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| 1 | Interventional strategies in infected necrotizing pancreatitis:Indications,timing,and outcomes显示文摘Acute pancreatitis(AP)is one of the most common gastrointestinal diseases and remains a life-threatening condition.Although AP resolves to restitutio ad integrum in approximately 80%of patients,it can progress to necrotizing pancreatitis(NP).NP is associated with superinfection in a third of patients,leading to an increase in mortality rate of up to 40%.Accurate and early diagnosis of NP and associated complications,as well as state-of-the-art therapy are essential to improve patient prognoses.The emerging role of endoscopy and recent trials on multidisciplinary management of NP established the“step-up approach”.This approach starts with endoscopic interventions and can be escalated to other interventional and ultimately surgical procedures if required.Studies showed that this approach decreases the incidence of new multiple-organ failure as well as the risk of interventional complications.However,the optimal interventional sequence and timing of interventional procedures remain controversial.This review aims to summarize the indications,timing,and treatment outcomes for infected NP and to provide guidance on multidisciplinary decision-making. | Birte Purschke Louisa Bolm Max Nikolaus Meyer Hiroki Sato | 2022 | World Journal of Gastroenterology2022，28，27： | 4 |
| 2 | Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells显示文摘AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth.METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death,flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 (COX-2),p21 and bcl-2 in cells incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 (PGE2) generation in the presence of AA and DHA was measured using a PGE2-ELISA.RESULTS:AA increased cell growth,whereas DHAreduced viability of LS 174T cells in a time-and dose-dependent manner. Furthermore,DHA down-regulated mRNA of bcl-2 and up-regulated p21. Interestingly,DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation,DHA directly reduced PGE2-induced cell proliferation in a dose-dependent manner. CONCLUSION:These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2. | Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang Cheng-Wei He Daniel C Baumgart Jing X Kang | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 3 | IQI-sensitivity and applications of flat-panel detectors and X-ray image intensifiers--a comparison 显示文摘 | Purschke M | 2002 | INSIGHT2002，44，10： | 1 |
| 4 | IQI sensitivity and applications of flatpanel detectors and X-ray image intensifiers-a comparison显示文摘 | Purschke M | 2002 | INSIGHT2002，44，10： | 1 |
| 5 | The 'division of labour' model of eye evolution显示文摘 | Arendt D Hausen H Purschke G | | 0，，： | 1 |
| 6 | SDF-1 inhibition targets the bone marrow niche for cancer therapy 显示文摘 | Roccaro AM Sacco A Purschke WG | 2014 | Cell Rep2014，9，1： | 1 |
| 7 | The Glutamine sythetase from the hyperthermoacidophilic crenarcheon Sulfolobus acidocaldarius:isolation,characterization and sequencing of the gene显示文摘 | Yin Z Purschke WG Schaefer G | 1998 | J Biochem1998，273，3： | 1 |
| 8 | IQI-sensitivity and applications of fiat-panel detectors and X-ray image intensifiers-a comparison显示文摘 | Purschke M | 2002 | INSIGHT2002，44，10： | 1 |
| 9 | Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas) lpr mice显示文摘 | Kulkarni O Pawar RD Purschke W | | 0，，08： | 1 |
| 10 | Biomarkers and Mechanisms of FANCD2 Function显示文摘 | Henning Willers Lisa A. Kachnic Chen-Mei Luo Li Li Martin Purschke Kerstin Borgmann Kathryn D. Held Simon N. Powell Lisa Wiesmuller | 2008 | Journal of Biomedicine and Biotechnology2008，，： | 1 |
| 11 | Ultrastructure of the nuchal organ and cerebral organ in Onchnesoma squamatum (Sipuncula, Phascolionidae)显示文摘 | Purschke G Wolfrath F Westheide W | 1997 | Zoomorphology1997，117，： | 1 |
| 12 | IQI sensitivity and applications of flat-panel detectors and X-ray image intensifiers --A comparison显示文摘 | Purschke M | 2002 | Insight2002，44，10： | 1 |
| 13 | Spiegelmerinhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL- (Fas)lpr mice 显示文摘 | Kulkami O Pawar R D Purschke W | 2007 | J Am Soc Nephrol2007，18，8： | 1 |
| 14 | Spiegelmer inhibition of CCL2IMCP-l ameliorates lupus nephritis in MRL-(Fas)lpr mice显示文摘 | Kulkarni 0 Pawar RD Purschke W | 2007 | J Am Soc Nephrol2007，18，8： | 1 |
| 15 | The glutamine synthetase from the hyperthermoacidophilic crenarcheon Sulfolobus acidocaldarius: isolation, characterization and sequencing of the genes 显示文摘 | Yin Z Purschke WG Schafer G | 1998 | Biol Chem1998，379，11： | 1 |
| 16 | Progenesis in Eunicida (“ Polyehaeta”, Annelida)--separate evolutionary events? Evidence from molecular data 显示文摘 | Struck T H Westheide W Purschke G | 2002 | Molecular Phylogenetics and Evolution2002，25，： | 1 |
| 17 | IQI Sensitivity and Applications of FlatPanel Detectors and X-ray Image Intensifiers-A Comparison显示文摘 | M Purschke | 2002 | INSIGHT2002，44，10： | 1 |
| 18 | Contrasting changes in taxonomic,phylogenetic and functional diversity during a long-term succession:Insights into assembly processes显示文摘 | Purschke O Schmid B C Sykes M T | 2013 | Journal of Ecology2013，101，： | 1 |
| 19 | Ultrastructure of the nuchal organ and cerebral organ in Onchnesoma squamatum(Sipuncula,Phascolionidae)显示文摘 | Purschke G Wolfrath F Westheide W | 1997 | Zoomorphology1997，，117： | 1 |
| 20 | IQI- sensitivity and applications of flatpanel detectors and X-ray image intensifiers-a comparison显示文摘 | Purschke M | 2002 | INSIGHT2002，44，10： | 1 |
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