP-phosphodiesterase(PDE). To explore the anti-inflammatory effect and mechanism, the influence of gallic acid on neutrophils PDE4 activity and expression, TNF-α and IL-6 content and rat arthritis model were further studied. PDE4 activity and gene express were calculated respectively by substrate c AMP change examined with HPLC and real-time RT-PCR. The concentration of IL-6 and TNF-α in supernatant were assayed by ELISA method. Model of rat arthritis was caused by complete Freund's adjuvant. Results showed that gallic acid had a dose-dependent restraint on PDE4 activity of neutrophils in vitro, promoted significantly PDE4 A expression(P<0.01), and had no influence on the expressions of PDE4 B and 4D. However, PDE4 C expression was not detected. Gallic acid could promote IL-6 release(P<0.05), and inhibit TNF-α release of neutrophils(P<0.05). The experiment in vivo showed that gallic acid had obvious restraint on local inflammation of animal model(P<0.05). Therefore, the anti-inflammatory effect of gallic acid may be mediated in part through an inhibition on PDE4 activity and further an increase of IL-6 and a decrease of TNF-α of neutrophils, and this effect seemed to have no relationship with PDE4 expression. | JIANG Dai-xun ZHANG Mei-hua ZHANG Qian CHEN Yi-shan MA Wen-jing WU Wei-peng MU Xiang CHEN Wu | 2015 | Journal of Integrative Agriculture2015，14，4： | 5 |
| 10 | Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest显示文摘Eriocalyxin B,an ent-Kaurene diterpenoid extracted from a traditional Chinese herb Isodon eriocalyx,has been shown to possess multifunctional activities such as anti-cancer and anti-inflammatory.However,the function and mechanism of the compound in adipocyte differentiation is still unknown.Here we reported that eriocalyxin B blunted adipogenesis remarkably by inhibiting the accumulation of lipid droplets,triglycerides and the expressions of adipogenesis-related factors,including C/EBPβ,C/EBPα,PPARγ,and FABP4.Moreover,we showed that the inhibition might be the consequence of cell cycle being arrested at the G2/M phase during the mitotic clonal expansion of adipocyte differentiation,most likely by suppress-ing mRNAs and proteins of CDK1,CDK2,Cyclin A and Cyclin B1.Overall,we conclude that eriocalyxin B is capable of inhibiting adipocyte differentiation at the early stage through downregulating the proteins involved in cell cycle progression. | Rong-Fang Mu Yan-Fen Niu Qian Wang Hui-Min Zhou Jing Hu Wan-Ying Qin Wen-Yong Xiong | 2020 | Natural Products and Bioprospecting2020，10，3： | 3 |
| 11 | Numerical study of M_2 internal tide generation and propagation in the Luzon Strait显示文摘Based on the z-coordinate ocean model HAMSOM,we introduced the internal-tide viscosity term and applied the model to numerically investigate the M2 internal tide generation and propagation in the Luzon Strait (LS).The results show that (1) in the upper 250 m depth,at the thermocline,the maximum amplitude of the generated internal tides in the LS can reach 40 m;(2) the major internal tides are generated to the northwest of Itbayat Island,the southwest of Batan Island and the northwest of the Babuyan Islands;(3) during the propagation the baroclinic energy scattering and reflection is obvious,which exists under the effect of the specific topography in the South China Sea (SCS);(4) the westward-propagating internal tides are divided into two branches entering the SCS.While passing through 118 E,the major branch is divided into two branches again.The strongest internal tides in the LS are generated to the northwest of Itbayat Island and propagate northeastward to the Pacific.However,to the east of 122 E,most of the internal tides propagate southeastward to the Pacific as a beam. | LI Huan SONG Dan CHEN Xueen QIAN Hongbao MU Lin SONG Jun | 2011 | Acta Oceanologica Sinica2011，30，5： | 3 |
| 12 | A new cell death program regulated by toll-like receptor 9 through p38 mitogen-activated protein kinase signaling pathway in a neonatal rat model with sepsis associated encephalopathy显示文摘Background:Sepsis,a serious condition with high mortality,usually causes sepsis associated encephalopathy(SAE)that involves neuronal cell death.However,the cell death programs involved and their underlying mechanisms are not clear.This study aimed to explore the regulatory mechanisms of different cell death programs in SAE.Methods:A neonatal rat model of SAE was established by cecal ligation and perforation.Survival rate and vital signs(mean arterial pressure and heart rate)were monitored,nerve reflexes were evaluated,and cortical pathological changes were observed by hematoxylin and eosin staining.The expression of pyroptosis,apoptosis,and necroptosis(PANoptosis)-related proteins,mitogen-activated protein kinase(MAPK),and its upstream regulator toll-like receptor 9(TLR9)were detected.The expression of TLR9 in neurons was observed by immunofluorescence staining.The ultrastructure of neurons was observed by transmission electron microscope.Results:First,PANoptosis was found in cortical nerve cells of the SAE rats.Meanwhile,the subunits of MAPKs,p38 MAPK,Jun N-terminal kinase,and extracellular signal-regulated kinase(ERK)were activated.After pharmacologically inhibiting each of the subunits,only p38 MAPK was found to be associated with PANoptosis.Furthermore,blocking the p38 MAPK signaling pathway activated necroptosis but inhibited apoptosis and pyroptosis.When necroptosis was pharmacologically inhibited,apoptosis and pyroptosis were reactivated.Finally,we found that the expression of TLR9,a regulator of MAPKs,was significantly increased in this model.After down-regulation of TLR9,p38 MAPK,and ERK signaling pathways were inhibited,which led to the inhibition of PANoptosis.Further analysis found that down-regulation of TLR9 improved the survival rate and reduced the pathological changes in SAE rats.Conclusions:Our study showed that the programs comprising PANoptosis are activated simultaneously in SAE rats.TLR9 activated PANoptosis through the p38 MAPK signaling pathway.TLR9 may work as a potential target for SAE treatment. | Ruixi Zhou Junjie Ying Xia Qiu Luting Yu Yan Yue Qian Liu Jing Shi Xihong Li Yi Qu Dezhi Mu | 2022 | Chinese Medical Journal2022，，12： | 3 |
| 13 | Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells显示文摘RNAi interference(RNAi)is an evolutionarily conserved post-transcriptional gene silencing mechanism and has been well recognized as an important antiviral immunity in eukaryotes.Numerous viruses have been shown to encode viral suppressors of RNAi(VSRs)to antagonize antiviral RNAi.Hepatitis C virus(HCV)is a medically important human pathogen that causes acute and chronic hepatitis.In this study,we screened all the nonstructural proteins of HCV and found that HCV NS2 could suppress RNAi induced either by small hairpin RNAs(shRNAs)or small interfering RNAs(siRNAs)in mammalian cells.Moreover,we demonstrated that NS2 could suppress RNAi via its direct interaction with doublestranded RNAs(dsRNAs)and siRNAs,and further identified that the cysteine 184 of NS2 is required for the RNAi suppression activity through a serial of point mutation analyses.Together,our findings uncovered that HCV NS2 can act as a VSR in vitro,thereby providing novel insights into the life cycle and virus-host interactions of HCV. | Hui Zhou Qi Qian Ting Shu Jiuyue Xu Jing Kong Jingfang Mu Yang Qiu Xi Zhou | 2020 | Virologica Sinica2020，35，4： | 3 |
| 14 | Research on the Necessity of Building National-level Grape and Cherry Germplasm Resources Bank in Shandong Province显示文摘At present,the grape and cherry industries in Shandong are in the leading position in China and have driven the development of related high-end manufacturing industries such as wine,brandy,preserved fruit processing,fruit juice processing and health products. Therefore,vigorously developing the grape and cherry industries in Shandong Province and carrying out development and innovation are important parts of Shandong Province in responding to the strategy of national new and old kinetic energy conversion. However,currently the germplasm resources preserved in the fruit tree resources banks in China are only 45% of those in the US and 27. 2% of those in the EU. Moreover,the development of fruit trees resources banks in Shandong is relatively backward in China,and there is still no banks related with grape and cherry germplasm resources in Shandong. Therefore,importance can be attached to the agriculture,forestry,and animal husbandry to build germplasm resources banks for grape and cherry industries in Shandong Province. Building the national-level grape and cherry germplasm resources bank in Shandong Province can also promote the utilization of wild and farm germplasm resources in the future; advance the research on the genes related to disease resistance,stress resistance and quality of grapes and cherries; push forward the construction and development of cherry and grape mutants banks. It is conducive to the research on the agronomic traits of grapes and cherries,and can provide the parents resources for planting innovation and improving the quality of grapes and cherries,as well as promote the development and application of molecular markers of grapes and cherries,including the identification of lines and crossbreeding. Thereby,it cannot only promote the industry development,but also achieve the development of cultivation,breeding and basic research in an all-round way and the development of ' production,study and research' going side by side. | Pengfei WANG Fengshan REN Yongmei WANG Xinying WU Xilong JIANG Yingchun CHEN Shan WANG Qian MU Liying YANG Wanjun CHEN | 2018 | Agricultural Biotechnology2018，7，2： | 3 |
| 15 | Identification of the miniature pig inbred line by skin allograft显示文摘Skin grafting has been used as one of the most reliable tests to determine the genetic stability of laboratory animal such as mice and rats inbred line, but no identification of swine inbred lines by skin grafting has been reported. At present, Wuzhishan miniature pig(WZSP) inbred line has acquired the F24 individuals in China. In order to verify whether WZSP inbred line had been cultivated successfully, allogeneic skin grafts and related research were performed on F20 individuals of WZSP inbreeding population, compared with a control group of autologous transplantation. We observed the transplant recipients' wounds, detected peripheral blood-related indicators interleukin-2, 4 and 10, CD4+ and CD8+ lymphocytes, and conducted hematoxylin-eosin(HE) and Masson's staining of skin to judge whether the immune rejection reactions occurred within 28 days after transplantation. Chr. 7 genomic heterozygosity of 48 WZSP individuals from F20 to F22 was analyzed by high-density single nucleotide polymorphism(SNP) chips(60 000 SNPs). The result showed that there were no significant differences in graft skin, the plasma interleukin-2, 4, 10, CD4+ and CD8+, HE and Masson's staining results between the allograft and autograft groups, and no immune rejection occurred on the allograft group. We found that 11 genes in Chr. 7 of major histocompatibility complex(MHC) I and MHC II were homozygous which confirmed that immune antibody of the allograft and autograft groups were highly identical and also provided a theoretical basis to no immune rejection occurred on the allograft in the inbred WZSP. The result proved that the WZSP inbred line had been cultivated successfully for the first time in the world. The test methods also provide a scientific basis for the identification of swine and mammal inbred lines. | MU Yu-lian LIU Lan FENG Shu-tang WU Tian-wen LI Kui LI Jun-you HE Wei GAO Qian ZHOU Wen-fang WEI Jing-liang TANG Fang YANG Shu-lin WU Zhi-gu XIA Ying SUN Tong-zhu | 2015 | Journal of Integrative Agriculture2015，14，7： | 2 |
| 16 | PNPLA5-knockout rats induced by CRISPR/Cas9 exhibit abnormal bleeding and lipid level显示文摘Patatin-like phospholipase domain containing 5(PNPLA5) is a neotype neutral lipase with dual activity of anabolism and catabolism in vitro and in vivo,which has a low mRNA expression level in humans and mice.PNPLA5,which is localized to lipid droplets and required for efficient autophagy by optimal initiation,has been speculated to possess triglyceride hydrolase activity,and has been associated with low density lipoprotein cholesterol(LDL-C).Above all,PNPLA5 is a relatively new gene,which is reported less about its biological function research,especially the function research in the rats is still blank.In this study,we examined the spatiotemporal expression profile of PNPLA5 and found that it was expressed at low levels in most organs of Sprague Dawley(SD) rats,but was present at very high levels in the skin and testes.To further determine the biological function of PNPLA5 in mammals,we generated PA/PL45-knockout SD rats using the clustered regularly-interspaced short palindromic repeats(CRISPR)/Cas9 system.PA/PL45-null rats were viable,but showed a variety of phenotypic abnormalities,such as abnormal bleeding,and varied hematobiochemical parameters including increased serum total cholesterol(TC),triglycerides and high density lipoprotein cholesterol(HDL-C) level,and reduced LDL-C level,compared with wild-type control rats.These data are consistent with an important role for PNPLA5 in lipid metabolism,providing a new target gene and animal model for treatment of cardiovascular diseases in the future. | LIU Yang GAO Qian ZHANG Xue HUANG Lei XU Kui HU Yan-qing LIU Lan MU Yu-lian LI Kui | 2017 | Journal of Integrative Agriculture2017，16，1： | 2 |
| 17 | Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China显示文摘 | Gu Jun Li Maolan Dong Ping Lu Jianhua Tan Zhujun Wu Xiangsong Mu Jiasheng Zhang Lin Wu Wenguang Ding Qichen Yang Jiahua Cao Yang Ding Qian Weng Hao Liu Yingbin | 2014 | Chinese Medical Journal2014，，3： | 2 |
| 18 | Regulation of mATG9 trafficking by Src- and ULK1mediated phosphorylation in basal and starvation-induced autophagy显示文摘Autophagy 要求多样的膜来源并且包含 mATG9 的膜 trafficking,在 ATG 家庭的唯一的膜蛋白质。然而,为 autophagy 开始的 mATG9 trafficking 的分子的规定仍然保持不清楚。这里,我们识别了在 mATG9 的 cytosolic N 终点以内排序信号的二保存经典适配器蛋白质,它调停从经由和 AP1/2 建筑群的相互作用的血浆膜和 trans-Golgi 网络(TGN ) 的 mATG9 的 trafficking。在 Tyr8 到的 Src phosphorylates mATG9 处于不着重的条件维持它的 endocytic 和组成的 trafficking。响应饥饿,在由 Src 的 Tyr8 并且在由 ULK1 的 Ser14 的 mATG9 的 phosphorylation 机能上地合作支持在 mATG9 和 AP1/2 建筑群之间的相互作用,为 autophagy 从血浆膜和 juxta 原子的区域导致 mATG9 的再分配到外部水池开始。我们的调查结果揭开 mATG9 trafficking 的新奇机制并且建议基础、导致压力的 autophagy 的协作。 | Changqian Zhou Kaili Ma Ruize Gao Chenglong Mu Linbo Chen Qiangqiang Liu Qian Luo Du Feng Yushan Zhu Quan Chen | 2017 | Cell Research2017，27，2： | 2 |
| 19 | Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain显示文摘Objective This study aimed to investigate the expression pattern and function of Nuclear receptor subfamily 2 group E member 1(Nr2e1) in retinoic acid(RA)-induced brain abnormality. Methods The mouse model of brain abnormality was established by administering 28 mg/kg RA, and neural stem cells(NSCs) were isolated from the mouse embryo and cultured in vitro. Nr2e1 expression was detected by whole mount in situ hybridization, RT-PCR, and Western blotting. Nr2e1 function was determined by transducing Nr2e1 shRNA into NSCs, and the effect on the sonic hedgehog(Shh) signaling pathway was assessed in the cells. In addition, the regulation of Nr2e1 expression by RA was also determined in vitro. Results Nr2e1 expression was significantly downregulated in the brain and NSCs of RA-treated mouse embryos, and knockdown of Nr2e1 affected the proliferation of NSCs in vitro. In addition, a similar expression pattern of Nr2e1 and RA receptor(RAR) α was observed after treatment of NSCs with different concentrations of RA. Conclusion Our study demonstrated that Nr2e1 could be regulated by RA, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality. | YU Juan GUO Qian MU Jian Bing ZHANG Ting LI Ren Ke XIE Jun | 2017 | Biomedical and Environmental Sciences2017，30，3： | 2 |
| 20 | An analysis of drag force on wind of shrubs simulated in a wind tunnel显示文摘 | Ping Lv Zhibao Dong Qingsong Mu Wanyin Luo Guangqiang Qian | 2014 | Environmental Earth Sciences2014，，1： | 2 |
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