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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Matemal-conceptus cross talk-a review 显示文摘 | Vigano P Mangioni S Pompei F | 2003 | Placenta2003，24，： | 1 |
| 3 | A new method ofclassifying prognostic comorbidity in longitudinal studies : developmentand validation 显示文摘 | Charlson ME Pompei P Ales KL | 1987 | Journal of Chronic Diseases1987，40，5： | 1 |
| 4 | In situ hybridization analysis of preprotachykinin-A mRNA levels in young and old rats显示文摘 | Pompei P Severini R Costa G | 1999 | Mol Brain Res1999，64，： | 1 |
| 5 | A new method ofclassify prognostic comorbidity in longitudinal studies: de-velopment and validation 显示文摘 | Charlson M E Pompei P Ales K L | 1987 | Journal of Chronic Disease1987，40，5： | 1 |
| 6 | A new method of classifyingprognostic comorbidity in longitudinal studies: development and validation 显示文摘 | CHARLSON ME POMPEI P ALES KL | 1987 | J Chronic Dis1987，40，5： | 1 |
| 7 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation 显示文摘 | Charlson ME Pompei P Ales KL | 1987 | J Chronic Dis1987，40，： | 1 |
| 8 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation显示文摘 | CHARLSON M E POMPEI P ALES K L | 1987 | J Chronic Dis1987，40，5： | 1 |
| 9 | In situ hybridization analysis of preprotachykinin -A and B-mRNA levels in short -term sodium depletion显示文摘 | Pompei P Lucas LR Angeletti S | 1997 | Brain Res Mol Brain Res1997，49，12： | 1 |
| 10 | A new method of clas- sifying prognostic eomorbidity in longitudinal studies: develop- ment and validation 显示文摘 | Charlson ME Pompei P Ales KL | 1987 | J Chronie Dis1987，40，5： | 1 |
| 11 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation显示文摘 | Charlson ME Pompei P Ales KL | 1987 | J Chronic Dis1987，40，5： | 1 |
| 12 | A new method ofclassifying prognostic comorbidity in longitudinal studies :development and validation 显示文摘 | Charlson ME Pompei P Ales KL | 1987 | J Chronic Dis1987，40，5： | 1 |
| 13 | Delirium in hospitalized older persons:outcomes and predictors显示文摘 | Pompei P Foreman M Rudberg M A | 1994 | J Am Geriatr Soc1994，42，8： | 1 |
| 14 | A newmethod of classif- ying prognostic comorbidity in longitudinal studies: development and validation显示文摘 | Charlson ME Pompei P Ales KL | 1987 | J Chron Dis1987，40，： | 1 |
| 15 | A new method of clas- sifying prognostic comorbidity in longitudinal studies: develop- ment and validation 显示文摘 | Charlson ME Pompei P Ales KL | 1987 | J Chronic Dis1987，40，5： | 1 |
| 16 | A new method of classifying prognostic comorbidity in longitudinal studies: de?velopment and validation显示文摘 | Charlson ME Pompei P Ales KL et sl | 1987 | J Chronic Dis1987，40，5： | 1 |
| 17 | A new method of classifying prognostic comorbidi ty in longi tudinal studies: development and validation显示文摘 | Charlson ME Pompei P Ales KL | 1987 | J Chronic Dis1987，40，： | 1 |
| 18 | Delirium in hospitalized older persons:outcomes and predictors显示文摘 | Pompei P Foreman M Rudberg MA | 1994 | J Am Geriatr Soc1994，42，8： | 1 |
| 19 | Delirium in hospitalized older persons: outcomes and predictors显示文摘 | Pompei P Foreman M Rudberg MA | 1994 | J Am Geriatr Soc1994，42，8： | 1 |
| 20 | Delirium in hospitalized older persons:outcomes and predictors显示文摘 | Pompei P Foreman M Rudberg M A | 1994 | J Am Geriatr Soe1994，42，8： | 1 |
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