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| 1 | Invasive micropapillary carcinoma:A distinct type of adenocarcinomas in the gastrointestinal tract显示文摘Invasive micropapillary carcinoma(IMPC)is a rare histological type of tumor,first described in invasive ductal breast cancer,than in malignancies in other organs such as lungs,urinary bladder,ovaries or salivary glands.Recent literature data shows that this histological lesion has also been found in cancers of the gastrointestinal system.The micropapillary components are clusters of neoplastic cells that closely adhere to each other and are located in distinct empty spaces.Moreover,clusters of neoplastic cells do not have a fibrousvascular core.The IMPC cells show reverse polarity resulting in typical‘’inside-out’’structures that determines secretary properties,disturbs adhesion and conditions grade of malignancy in gastrointestinal(GI)tract.Invasive micropapillary carcinoma in this location is associated with metastases to local lymph nodes and lymphovascular invasion.IMPC can be a prognostic factor for patients with cancers of the stomach,pancreas and with colorectal cancer since it is related with diseasefree and overall survival.The purpose of this review is to present the characterization of invasive micropapillary carcinoma in colon,rectum,stomach and others site of GI tract,and to determine the immunohistological indentification of IMPC in those localization. | Katarzyna Guzińska-Ustymowicz Katarzyna Niewiarowska Anna Pryczynicz | 2014 | World Journal of Gastroenterology2014，20，16： | 9 |
| 2 | Bax protein may influence the invasion of colorectal cancer显示文摘AIM: To evaluate the expression of Bcl-xL, Bak, and Bax proteins in correlation with particular clinico-histopathological parameters, including tumor invasion front, in patients with colorectal cancer. METHODS: The expression of these proteins was evaluated with the use of the immunohistochemical method in 50 primary tumors. RESULTS: According to observations, a low expression of Bax and Bak proteins is related to the localization of the tumor in the rectum(P < 0.05 and P < 0.05 respectively), which may explain an increased incidence of colorectal cancer in this area. A positive expression of Bax protein also correlates with the presence of cancer cell infiltration to lymph and blood vessels(P < 0.05), which may suggest the participation of this protein in the early stages of colorectal cancer progression. Moreover, a positive expression of Bcl-xL protein correlated with a positive expression of Bak protein. This may suggest a greater participation of Bcl-xL protein in the inhibition of the proapoptotic Bak protein, but not the Bax protein. CONCLUSION: Bax protein is probably very significant in the cancerogenesis mechanism in the large intestine. | Anna Pryczynicz Mariusz Gryko Katarzyna Niewiarowska Dariusz Cepowicz Marek Ustymowicz Andrzej Kemona Katarzyna Guzińska-Ustymowicz | 2014 | World Journal of Gastroenterology2014，20，5： | 3 |
| 3 | Correlation be- tween proliferation markers : PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer 显示文摘 | Guzifiska-Ustymowicz K Pryczynicz A Kemona A | 2009 | Anticancer Res2009，29，8： | 1 |
| 4 | Immunohistochemical evaluation of Ki-67,PCNA and MCM2 proteins proliferation index (PI) in advanced gastric cancer 显示文摘 | Czyzewska J Guzifiska-Ustymowicz K Pryczynicz A | 2009 | Folia Histochem Cytobiol2009，47，2： | 1 |
| 5 | Im- munohistochemical assessment of PRL-3 (PTP4A3) expression in tumor buds, invasion front, central region oftumor and me- tastases of colorectal caneer显示文摘 | Guzinska-Ustymowicz K Pryczynicz A Kemona A | 2011 | Adv Med2011，56，1： | 1 |
| 6 | PRL-3,an Emerging Markerof Carcinogenesis,is Strongly Associated with Poor Prognosis显示文摘 | Guzińska-Ustymowicz K Pryczynicz A | 2011 | An-ticancer Agents Med Chem2011，11，1： | 1 |
| 7 | Expres- sion of the E - cadherin - cateninin patients with pan- creatic ductal adenocarcinoma 显示文摘 | Pryczynicz A Guzinska - Ustymowicz K Kemona A | 2010 | Folia Histochem Cytobiol2010，48，1： | 1 |
| 8 | PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer 显示文摘 | Pryczynicz A Guzihska-Ustymowicz K Niewiarowska K | 2014 | Tumour Biol2014，35，7： | 1 |
| 9 | Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation显示文摘 | Pryczynicz A Guzinska-Ustymowicz K Dymicka-Piekarska V | | 0，，01： | 1 |
| 10 | Immunohistochemical as-sessment of apoptosis-associated proteins:p53,Bcl-Xl显示文摘 | Gryko M Pryczynicz A Guzinska U | 2012 | Adv MedSci2012，22，： | 1 |
| 11 | Correlation between Fas and Fast proteins expression in normal gastric mucosa and gastric cancer显示文摘 | Gryko M Guzinska-Ustymowicz Kv Pryczynicz Av | 2011 | Folia Histochem Cytobiol2011，49，1： | 1 |
| 12 | Correlation between proliferation markers:PCNA Ki-67,MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer显示文摘 | KATARZYNA GU PRYCZYNICZ A ANDRZEJ K | 2009 | Anticancer Res2009，29，8： | 1 |
| 13 | Expression of apoptotic proteins in human colorectal cancer and metastatic lymph nodes显示文摘 | Anna Sadowska Halina Car Anna Pryczynicz Katarzyna Guzińska-Ustymowicz Krzysztof Wojciech Kowal Dariusz Cepowicz Bogus?aw K?dra | 2014 | Pathology - Research and Practice2014，，： | 1 |
| 14 | Immunohistochemical evalualion of Ki-67,PCNA and MCM2 proteins proliferation index(PI)in advanced gastric cancer显示文摘 | Czyzewska J Guzin ska-Ustymowicz K Pryczynicz A | 2009 | Folia Histochem Cytobiol2009，47，2： | 1 |
| 15 | Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation显示文摘 | Pryczynicz A Kemona A Czyzewska J | 2007 | Folia Histochem Cytobiol2007，45，1： | 1 |
| 16 | Expressionofmatrix m etalloproteinase9inpancreaticductalcarcinom aisassociated withtumor metastasisform ation显示文摘 | Pryczynicz A Guzinska-Ustymowicz K Dymicka-PiekarskaV etal | 2007 | FoliaHistochem Cytobiol2007，45，1： | 1 |
| 17 | Immumohistochemical assessment of apoptosis-associated proteins:p53,Bcl-xL,Bax and Bak in gastric cancer cells in correlation with clinical and pathomorphological factors显示文摘 | Gryko M Pryczynicz A Guzinska-Ustymowicz K | 2012 | Adv Med Sci2012，57，： | 1 |
| 18 | Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma显示文摘 | Pryczynicz A Guzinska-Ustymowicz K Kemona A et el | 2010 | Folia Histochem Cytobiol2010，48，1： | 1 |
| 19 | Helicobacter pylori infection and expressions of EGF, EGFR and cerbB-2 proteins in gastric carcinoma显示文摘 | Pryczynicz A Guzinska-Ustymowicz K Kemona A | 2009 | Folia Histochem Cytobiol2009，47，3： | 1 |
| 20 | Immunohisto-chemical assessment of apoptosis-associated proteins:p53,Bcl-xL,Bax and Bak in gastric cancer cells in correlation with clinical and pathomor-phological factors显示文摘 | Gryko M Pryczynicz A Guzińska-Ustymowicz K | 2012 | Adv Med Sci2012，57，1： | 1 |
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