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| 1 | Management of splenic artery aneurysm associated with extrahepatic portal vein obstruction显示文摘BACKGROUND: Splenic artery aneurysms although rare are clinically significant in view of their propensity for spontaneous rupture and life-threatening bleeding. While portal hypertension is an important etiological factor, the majority of reported cases are secondary to cirrhosis of the liver. We report three cases of splenic artery aneurysms associated with extrahepatic portal vein obstruction and discuss their management. METHODS: The records of three patients of splenic artery aneurysm associated with extrahepatic portal vein obstruction managed from 2003 to 2010 were reviewed retrospectively. The clinical presentation, surgical treatment and outcome were analyzed. RESULTS: The aneurysm was >3 cm in all patients. The clinical symptoms were secondary to extrahepatic portal vein obstruction (hematemesis in two, portal biliopathy in two) while the aneurysm was asymptomatic. Doppler ultrasound demonstrated aneurysms in all patients. A proximal splenorenal shunt was performed in two patients with excision of the aneurysm in one patient and ligation of the aneurysm in another one. The third patient had the splenic vein replaced by collaterals and hence underwent splenectomy with aneurysmectomy. All patients had an uneventful post-operative course. CONCLUSIONS: Splenic artery aneurysms are associated with extrahepatic portal vein obstruction. Surgery is the mainstay of treatment. Although technically difficult, it can be safely performed in an experienced center with minimal morbidity and good outcome. | Pramod Kumar Mishra Sundeep Singh Saluja Ashok K Sharma Premanand Pattnaik | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 4 |
| 2 | Effect of Semecarpus anacardium fruits on reproductive function of male albino rats显示文摘Aim: To evaluate the effect of an ethanolic extract of Semecarpus anacardium fruits on spermatogenesis in albino rats. Methods: Male albino rats were fed with a 50 % ethanolic extract of Semecarpus anacardium fruit at 100 mg·kg^-l·day^-1, 200 mg·kg^-l·day^-1 and 300 mg·kg^-1·day^-1 for 60 days. Fertility test was performed after 60 days of treatment. Sperm motility and density were observed in the cauda epididymis. Biochemical and histological analyses of the blood and reproductive organs were done. Recovery of fertility was followed to evaluate the reversibility of drug action. Results: S. anacardium fruit extract administration resulted in spermatogenic arrest in albino rats. Thes perm motility and density was reduced significantly. The RBC and WBC counts, haemoglobin, haematocrit, blood sugar and urea were found to be within the normal range in the whole blood. The protein, cholesterol and glycogen in the testes and the fructose in the seminal vesicle were significantly decreased after the treatment. The fruit extract feeding caused marked reduction in the number of primary spermatocytes, secondary spermatocytes and spermatids.The number of mature Leydig cells was also decreased and degenerating cells increased proportionately. Conclusion:S. anacardium fruit extract causes spermatogenic arrest in albino rats. ( Asian J Androl 2003 Jun; 5: 121-124) | Arti Sharma Pramod Kumar Verma V.P.Dixit | 2003 | Asian Journal of Andrology2003，5，2： | 3 |
| 3 | Predicting suitability of different scale-dependent dispersivities for reactive solute transport through stratified porous media显示文摘In this paper,the behavior of breakthrough curves(BTCs) for reactive solute transport through stratified porous media is investigated.A physical laboratory model for layered porous media was constructed,in which thin layer of gravel was sandwiched in between two thick layers of natural soil.Gravel layer and natural soil layers were hydraulically connected as single porous continuum.A constant source of tracer was connected through gravel layer and elucidated at different sampling points in the direction of flow.Flexible multiprocess non-equilibrium(MPNE) transport equation with scale-dependent dispersivity function was used to simulate experimental BTCs of reactive solute transport through layered porous media.The values of equilibrium sorption coefficient and other input parameters were obtained experimentally.The simulation of BTC was performed using MPNE model with scale-dependent dispersivity.The simulation of different scale-dependent dispersivities was then compared and it was found that for field scale of estimation of dispersivity,asymptotic and exponential dispersivity functions performed better.In continuation to the comparison of simulated BTCs obtained using different models,spatial moment analysis of each aforesaid scale-dependent dispersivity model was also done.Spatial moment analysis provides the information related to mean solute mass,rate of mass travel,and mean plume dispersion.Linear and constant dispersivities showed higher variance as compared to asymptotic and exponential dispersion functions.This supports the field applicability of asymptotic and exponential dispersivity functions.The BTCs were also found to elucidate a nonzero concentration with time,which was clearly affected by physical non-equilibrium.In natural condition,such information is required in effective aquifer remediation process. | Deepak Swami Abhimanyu Sharma Pramod Kumar Sharma Dericks P.Shukla | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，6： | 2 |
| 4 | Primary pediatric mid-brain lymphoma:Report of a rare pediatric tumor in a rare location显示文摘Primary central nervous system lymphoma(PCNSL) is a rare disease in pediatric age group. A thirteen-yearold male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients. | Rony Benson Supriya Mallick Suvendu Purkait Vaishali Suri K P Haresh Subhash Gupta Dayanand Sharma Pramod Kumar Julka Goura Kishore Rath | 2016 | World Journal of Clinical Cases2016，4，12： | 2 |
| 5 | Microwave as- sisted synthesis of novel pyrimidine derivatives and inves- tigation of their analgesic and ulcerogenic activity显示文摘 | Anshu Chaudhary Pramod Kumar Sharma | 2012 | Me- dicinal Chemisty Research2012，21，： | 1 |
| 6 | Design of Combretastatin A-4 Analogs as Tubulin Targeted Vascular Disrupting Agent with Special Emphasis on Their Cis-Restricted Isomers显示文摘 | Harish Rajak Pramod Kumar Dewangan Vijay Patel Deepak Kumar Jain Avineesh Singh Ravichandran Veerasamy Prabodh Chander Sharma Anshuman Dixit | 2013 | Current Pharmaceutical Design2013，，10： | 1 |
| 7 | MOLECULAR DYNAMICS SIMULATION OF POLYMER/CARBON NANOTUBE COMPOSITES显示文摘In this paper, we present classical molecular dynamics(MD) simulations of model polymer/CNT composites constructed by embedding a single wall(10,10) CNT into two different amorphous polymer matrices: poly(methyl methacrylate) and poly{(m-phenylene-vinylene)-co-[(2,5-dioctoxy-p-phenylene) vinylene]}, respectively, with different volume fractions. The simulation results support the idea that it is possible to use CNTs to mechanically reinforce an appropriate polymer matrix, especially in the longitudinal direction of the nanotube. The comparison of the simulation results with the macroscopic rule-of-mixtures for composite systems showed that for strong interfacial interactions, there can be large deviations of the results from the rule-ofmixtures. In order to verify this study, results obtained have been compared with those given by Elliott and Han(2007). | Sumit Sharma Rakesh Chandra Pramod Kumar Navin Kumar | 2015 | Acta Mechanica Solida Sinica2015，28，4： | 1 |
| 8 | Intracranial meningeal hemangiopericytoma: 10?years experience of a tertiary care Institute显示文摘 | Narendra Kumar Ritesh Kumar Rakesh Kapoor Sushmita Ghoshal Pramod Kumar Pravin Salunke B. Radotra Suresh Sharma | 2012 | Acta Neurochirurgica2012，，9： | 1 |
| 9 | Snowfall Shift and Precipitation Variability over Sikkim Himalaya Attributed to Elevation-Dependent Warming显示文摘Sikkim Himalaya hosts critical water resources such as glacial,rain,and snow-fed springs and lakes.Climate change is adversely affecting these resources in various ways,and elevation-dependent warming is prominent among them.This study is a discussion of the elevation-dependent warming(EDW),snowfall shift,and precipitation variability over Sikkim Himalaya using a high-resolution ERA5-land dataset.Furthermore,the findings show that the Sikkim Himalaya region is experiencing a warming trend from south to north.The majority of the Sikkim Himalayan region shows a declining trend in snowfall.A positive advancement in snowfall trend(at a rate of 1 mm per decade)has been noticed above 4500 meters.The S/P ratio indicates a shift in snowfall patterns,moving from lower elevations to much higher regions.This suggests that snowfall has also transitioned from Lachung and Lachen(3600 m)to higher elevated areas.Moreover,the seasonal shifting of snowfall in the recent decade is seen from January-March(JFM)to February-April(FMA).Subsequently,the preceding 21 years are being marked by a significant spatiotemporal change in temperature,precipitation,and snowfall.The potent negative correlation coefficient between temperature and snowfall(–0.9),temperature and S/P ratio(–0.5)suggested the changing nature of snowfall from solid to liquid,which further resulted in increased lower elevation precipitation.The entire Sikkim region is transitioning from a cold-dry to a warm-wet weather pattern.In the climate change scenario,a drop in the S/P ratio with altitude will continue to explain the rise in temperature over mountainous regions. | Pramod Kumar Khushboo Sharma | 2023 | Journal of Atmospheric Science Research2023，6，4： | 0 |
| 10 | Favipiravir-induced Liver Injury in Patients with Coronavirus Disease 2019显示文摘Favipiravir,an antiviral,was given restricted emergency use approval to treat coronavirus disease 2019(COVID-19)in many countries.While the clinical efficacy of favipiravir in COVID-19 remains uncertain,the approval was based on findings from in vitro studies and a clinical trial.1 Limited data from studies of the Ebola virus and influenza disease showed a favorable safety profile.2 Herein,we provide the first report of drug-induced liver injury(DILI)due to favipiravir in patients treated for COVID-19. | Pramod Kumar Anand Kulkarni Mithun Sharma Padaki Nagaraja Rao Duvvuru Nageshwar Reddy | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 0 |
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