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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor κB activation in mouse colonocytes显示文摘 | Kaiser CG Yan F Polk B | | 0，，： | 1 |
| 3 | Probiotics and immune health显示文摘 | Fang Y N Polk D B | 2011 | Wolters Kluwer Health2011，，27： | 1 |
| 4 | Probiotics as functional food in the treatment of diarrhea显示文摘 | Yan F Polk D B | 2006 | Curr Opin Clin Nutr Metab Care2006，9，6： | 1 |
| 5 | Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells显示文摘 | Yan F Polk B | 2002 | J Bio Chem2002，277，50： | 1 |
| 6 | Folic acid pathway single nucleotide polymorphisms associated with methotrexate significantadverse events in United States veterans with rheumatoid arthritis 显示文摘 | Davis LA Polk B Mann A | 2014 | Clin Exp Rheumatol2014，32，3： | 1 |
| 7 | ISE analysis of hydrogen sulfide in cigarette smoke显示文摘 | Li G Polk B J Meazell L A | 2000 | Journal of Chemical Education2000，77，08： | 1 |
| 8 | Risk factors for nosocomial urinary tract infection显示文摘 | Platt R Polk BF Murdock B | 1986 | Am J Epidemiol1986，124，6： | 1 |
| 9 | Refractory amorphous inter-transition metal alloys显示文摘 | GIESSEN B C MAHAVA M POLK D E VANDER SANDE J | 1976 | Materials Science and Engineering1976，23，： | 1 |
| 10 | Synthesis and characterization of 3,6-bis ( 1 H-1, 2,3,4-tetrazol-5 -yl-amino ) -1, 2,4,5- tetrazine (BTATz) : Novel high-nitrogen content insensitive high energy material显示文摘 | Saikia A Sivabalan R Polke B G | 2009 | Journal of Hazardous Materials2009，170，： | 1 |
| 11 | Risk factors for nosocomial urinary tract infection显示文摘 | Platt R Polk BF Murdock B Rosner B | 1986 | Am J Epidemiol1986，124，6： | 1 |
| 12 | Synthesis and characterization of bis-azido methyl oxetane and its polymer and copolymer with tetrahydrofuran显示文摘 | Nair J K Satpute R S Polke B G | 2002 | Defence Science J2002，52，2： | 1 |
| 13 | A review of new technologies in synthetic fiber production显示文摘 | MALCOLM B Polk SATISH Kumar | 1998 | Journal of Elasto- mers and Plastics1998，30，1： | 1 |
| 14 | Controlled release of album from chitosan-alginate microcapsules显示文摘 | Amsden B Yao K D | 1994 | J Pharm Sci1994，83，2： | 1 |
| 15 | Synthe-sis and characterization of 3,6-bis(lH-l,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine (BTATz):Novel high-nitrogen content insensitive high en-ergy material显示文摘 | Saikia A Sivabalan R Polke B G | 2009 | Journal of Hazardous Material2009，170，1： | 1 |
| 16 | Prehospital tracheal intubating conditions during rapid sequence intubation: rocuronium versus vecuronium显示文摘 | SMITH C E KOVACH B POLK J D etal | 2002 | Air Med J2002，21，： | 1 |
| 17 | Establishment of process technology for the manufacture of dinitrogen pentoxide and its utility for the synthesis of most powerful explosive of today-CL-20 显示文摘 | Taiawar M B Sivabalan R Polke B G | 2005 | Journa of Hazard Materials2005，124，： | 1 |
| 18 | Establishment of process technology for the manufacture of dinitrogen pentoxide and its utility for the synthesis of most powerful explosive of today-CL-20显示文摘 | Talawar M B Sivabalan R Polke B G | 2005 | Journa of Hazard Materials2005，124，： | 1 |
| 19 | Synthesis and Characterization of 3,6-Bis ( 1 H- 1,2,3,4-Tetrazol-5-Y1- amino) -1,2,4,5-Tetrazine (BTATz) : Novel High-Nitro- gen Content Insensitive High Energy Material 显示文摘 | Saikia A Sivabalan R Polke B G | 2009 | Jour- nal of Hazardous Materials2009，170，： | 1 |
| 20 | Mortality associated with nos ocomial urinary tract infection显示文摘 | Platt R Polk BF Murdock B | 1982 | N Engl J Med1982，307，： | 1 |
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