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| 1 | Proteome alterations in aqueous humour of primary open angle glaucoma patients显示文摘AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably altered.RESULTS: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as controls.CONCLUSION: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins. | Hanhan Liu Fabian Anders Sebastian Funke Karl Mercieca Franz Grus Verena Prokosch | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 2 | Ophthalmological symptoms as key findings in neurosyphilis diagnosis and ther- apy显示文摘 | Prokosch V Thanos S Busse H | 2009 | Klin Monatsbl Augenheilkd2009，226，3： | 1 |
| 3 | Perspectives for Medical Informatics Reusing the Electronic Medical Record for Clinical Research显示文摘 | H U Prokosch T Ganslandt | 2009 | Methods InfMed2009，48，1： | 1 |
| 4 | Experiences with an interoperable data acquisition plat(orm fir lnulti-centric research networks based on HL7 CI)A显示文摘 | Klein A Prokosch HLJ Muller M | | Methods lnf Med0，46，3： | 1 |
| 5 | Emerging syphilitic optic neuropa- thy= critical review and recommendations显示文摘 | Prokosch V Thanos S | 2008 | Restor Neurol Neurosei2008，26，45： | 1 |
| 6 | Microbiological find- ings and predisposing risk factors in corneal ulcers显示文摘 | Prokosch V Gatzioufas Z Thanos S | 2012 | Graefes Arch Clin Exp Ophthalmol2012，250，3： | 1 |
| 7 | Ophthalmological symptoms askey findings in neurosyphilis - - diagnosis and therapy 显示文摘 | Prokosch V Thanos S Busse H | 2009 | Klin Mon-bl Augenheilkd2009，226，3： | 1 |
| 8 | Towards smart environments using smart objects显示文摘 | Sedlmayr M Prokosch HU Miinch U | 2011 | StudHealth Technol Inform2011，169，： | 1 |
| 9 | Towards smart environments using smart objects显示文摘 | Sedlmayr M Prokosch H Münch U | | 0，，： | 1 |
| 10 | VEGF, Ang-2 and SR1F associated abnormal postnatal development of the retinal capillary network in the royal college of surgeons rat 显示文摘 | Prokosch V Fink J Heiduschka P | 2011 | Exp Eye Res2011，92，2： | 1 |
| 11 | Ophthalmological symptoms as key findings in neurosyphilis-diagnosis and therapy 显示文摘 | Prokosch V Thanos S Busse H | 2009 | Klin Monatsbl Augenheilkd2009，226，3： | 1 |
| 12 | VEGF,Ang - 2 and SRIF associated abnormal postnatal development of the retinal capillary net- work in the Royal College of Surgeons rat显示文摘 | Prokosch V Fink J Heiduschka P | 2011 | Exp Eye Res2011，92，： | 1 |
| 13 | Emerging syphilitic optic neuropathy:critical review and recommendations 显示文摘 | Prokosch V Thanos S | 2008 | Restor Neurol Neurosci2008，26，45： | 1 |
| 14 | Electronic Discharge Letters Using the Clinical Document Architecure(CDA) 显示文摘 | Muller ML Butta R Prokosch HU | 2003 | Stud Health Technol Inf2003，，95： | 1 |
| 15 | Community Health Ii~forlllatioll Networks:Steps Towards all Elctronic Patient Record显示文摘 | Prokosch HU | 2000 | Word Congress of High-tenh Medicine2000，，12： | 1 |
| 16 | 原住民与生物多样性显示文摘"我今天之所以成为一名因纽特人,全因祖先之故。在这严酷的冰天雪地里,他们苦苦求索生存之道,最终全依靠鲸鱼等大自然的生灵活下来。当我外出捕捉鲸鱼的时候,脑海里一下子涌现出许多东西,它们不属于现在,而是存在于过去,存在于我的祖先一路走来的那个时代。是的,在我捕捉鲸鱼的时候,昔日父辈的教诲总是萦绕耳畔。"北极原住民自述。 | Tero Mustonen Violet Ford Peter Prokosch 先义杰 | 2016 | 人与生物圈2016，0，1： | 0 |
| 17 | 新一族基于CPLD软核的微控制器显示文摘 | Steve Prokosch | 2003 | 电子产品世界2003，10，06A： | 0 |
| 18 | FPGA硬件与IP组成的低成本显示器解决方案显示文摘 | Steve Prokosch Josephine Sy | 2006 | 今日电子2006，，4： | 0 |
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