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| 1 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 2 | 生物起搏器:从生物实验到计算机模拟显示文摘起搏功能障碍已成为威胁人类健康的一种重大疾病,严重时可能导致心律失常、晕厥,甚至死亡。到目前为止,治疗起搏功能障碍的最佳方案是植入电子起搏器。但是它存在一些缺点,例如电池寿命有限,手术过程具有感染的风险,起搏频率单一等。因此,对生物起搏器的研究显得尤为迫切。生物起搏器不但引起并发症的风险较低,而且能够对生理情绪做出反应,从而有望替代电子起搏器,进行心脏起搏障碍治疗。本文从生物实验和计算机模拟两方面对生物起搏器的发展进行综述。前者主要包括基因疗法和细胞疗法的实验成果,而后者介绍了多尺度的心脏建模从单个细胞到组织切片进行起搏器研究的进展。迄今为止,生物起搏器已被应用于大型哺乳动物实验,但将其应用于临床心脏病治疗,仍有很长的路要走。利用计算机模型对生物起搏器诱发过程进行建模,有望加速研究进程。在本文中,我们首先回顾了生物起搏器实验研究的发展,然后介绍了生物起搏器计算机模型的目前的相关工作。最后,我们提出了基于心脏计算机模型研究生物起搏器的潜在研究方向。 | Yacong LI Kuanquan WANG Qince LI Henggui ZHANG | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，7： | 1 |
| 3 | Tuning the Electrical and Optical Properties of Diketopyrrolopyrrole Complexes for Panchromatic Dye-Sensitized Solar Cells显示文摘 | Qu S Y QinC J Ashraful Islam | | 0，，12： | 1 |
| 4 | Differential effects of urinary bladder distension on high cervical projection neurons in primates 显示文摘 | ChandlerMJ QinC ZhangJ | 2002 | Brain Res2002，949，12： | 1 |
| 5 | Neurochemical plasticity in the entericnervous system of a primate animal model of experi-mental Parkinsonism 显示文摘 | Chaumette T Lebouvier T Aubert P Lardeux B QinC Li Q | 2009 | Neurogastroenterol Motil2009，21，： | 1 |
| 6 | New One- dimensional Imidazole-bridged Cadmium( 11 ) Coordi- nation Polymers-syntheses, Crystal Structures and Photoluminescence显示文摘 | WANGXL QINC WANGEB etal | 2005 | Journal of Molecular Struc- ture2005，749，1： | 1 |
| 7 | Lowbloodpressureandriskofdementiainthekungsholmenproject:A6yearsfollow-upstudy显示文摘 | QinC VonSE FastbomJ atal | 2003 | ArchNeurol2003，60，2： | 1 |
| 8 | Developmentofselectivearylhydro-carbonreceptormodulatorsfortreatmentofbreastcancer显示文摘 | SafeS QinC McDougalA | 1999 | Ex-pertOpinInvestigDrugs1999，8，9： | 1 |
| 9 | Cytogeneticanalysisof531Chinese women with premature ovarian failure 显示文摘 | JiaoX QinC LiJ etal | 2012 | Hum Reprod2012，27，7： | 1 |
| 10 | Soy isoflavone intake increases bone mineral density in the spine of menopausal women: meta-analysis of randomized controlled trials显示文摘 | MA Defu QINC Liqiang WANGA Peiyu | 2008 | Clin Nutr2008，27，1： | 1 |
| 11 | Comparative proteomic analysis of Vibrio cholerae O139, O22, O155 and El Tor biotype epidemic strains显示文摘The purposes of this study are to compare the proteome of Vibrio cholerae O139 strains with that of O22, O155 and El Tor biotype epidemic strains, and to identify whether O139 strains have a close relation with the latter. Proteins of two V.cholerae serogroup O139 strains, two El Tor biotype epidemic strains, one O22 strain, and one O155 strain were separated by two-dimensional gel electrophoresis (2-DE); the silver stained 2-DE gels were scanned with digital ImageScanner and analyzed with ImageMaster 2D Elite 3.10 software. Similarities of protein maps between these strains were analyzed. The two O139 strains had 86% proteins in common; the two El Tor biotype epidemic strains showed 84% proteins in common; O139 strains shared 67%, 47% and 45% proteins with El Tor biotype epidemic strains, O22 and O155 strains respectively. Although the proteome of O139 strains have close similarity to that of El Tor biotype epidemic strains, great disparities exist. O139 strains may not originate from El Tor biotype directly, and a transition strain may exist. | QING HUA ZOU Bo QINC LI JIAN ZHONG ZHANG | 2005 | Journal of Microbiology and Immunology2005，3，2： | 0 |
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