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| 1 | Propofol vs midazolam sedation for elective endoscopy in patients with cirrhosis:A systematic review and meta-analysis of randomized controlled trials显示文摘BACKGROUND Patients with cirrhosis frequently require sedation for elective endoscopic procedures.Several sedation protocols are available,but choosing an appropriate sedative in patients with cirrhosis is challenging.AIM To conduct a systematic review and meta-analysis to compare propofol and midazolam for sedation in patients with cirrhosis during elective endoscopic procedures in an attempt to understand the best approach.METHODS This systematic review and meta-analysis was conducted using the PRISMA guidelines.Electronic searches were performed using MEDLINE,EMBASE,Central Cochrane,LILACS databases.Only randomized control trials(RCTs)were included.The outcomes studied were procedure time,recovery time,discharge time,and adverse events(bradycardia,hypotension,and hypoxemia).The risk of bias assessment was performed using the Revised Cochrane Risk-of-Bias tool for randomized trials(RoB-2).Quality of evidence was evaluated by GRADEpro.The meta-analysis was performed using Review Manager.RESULTS The search yielded 3,576 records.Out of these,8 RCTs with a total of 596 patients(302 in the propofol group and 294 in the midazolam group)were included for the final analysis.Procedure time was similar between midazolam and propofol groups(MD:0.25,95%CI:-0.64 to 1.13,P=0.59).Recovery time(MD:-8.19,95%CI:-10.59 to-5.79,P<0.00001).and discharge time were significantly less in the propofol group(MD:-12.98,95%CI:-18.46 to-7.50,P<0.00001).Adverse events were similar in both groups(RD:0.02,95%CI:0-0.04,P=0.58).Moreover,no significant difference was found for bradycardia(RD:0.03,95%CI:-0.01 to 0.07,P=0.16),hypotension(RD:0.03,95%CI:-0.01 to 0.07,P=0.17),and hypoxemia(RD:0.00,95%CI:-0.04 to 0.04,P=0.93).Five studies had low risk of bias,two demonstrated some concerns,and one presented high risk.The quality of the evidence was very low for procedure time,recovery time,and adverse events;while low for discharge time.CONCLUSION This systematic review and meta-analysis based on RCTs show that propofol has shorter recovery and patient discharge time as compared to midazolam with a similar rate of adverse events.These results suggest that propofol should be the preferred agent for sedation in patients with cirrhosis. | John Alexander Lata Guacho Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Alberto Machado da Ponte Neto Shailendra Singh Marina Gammaro Baldavira Tucci Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，8： | 4 |
| 2 | Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review显示文摘Oxidative stress,inflammation,and gut microbiota impairments have been implicated in the development and maintenance of diabetes mellitus.Strategies capable of recovering the community of commensal gut microbiota and controlling diabetes mellitus have increased in recent years.Some lactobacilli strains have an antioxidant and anti-inflammatory system capable of protecting against oxidative stress,inflammation,and diabetes mellitus.Experimental studies and some clinical trials have demonstrated that Limosilactobacillus fermentum strains can beneficially modulate the host antioxidant and anti-inflammatory system,resulting in the amelioration of glucose homeostasis in diabetic conditions.This review presents and discusses the currently available studies on the identification of Limosilactobacillus fermentum strains with anti-diabetic properties,their sources,range of dosage,and the intervention time in experiments with animals and clinical trials.This review strives to serve as a relevant and well-cataloged reference of Limosilactobacillus fermentum strains capable of inducing anti-diabetic effects and promoting health benefits. | Diego Cabral Lacerda Paulo César Trindade da Costa Paula Brielle Pontes Lucas Alves Carneiro dos Santos JoséPatrocínio Ribeiro Cruz Neto Cristiane Cosmo Silva Luis Vanessa Polyana de Sousa Brito JoséLuiz de Brito Alves | 2022 | World Journal of Diabetes2022，13，9： | 3 |
| 3 | Unified Method for the Prediction of Rain Attenuation in Satellite and Terrestrial Links显示文摘 | DA SILVA MELLO L PONTES M S | 2012 | Journal of Microwaves Optoelectronics and Electromagnetic Applications2012，11，1： | 1 |
| 4 | Prediction of rain attenuation in terrestrial links using full rainfall rate distribution显示文摘 | SILLVA MELLO DA L A R PONTES M S SOUZA DE R M | 2007 | Electronics Letters2007，43，25： | 1 |
| 5 | Storage temperature effect on histamine formation in big eye tuna and skipjack显示文摘 | SILVA C C G da PONTE D J B DAPKEVICIUS M L N | 1998 | Journal of Food Science1998，63，4： | 1 |
| 6 | Clinical and radiographic changes around dental implants inserted in different levels in relation to the crestal bone,under different restoration protocols,in the dog model显示文摘 | Pontes AE Ribeiro FS da Silva VC | 2008 | J Periodontol2008，79，3： | 1 |
| 7 | Supercritical fluid extraction of tobacco leaves:A preliminary study on the extraction of solanesol显示文摘 | Alejandro Ruiz-Rodriguez Maria-Ros′ario Bronze Manuel Nunes da Ponte | | 0，，： | 1 |
| 8 | Lipase catalyzed esterifi-cation of glycidol in organic solvents显示文摘 | Martin J F Da Ponte M N Barreiros S | 1993 | Biotechnol Bioeng1993，42，： | 1 |
| 9 | A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of brazil (Sao Goncalo do amaranto, RN)显示文摘 | da Silva VO Borja-Cabrera GP Correia Pontes NN | 2000 | Vaccine2000，19，910： | 1 |
| 10 | Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice显示文摘目的: Aripiprazole 是一个抑制精神的代理人对待精神分裂症,它通过多巴胺 D 2 扮演部分 agonism,血清素 5-HT 1A 部分 agonism 和 5-HT 2A 对抗。这研究被设计在 lipoperoxidation 上评估 neurobehavioral 效果和代理人,以及它的效果的 genotoxic/mutagenic 活动。 | Jaqueline Nascimento PICADA Bruna de Jesus Neto DOS SANTOS Franciele CELSO Jessica Dias MONTEIRO Kelly Morais DA ROSA Leandro Rosa CAMACHO Luciana Rodrigues VIEIRA Tars Madelon FREITAS Tatiana Grasiela DA SILVA Viviane Minuzzo PONTES Patricia PEREIRA | 2011 | Acta Pharmacologica Sinica2011，32，10： | 1 |
| 11 | Hyponatremia in acute-phase response syndrome patients in general surgical wards显示文摘 | Ferreira Da Cunha D Pontes Monteiro J Modesto Dos Santos V | 2000 | Am J Nephrol2000，20，1： | 1 |
| 12 | Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats显示文摘 | de Oliveira MS da Silva Fernandes MJ Scorza FA Persike DS Scorza CA da Ponte JB | 2010 | Brain Res Bull2010，83，5： | 1 |
| 13 | Leaf traits affect the above-ground productivity and quality of pasture grasses显示文摘 | Pontes L DA S Soussana J-F Louauh F | 2007 | Functional Ecology2007，21，： | 1 |
| 14 | Habitat filtering and niche differentiation jointly explain species relative abundance within grassland communities along fertility and disturbance gradients显示文摘 | Maire V Gross N B6rger L Proulx R Wirth C da Silveira Pontes L Soussana J F Louault F | 2012 | New Phytologist2012，196，： | 1 |
| 15 | Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression:Miami experience显示文摘 | Froud T Ricord C Baidal DA Hafiz MM Ponte G Cure P | | 0，，： | 1 |
| 16 | Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil显示文摘AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible gaps.METHODS A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as 'low'(0-28 correct answers) or 'desirable'(29-46 correct answers). Associations between sociodemographic characteristics and perception were also evaluated.RESULTS A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas. | Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos Jurema Corrêa da Mota Filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar | 2018 | World Journal of Hepatology2018，10，11： | 1 |
| 17 | Historical changes in the structure and functioning of the benthic community in the lagoon of Venice显示文摘 | Pranovi F Da Ponte F Torricelli P | | 0，，4： | 1 |
| 18 | Influence of testosterone therapy on clinical and immunologic features of autoimmune disease associated with Klinefelter's syndrome显示文摘 | Bizzarro A Valentini G Dimartino G Da Ponte A De Bellis A Iacono G | 1987 | J Clin Endocrinol Metab1987，64，1： | 1 |
| 19 | Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (Sao Gon c alo do Amarante, RN) 显示文摘 | Borja-Cabrera GP Correia Pontes NN da Silva VO | 2002 | Vaccine2002，20，2728： | 1 |
| 20 | Leaf traits affect the above-ground productivity and quality of pasture grasses显示文摘 | Pontes L DA S Soussana J F Louault F | 2007 | Functional Ecology2007，21，： | 1 |
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