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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Awakening concentration of desflurane is decreased in patients with obstructive jaundice显示文摘 | Song JG Cao YF Yang LQ Yu WF Li Q Song JC Fu XY Fu Q | 2005 | 第二军医大学学报2005，26，8： | 15 |
| 3 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 4 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 5 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 6 | 头颈癌患者的体质指数和预后显示文摘体质指数(BMI)与头颈癌结局相关性差异显著。该文旨在评估BMI与诊断或早期成人头颈癌结果之间的相关性。纳入研究的样本为加拿大多伦多玛格丽特王子肿瘤中心头颈鳞癌患者,检测指标包括烟草和酒精的使用、病情状态、并发症及BMI指数。 | Gama RR Song Y Zhang Q 张凌 | 2017 | 中国口腔颌面外科杂志2017，15，3： | 2 |
| 7 | Synthesis and structural characterization of several tris(2-methyl-2-phenylpropyl)tin carboxylates contanining germanium显示文摘 | Fang X N Song X Q Xie Q L | | 0，，： | 2 |
| 8 | Genetic variations of the paraoxonase gene in patients with coronary artery disease显示文摘 | Seung Ho Hong Junghan Song Won Ki Min Jin Q Kim | 2001 | Clinical Biochemistry2001，，6： | 2 |
| 9 | 人乳头瘤病毒16型E6通过下调NHERF1基因促进宫颈癌细胞迁移和侵袭显示文摘高危型人乳头瘤病毒(HPV)E6的PDZ结合基序(PBM)在宫颈癌的发生、发展中起重要作用。HPV16 E6通过其PBM区与Na+/H+交换器调节因子1(NHERF1)相互作用,并诱导NHERF1降解。NHERF1通过下调辅肌动蛋白α4(ACTN4)的表达来延缓细胞骨架的组装,从而抑制宫颈癌细胞在细胞和小鼠模型中的迁移和侵袭。HPV16 E6通过下调NHERF1的表达,提高了ACTN4水平,促进了肌动蛋白聚合,增强了宫颈癌细胞的迁移和侵袭能力。宫颈癌标本的基因集富集分析还表明,HPV16 E6与肌动蛋白细胞骨架组装显著相关,而HPV18 E6没有发现此种关联。HPV16 E6下调NHERF1基因促进细胞骨架组装和细胞侵袭,是宫颈癌发生发展的重要原因。 | Wang Q Song R Zhao C 高雯(编译) | 2020 | 中华预防医学杂志2020，54，1： | 2 |
| 10 | Study on the phase behavior of cholesterol-acetone-CO2 system and recrystallization of cholesterol by antisolvent 显示文摘 | Liu Z M Wang J Q Song L P | 2002 | J Supercrit Fluids2002，24，： | 2 |
| 11 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water 显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catal Lett2006，109，： | 1 |
| 12 | Performance improvement of pasted nickel electrodes with an addition of ball-milled nickel hydroxide powder显示文摘 | SONG Q CHILI C CHAN S | 2006 | Eleetroehim Aeta2006，51，： | 1 |
| 13 | Novel chemical method for synthesis of LiV3 O8 nanorods as cathode materials for lithium ion batteries 显示文摘 | Xu H Y Wang H Song Z Q | 2004 | Electrochimica Acta2004，49，2： | 1 |
| 14 | Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing显示文摘 | LUO Q KANG Q SONG W X | 2007 | Gene2007，395，12： | 1 |
| 15 | Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population:the stroke prevention in young women study显示文摘 | Cole JW O'Connell JR | 2006 | Hum Mol Genet2006，15，： | 1 |
| 16 | cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rat with dorsal root ganglia compression显示文摘 | Song X J Wang Z B Gan Q | 2006 | J Neurophysiol2006，95，1： | 1 |
| 17 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catalysis Letters2006，109，12： | 1 |
| 18 | cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperal- gesia in rats with dorsal root ganglia compression 显示文摘 | SONG XJ WANG ZB GAN Q | 2006 | J Neurophysiol2006，95，1： | 1 |
| 19 | Proline metabolism and cross-tolerance to salinity and heat stress in germinating wheat seeds显示文摘 | Song S Q Lei Y B Tian X R | 2005 | Russian Journal of Plant Physiology2005，52，6： | 1 |
| 20 | Multicycle study on chemical-looping combustion of simulated coal gas with a CaSO4 oxygen carrier in a fluidized bed reactor显示文摘 | SONG Q XIAO R DENG Z ZHENG W SHEN L XIAO J | 2008 | Energy Fuels2008，22，6： | 1 |
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