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| 1 | Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials显示文摘Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets. | Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 3 | Hepatitis C virus and non-Hodgkin's lymphomas:Metaanalysisof epidemiology data and therapy options显示文摘Hepatitis C virus(HCV) is a global health problem affecting a large fraction of the world's population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell 'benign' lymphoproliferative disorders, represents the most closely related as well as the most investigated HCVrelated extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin's lymphoma(NHL)] as well as hepatic malignancies(hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL's lymphoma. Furthermore, the possibility to treat these HCV-related NHL with the antiviral therapy or with other therapeutic options, like chemotherapy, is also discussed. | Gabriele Pozzato Cesare Mazzaro Luigino Dal Maso Endri Mauro Francesca Zorat Giulia Moratelli PietroBulian Diego Serraino Valter Gattei | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 4 | Different genotypes of hepatitis C virus areassociated with different severity of chronic liver disease显示文摘 | Pozzato G Kaneko S Moretti M | 1994 | J Med Virol1994，43，3： | 1 |
| 5 | Intermittent exposure to social defeat and open-field test in rats:acute and long-term effects on EGG,body temperature and physical activity显示文摘 | Pozzato C Meerlo P | 2002 | Stress2002，5，1： | 1 |
| 6 | High blood alcohollevels in women, the role of decreased gastric alcohol dehydrogenase activity andfirst-pass metabolism显示文摘 | Frezza M DiPadova C Pozzato G Terpin M Baraona E Lieber CS | 1990 | New Eng J Med1990，322，： | 1 |
| 7 | Superhydrophobic Surfaces Fabricated by Nanoimprint Lithography显示文摘 | A Pozzato S Dal Zilio G Fois | 2006 | Microelectronic Engineering2006，83，： | 1 |
| 8 | Thalidomide therapy in compensated and decompensated myelofibrosis with myeloid metaplasia显示文摘 | Pozzato G Zorat F Nascimber F | 2001 | Haematologica2001，86，6： | 1 |
| 9 | Rantidine bismuth citrate plus clarithromycin 7-day regimen is effective in eradicating helicobacter pyloriin patients with duodenal ulcer 显示文摘 | Zagari M Cardelli A | 1998 | Aliment pharmacol Ther1998，12，5： | 1 |
| 10 | Helicobacter pylori and functional dyspepsia: review of previous studies and commentary on new data显示文摘 | Bazzoli F Luca DL Pozzato P | 2002 | Gut2002，50，4： | 1 |
| 11 | Somatic mutation,clonal diversity, and preferential expression of the VH51pl/Vlkv325 immunocytomas显示文摘 | Ivnovski M Silversti F Pozzato G | 1998 | Blood1998，91，： | 1 |
| 12 | Evaluation of short-term lowdose triple therapy for the eradication of Helicobacter pylori by factorial design in a randomized,double-blind,controlled study显示文摘 | Bazzoli F Zagari M Pozzato P | 1998 | Aliment Pharmacol Ther1998，12，5： | 1 |
| 13 | Full-length genomic sequence of a hepatitis C virus genotype 2c isolate (BEBE1) and the 2c-specific PCR primers显示文摘 | H. Nakao H. Okamoto H. Tokita T. Inoue H. Iizuka G. Pozzato S. Mishiro | 1996 | Archives of Virology (-)1996，，3： | 1 |
| 14 | Effects of E2F1–cyclin E1–E2 circuit down regulation in hepatocellular carcinoma cells显示文摘 | Rossella Farra Barbara Dapas Gabriele Pozzato Bruna Scaggiante Francesco Agostini Cristina Zennaro Mario Grassi Natalia Rosso Carlo Giansante Nicola Fiotti Gabriele Grassi | 2011 | Digestive and Liver Disease2011，，12： | 1 |
| 15 | Intermittent exposure to social defeat and open-field test in rats: acute and long-term effects on EGG, body temperature and physical activity 显示文摘 | Sgoifo A Pozzato C Meerlo P | 2002 | Stress2002，5，1： | 1 |
| 16 | Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels显示文摘 | Daniele Baiz Gabriele Pozzato Barbara Dapas Rossella Farra Bruna Scaggiante Mario Grassi Laura Uxa Carlo Giansante Cristina Zennaro Gianfranco Guarnieri Gabriele Grassi | 2008 | Biochimie2008，，3： | 1 |
| 17 | Is there a role for FDG PET in the diagnosis of musculoskeletal neoplasms ?显示文摘 | Messa C Landoni C Pozzato C | 2000 | J Nucl Med2000，41，： | 1 |
| 18 | Proteomic analysis of rat hippocampus after repeated psychosocial stress显示文摘 | Carboni L Piubelli C Pozzato C | | 0，，04： | 1 |
| 19 | Superhydrophobic surfaces fabricated by nanoimprint lithography 显示文摘 | Pozzato A Zilio S D Fois G | 2006 | Microelectronic Engineering2006，83，49： | 1 |
| 20 | Serum response factor depletion affects the proliferation of the hepatocellular car- cinoma cells HepG2 and JHH6显示文摘 | Farra R Dapas B Pozzato G | 2010 | Biochimie2010，92，5： | 1 |
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