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| 1 | Molecular and cellular mechanism of cadmium carcinogenesis显示文摘 | Michael W Pius J Beverley H | 2003 | Toxicology2003，192，： | 1 |
| 2 | Manure sampling procedures and nutrient estimation by the hydrometer method for gestation pigs显示文摘 | ZHU J PIUS M N ZHANG Z J | 2004 | Bioresource Technology2004，，92： | 1 |
| 3 | PPAR gamma: observations in the hematopoietic system显示文摘 | Greene ME Pius J McCarville MA | 2000 | Prostaglan?dins Other Lipid Mediat2000，62，1： | 1 |
| 4 | Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos,c-jun,and c-myc proto-oncogenes:role of cellular calcium and reactive oxygen species显示文摘 | Pius J | 2001 | Toxicol Sci2001，16，2： | 1 |
| 5 | A stochastic approach to well spacing optimization of oil reservoirs显示文摘 | John M-P U Ibukun S Pius J | 2011 | SPE1507362011，，： | 1 |
| 6 | Two-dimensional electrode sensor for glucose显示文摘 | Lucisano J Y Pius H S | 1985 | Anal Chem1985，57，： | 1 |
| 7 | Relative pre-posi- tioning of storage/retrieval maehines in automated storage/ retrieval systems to minimize maximum system response time 显示文摘 | SUK-HWA CHANG PIUS J EGBELU | 1997 | IIE Transaetions1997，29，4： | 1 |
| 8 | Virtual cell formation显示文摘 | KUO-CHENG K PIUS J E | 2003 | International Journal of Production Research2003，41，11： | 1 |
| 9 | Heavy oil survey prepared for US department of energy 显示文摘 | Pius M J | 2006 | Oil & Gas Journal2006，104，4： | 1 |
| 10 | Enhanced plant regeneration in pearl millet (Pennisetum americanum) by ethylene inhibitors and cefotaxime显示文摘 | PIUS J GEORGE L EAPEN S | 1993 | Plant Cell Tiss Org Cult1993，32，： | 1 |
| 11 | Molecular and cellular mechanism of cadmium carcinogenesis显示文摘 | Michael W Pius j Beverley H | 2003 | Toxicology2003，192，： | 1 |
| 12 | Heavy oil survey prepared for US department of energy显示文摘 | Pius M J | 2006 | Oil & Gas Journal2006，104，4： | 1 |
| 13 | Molecular and cellular mechanism of cadmium carcinogenesis显示文摘 | Michael W Pius J Beverley H | 2003 | Toxicology2003，192，： | 1 |
| 14 | In vitro cytotoxicity of oxide nanoparticles:comparison to asbestos,silica,and the effect of particle solubility显示文摘 | Tobias J Brunner Peter Wick Pius Manser | 2006 | Environ Sci Technol2006，40，14： | 1 |
| 15 | An algorithm for minimizing weighted earliness penalty in assembly job shops显示文摘 | Supachai P Pius J E | 2006 | Int J of Production Economics2006，103，1： | 1 |
| 16 | Parkin gene mutations in younger onset Parkinson's disease显示文摘Objective': To screen for exonic and point mutations in the Parkin gene in both Chinese and American Caucasian younger onset Parkinson's disease (YOPD) patients.Background: Recently, the Autosomal recessive juvenile parkinsonism (ARJP) gene was first mapped to chromosome 6q25.2-27 and was late cloned and designated as Parkin. A wide variety of mutations, including homozygous exonic deletions and point mutations,have been found in at least more than 50 ARJP families of Japanese, European and Jewish origins. However, the distribution of Parkin gene mutations is not known in the Chinese and American Caucasians, It is also not clear how frequent the Parkin gene mutations occur in YOPD patients. Method and Material: Twenty-one Chinese subjects were selected from 121 Chinese PD inpatients who were admitted to the Xuanwu Hospital in Beijing between August of 1998 and April of 1999 and had an onset before age 51. Thirty-eight American subjects were PD patients with an onset before age 41 from the Tissue Bank of the Parkinson′s Institute at California. Homozygous exonic deletion and point mutations in all 12 exons of the Parkin gene were screened using PCR, SSCP and direct sequencing methods. Mutations identified by sequencing were further confirmed by restriction enzyme digestion. Results: Five different types of homozygous deletion mutations (exons 1, 4, 6, 7 and 12) were found in 7 out of 21 Chinese cases but none of the 37 American Caucasian patients in all 12 exons of Parkin gene. One novel and four polymorphic mutationswere found in the American Caucasian YOPD cases.Conclusion: our results suggest that homozygous exonic deletions in the Parkin gene may account for a significant amount of YOPD in the Chinese but not in the American Caucasian YOPD. | Piu Chan Hua Bai Rong Chen J Willian Langston | 2000 | 中国临床神经科学2000，8，z1： | 0 |
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