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| 1 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 2 | New option of MBR-RO process for production of NEWater from domestic sewage显示文摘 | QinJ J Kekre K A Tao G H | 2006 | J Mem Sci2006，272，： | 1 |
| 3 | Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells显示文摘 | LiuX QinJ LuoQ etal | 2013 | J Cell Mol Me2013，17，9： | 1 |
| 4 | Value of multi-quadrants biopsy:Pooled analysis of 11 population-based cervical cancer screening studies显示文摘Objective:The accuracy of colposcopy-guided biopsy is key to the success of colposcopic triage in cervical cancer screening programs.However,there is no widely adopted biopsy guideline up to date.Our study aimed to determine whether multi-quadrants biopsy improves the yield of cervical lesions.Methods:Eleven population-based cervical cancer screening studies were conducted in China.Cytology,highrisk human papillomavirus(hrHPV)testing and visual inspection were performed for primary screening.Females positive on one or more tests were referred for colposcopy and biopsy.The proportion of detected cervical intraepithelial neoplasia(CIN)2+and yields by quadrant lesion-targeted biopsy or 4-quadrant random biopsy were compared.Results:Among 4,923 females included,1,606 had quadrant lesion-targeted biopsy,and 3,317 had 4-quadrant random biopsy.The cumulative CIN2+yield increased from 0.10 for only one quadrant-targeted biopsy to 0.21,0.34,and 0.58 for at most two,three and four quadrants targeted biopsies.Among hrHPV positive females with high-grade squamous intraepithelial lesion(HSIL)+cytology,the cumulative CIN2+yield of a second targeted biopsy in another quadrant was significantly increased(P<0.05).Among hrHPV-negative females,the yield of 4-quadrant random biopsies was 0.005,and the yield by lesion-targeted biopsies was 0.017.For hrHPV positive females who had 4-quadrant random biopsy,the additional CIN2+yield for HSIL+,low-grade squamous intraepithelial lesion(LSIL)cytology,or abnormal visual inspection via acetic acid and Lugol’s iodine(VIA/VILI)were 0.46,0.11,0.14.Conclusions:A 4-quadrant random biopsy is recommended only for hrHPV positive females with HSIL cytology,and is acceptable if hrHPV positive with LSIL cytology or with abnormal VIA/VILI.Our findings add evidences for an objective and practical biopsy standard to guide colposcopy in cervical cancer screening programs in low-and middle-income countries. | Yuqian Zhao Fanghui Zhao Shangying Hu Xun Zhang Wenhua Zhang Qinjing Pan Julia C Gage Rengaswamy Sankaranarayanan Youlin Qiao | 2020 | Chinese Journal of Cancer Research2020，32，3： | 1 |
| 5 | A metagenome-wide association study ofgut microbiota in type 2 diabetes 显示文摘 | QinJ Li Y Cai Z | 2012 | Nature2012，490，7418： | 1 |
| 6 | PTENinhibitsmacrophagepolarizationfromM1toM2throughCCL2andVEGF-AreductionandNHERF-1synergism显示文摘 | LIN QINJ LANL etal | 2015 | CancerBiolTher2015，16，2： | 1 |
| 7 | Slab Breakoff Model for the Triassic Post-Collisional Adakitic Granitoids in the Qinling Orogen, Central China: Zircon U - Pb Ages, Geochemistry, and Sr- Nd - Pb Isotopic Constrains 显示文摘 | QinJ F LiaSC LiYF | 2008 | International Geological Review2008，50，： | 1 |
| 8 | Up-regulation ofp21WAFl/Ciplby saRNA induces Gl-phase arrest and apoptosis in T24 human bladder cancer cells显示文摘 | Yang K Zheng X Y QinJ el al | 2008 | CaneerLett2008，265，1： | 1 |
| 9 | Differenceoftolerancetolowtemperatureandlightintensityinfiverootstockvarietiesofsweetpepper[J]显示文摘 | WANGHongtao(王洪涛) AIXizhen(艾希珍) QINJing(秦竞) | | AetaAgricuhuraeBorealioccidentalisSinica0，，： | 1 |
| 10 | Identification of a novel family of BRAF( V600E) inhibitors显示文摘 | QinJ Xie P Ventocilla C | 2012 | ] Med Chem2012，55，： | 1 |
| 11 | Statistical optimization of medium components for enhanced acetoin production from molasses and soybean显示文摘 | Xiao ZJ Liu P H QinJ Y | 2007 | Appl Microbiol Biotechnol2007，74，： | 1 |
| 12 | The effect of heat treatment on microstructure and fracture toughness of in situ synthesized (TiB+La2O3)/Ti composite显示文摘 | LIJX WANGLQ QinJ N | 2011 | Materials Transactions2011，52，9： | 1 |
| 13 | A human gut microbial gene cat-alogue established by metagenomic sequencing显示文摘 | QINJ LI R RAESJ | 2010 | Nature2010，464，7285： | 1 |
| 14 | Native fluorescence detection of flavin derivatives by microchip capillary electrophoresis with laserindnced fluorescence intensified charge coupled device detection 显示文摘 | QinJ H Fung Y S Zhu D R | 2004 | J Chromatogr raphy A2004，，1027： | 1 |
| 15 | The land-sourced pollution in the Jisozhou bay显示文摘 | Gao Z Yang D QinJ | 2008 | Chinese Journal of Oceanology and Limnotogy2008，26，： | 1 |
| 16 | New option of MBR-RO process for production of NEWater from domestic sewage 显示文摘 | QinJ J Kekre K A Tao G H | 2006 | J Membrane Sci2006，272，12： | 1 |
| 17 | 320-detector CT coronary angiog?raphy with prospective and retrospective electrocardiogram gating in a single heartbeat: comparison of image quality and radiation dose显示文摘 | QinJ Liu LY Fang Y | 2012 | BrJ Hadiol2012，85，1015： | 1 |
| 18 | ProteomicanalysisofelitesoybeanJidou17anditsparentsusingiTRAQ-basedquantitativeapproaches显示文摘 | QinJ GuF LiuD etal | 2013 | ProteomeScience2013，11，： | 1 |
| 19 | Plateletintegrinalpha (IIb ) beta ( 3 ) : activation- mechanisms 显示文摘 | MaYQ QinJ PlowEF | 2007 | JThrombHaemost2007，5，： | 1 |
| 20 | Uncovering the dark web: A case study ofJihad on the web显示文摘 | Chen H Chung W QinJ | 2008 | Journal of the American Society for Information Science and Technology2008，59，8： | 1 |
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