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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Cytokines and adhesion molecules in the course of acute myocardial infarction显示文摘 | Pudil R Pidrman V Krejsek J | 1999 | Clin Chim Acta1999，280，12： | 1 |
| 3 | Inflammatory response to acute myocardial infarction complicated by cardiogenic shock显示文摘 | Pudil R Krejsek J Pidrman V | 2001 | Acta Medica (Hradec Kralove)2001，44，4： | 1 |
| 4 | Plasma glycogen phosphorylase BB is associated with pulmonary artery wedge pressure and left ventricle mass index in patients with hypertrophic cardiomyopathy显示文摘 | Pudil R Vasatova M Lenco J | 2010 | Clin Chem Lab Med2010，48，8： | 1 |
| 5 | Plas-ma glycogen phosphorylase BB is associated with pul-monary artery wedge pressure and left ventricle mass index in patients with hypertrophic cardiomyopathy显示文摘 | PUDIL R VASATOVA M LENCO J | 2010 | Clin Chem Lab Med2010，48，： | 1 |
| 6 | Cytokines and adhesion molecules in the course of acute myocardial infarction显示文摘 | Pudil R | 1999 | Clin Chim Acta1999，，12： | 1 |
| 7 | Inflammatory response to acute myocardial infarction complicated by cardiogenic shock显示文摘 | Pudil R Krejsek J Pidrman V | 2001 | Acta Medica (Hradec Kralove)2001，，4： | 1 |
| 8 | Biochemical markers and assessment of cardiotoxicity during preparative regimen and hematopoietic cel[transplantation in acute leukenia显示文摘 | Horacek JM Pudil R Tichy M | | 0，，03： | 1 |
| 9 | Re-expression of nestin in the myocandium of postinfarcted patients 显示文摘 | Mokry J Pudil R Ehrmann J | 2008 | Vlnchows Arch2008，453，1： | 1 |
| 10 | Cardiac troponin I seems to be superior to cardiac troponin T in the early detection of cardiac injury associated with anthracycline treatment显示文摘 | HORACEK J M PUDIL R TICHY M | | 0，，10： | 1 |
| 11 | The prognostic significance of intermediate QRS prolongation in acute myocardial infarction显示文摘 | Pudil R Feinberg MS Hod H | 2001 | International Journal of Cardiology2001，78，3： | 1 |
| 12 | Cardiac troponin Ⅰ seems to be superior to cardiac troponin T in the early detection of cardiac injury associated with anthracycline treatment显示文摘 | Horacek JM Pudil R Tichy M | 2008 | Onkologie2008，31，10： | 1 |
| 13 | Biochemical markers and assessment of cardiotoxicity during preparative regimen and hematopoietic cell transplantation in acute leukemia显示文摘 | Horacek JM Pudil R Tichy M | 2007 | Exp Oncol2007，29，3： | 1 |
| 14 | Biochemical markers and assessment of cardiotoxicity during preparative regimen and hematopoietic cell transplantation in acute leukemia显示文摘 | Horacek JM Pudil R Tichy M | 2007 | Exp Oncol2007，29，3： | 1 |
| 15 | Assessment of anthra- cycline - induced cardiotoxicity with biochemical markers 显示文摘 | Horacek JM Pudil R Jebavy I | 2007 | Exp Oncol2007，29，4： | 1 |
| 16 | Cytokines and adhe- siun rnodecules in the reperfused myocardial infarction 显示文摘 | Pudil R Pidrman V Krejsek J | 1999 | Clin Chim Acta1999，280，1： | 1 |
| 17 | Severe bradycardia after a methylprednisolone 'minipulse' treatment显示文摘 | Pudil R Hrncir Z | 2001 | Archives of Internal Medicine2001，161，14： | 1 |
| 18 | Cytokines and adhesion molecules in the course of acute infarction显示文摘 | Pudil R Pidrman V Krejsek J Gregor J Tichy M Andrys C | 1999 | Clin Clim Acta1999，280，12： | 1 |
| 19 | Inflammatory response to acute myocardial infarction complicated by cardiogenic shock 显示文摘 | Pudil R Krejsek J Pidrman V | 2001 | Acta Medica2001，44，4： | 1 |
| 20 | Re-expression of nestin in the myocardium of postinfarcted patients显示文摘 | Mokry J Pudil R Ehrmann J | | 0，，： | 1 |
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