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| 1 | Dendritic macromolecules as nano-scale drug carriers:Phase solubility,in vitro drug release,hemolysis and cytotoxicity study显示文摘Potential of nanoscale triazine based dendritic macromolecules G1,G2 and G3 as solubility enhancers of drug was investigated.Effect of pH,concentration and generation of synthesized dendritic macromolecules on solubility of ketoprofen was studied.G3 dendrimer was further exploited as carrier for sustained release.Ketoprofen was encapsulated by inclusion complex method and also characterized by Flourier Transform Infrared spectroscopy.Sustained release study of ketoprofen from ketoprofen loaded dendrimer was carried out and compared with free ketoprofen.Hemolytic potential and Cytotoxicity assay using A-549 lung cancer cell lines revealed that synthesized triazine based dendritic macromolecules having more potential that commercially available PAMAM dendrimer. | Pravinkumar M.Patel Rinkesh Patel Devang Wadia Rajni M.Patel | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，4： | 3 |
| 2 | An efficient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives显示文摘A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction of acetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyl derivatives 3a–3c in the presence of potassium carbonate afforded the target compounds, namely ethyl2-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-2-oxoacetate derivatives 4a–4e, ethyl 3-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-3-oxopropanoate derivatives 4f–4i, di((4-acetyl-3-methyl-5-phenylamino)thiophen-2-yl)ketone derivatives 4j–4n in reasonable overall yields. The synthesized compounds were screened for antimicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported. | Pravinkumar N.Sable Swastika Ganguly Pravin D.Chaudhari | 2014 | Chinese Chemical Letters2014，25，7： | 1 |
| 3 | Noninvasive mechanical ventilation in high-risk pulmonary infections: a clinical review显示文摘 | Esquinas AM Egbert Pravinkumar S Scala R | 2014 | Eur Respir Rev2014，23，134： | 1 |
| 4 | Sacrococcygeal neurofibroma:rare cause for chronic pelvic pain显示文摘 | Paul P Pravinkumar T Sheetal B | 2012 | J Minim Invasive Gynecol2012，19，4： | 1 |
| 5 | Noninvasive mechanical ventilation in high-risk pulmonary infections:a clinical review显示文摘 | Esquinas AM Egbert Pravinkumar S Scala R | 2014 | Eur Respir Rev2014，23，134： | 1 |
| 6 | Mechanical insufflation-exsufflationin prevention of post-extubation acute respiratory failure: most wel-come but must be used cautiously in critically ill patients 显示文摘 | Esquinas RA Pravinkumar E | 2012 | Criti-cal Care2012，16，3： | 1 |
| 7 | 柚苷配基对慢性压迫性损伤引起的大鼠触摸痛及痛觉过敏的影响(英文)显示文摘目的:研究柚苷配基对慢性压迫性神经损伤模型的镇痛效果。方法:经慢性压迫性损伤建立神经性疼痛大鼠模型后,分别给予模型大鼠25和50mg/kg的柚苷配基以及10mg/kg的普加巴林。在第0、3、5、7、14和21天采用Hargreaves方法评估大鼠的行为变化,针刺实验测试触觉性机械痛觉过敏和经冷水诱发的异常性疼痛,最后测定氧化应激反应参数。结果:柚苷配基能缓解经慢性压迫性损伤诱发的神经性疼痛,减轻脂质过氧化反应,降低一氧化氮水平,恢复还原型谷胱甘肽含量。结论:柚苷配基能缓解坐骨神经损伤引起的疼痛。 | Shyam Kaulaskar Pravinkumar Bhutada Anand Rahigude Dilpesh Jain Uday Harle | 2012 | 中西医结合学报2012，10，12： | 1 |
| 8 | Kaposi’s Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats显示文摘 | Pravinkumar Purushothaman Maria E. McDowell James McGuinness Ruth Salas Sharif M. Rumjahn Subhash C. Verma | 2012 | Journal of Virology2012，，18： | 1 |
| 9 | HIT/HITT and alternative anticoagulation显示文摘 | Webster NR | 2003 | Current Concepts Br J Anaesth2003，90，5： | 1 |
| 10 | Surgical obturator duplicating original tissue-form restores esthetics and function in oral cancer显示文摘Oral cancer treatment primarily focused on the surgical removal of cancer tissues followed by surgical/prosthetic reconstruction.Restoration of the missing structures immediately after surgery shortens recovery time and allows patient to return to community as a functioning member.The most practiced surgical obturators are simple resin prosthetic bases without incorporation of the teeth.This article highlights a technique to fabricate a surgical obturator that duplicates patient’s original tissue form including teeth,alveolus and palatal tissues.The obturator is placed immediately after surgery and make patient feel unaware of surgical deformity.The obturator prosthesis fabricated with this technique supports soft tissues and minimizes the scar contracture.We have clinically tried this technique in 11 patients.Patients’satisfaction level was recorded on visual analogue scale(VAS)and it ranges between 74%and 94%(with average of 87%).Four different prosthodontists have visually evaluated facial asymmetry of patients at6 mo recall and their average perception on VAS varies between 71%and 93%(with average of 84%). | Pravinkumar G Patil | 2013 | World Journal of Stomatology2013，2，4： | 0 |
| 11 | ZnO-beta zeolite:As an effective and eco-friendly heterogeneous catalyst for the synthesis of benzothiazole derivatives显示文摘A cheap and recyclable ZnO-beta zeolite was used as catalyst for the synthesis of benzothiazole derivatives.This method provides several advantages such as environmental friendliness,short reaction times,high yields,simple work-up procedure and catalyst was successfully reused for four cycles without significant loss of activity. | Santosh S.Katkar Pravinkumar H.Mohite Lakshman S.Gadekar Kaluram N.Vidhate Machhindra K.Lande | 2010 | Chinese Chemical Letters2010，21，4： | 0 |
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