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| 1 | Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract显示文摘AIM: To investigate the indications, resection rate, and safety of endoscopic submucosal dissection (ESD) for neoplastic lesions in the gastrointestinal tract at a European referral center. METHODS: We carried out a retrospective analysis of the ESD procedures performed in our center for mucosal neoplastic and submucosal lesions of the gastrointestinal tract. The duration of the procedure, en bloc and complete (R0) resection rates, and complication rates were evaluated. Variables were reported as mean ± SD or simple proportions. Univariate analysis and comparisons of procedure times and resection rates were performed using Mann-Whitney U tests, or χ2 tests for dichotomous variables.RESULTS: Between 2007 and 2011, ESD was performed in a total of 103 patients (46.7% male, mean age 64.0 ± 12.7 years). The indications for the procedure were epithelial tumor (n = 54), submucosal tumor (n = 42), or other (n = 7). The total en bloc resection rate was 90.3% (93/103) and R0 resection rate 80.6% (83/103). The median speed of the procedure was 15.0 min/cm2 . The complete resection rate was lower for submucosal tumors arising from the muscle layer (68%, 15/22, P < 0.05). Resection speed was quicker for submucosal tumors localized in the submucosal layer than for lesions arising from the muscularis propria layer (8.1 min/cm 2 vs 17.9 min/cm 2 , P < 0.05). The R0 resection rate and speed were better in the last 24 mo (90.1%, 49/54 and 15.3 min/cm 2 ) compared to the first 3 years of treatment (73.5%, 36/49, P < 0.05 and 22.0 min/cm2 , P < 0.05). Complications occurred in 14.6% (n = 15) of patients, including perforation in 5.8% (n = 6), pneumoperitoneum in 3.9% (n = 4), delayed bleeding in 1.9% (n = 2), and other in 2.9% (n = 3). Only one patient with delayed perforation required surgical treatment. During the mean follow-up of 26 ± 15.3 mo, among patients with R0 resection, recurrence occurred in one patient (1.2%).CONCLUSION: ESD is an effective and safe method for resection of neoplastic lesions with low recurrence. Speed and the R0 resection rate increased after 50 procedures. | Andrzej Biaek Anna Wiechowska-Kozowska Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Piotr Milkiewicz Teresa Starzyńska | 2013 | World Journal of Gastroenterology2013，19，12： | 21 |
| 2 | Nodular regenerative hyperplasia:Evolving concepts on underdiagnosed cause of portal hypertension显示文摘Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules.NRH may lead to the development of non-cirrhotic portal hypertension.There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series.NRH may develop via autoimmune,hematological,infectious,neoplastic,or drug-related causes.The disease is usually asymptomatic,slowly or nonprogressive unless complications of portal hypertension develop.Accurate diagnosis is made by histopathology,which demonstrates diffuse micronodular transformation without fibrous septa.Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver.While the initial treatment is to address the underlying disease,ultimately the therapy is directed to the management of portal hypertension.The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension.In this review we detail the epidemiology,pathogenesis,diagnosis,management,and prognosis of NRH. | Marek Hartleb Krzysztof Gutkowski Piotr Milkiewicz | 2011 | World Journal of Gastroenterology2011，17，11： | 16 |
| 3 | Isolated right posterior bile duct injury following cholecystectomy:Report of two cases显示文摘Anatomic variations of the right biliary system are one of the most common risk factors for sectoral bile duct injury(BDI)during cholecystectomy.Isolated right posterior BDI may in particular be a challenge for both diagnosis and management.Herein we describe two cases of isolated right posterior sectoral BDI that took place during laparoscopic cholecystectomy.Despite effective external biliary drainage from the liver hilum in both cases,there was a persistent biliary leak observed which was not visible on endoscopic retrogradecholangiogram.Careful evaluation of images from both endoscopic and magnetic resonance cholangiograms revealed the diagnosis of an isolated right posterior sectoral BDI.These were treated with a delayed bisegmental(segments 6 and 7)liver resection and a Roux-en-Y hepaticojejunostomy respectively with good outcomes at 24 and 4 mo of follow-up.This paper discusses strategies for prevention of such injuries along with the diagnostic and therapeutic challenges it offers. | Maciej Wojcicki Waldemar Patkowski Tomasz Chmurowicz Andrzej Bialek Anna Wiechowska-Kozlowska Rafal Stankiewicz Piotr Milkiewicz Marek Krawczyk | 2013 | World Journal of Gastroenterology2013，19，36： | 5 |
| 4 | Health-related quality of life in autoimmune hepatitis显示文摘Autoimmune hepatitis(AIH)is a severe chronic autoimmune disease and has a significant impact on the patient’s quality of life,in particular regarding psychological problems such as anxiety and depression.Consistent evidence on which patient-related,disease-related or physician-related factors cause health-related quality of life(HRQoL)impairment in patients with AIH is lacking.Current studies on HRQoL in AIH are mainly single-centered,comprising small numbers of patients,and difficult to compare because of the use of different questionnaires,patient populations,and cutoff values.Literature in the pediatric field is sparse,but suggests that children/adolescents with AIH have a lower HRQoL.Knowledge of HRQoL and cohesive factors in AIH are important to improve healthcare for AIH patients,for example by developing an AIH-specific chronic healthcare model.By recognizing the importance of quality of life beyond the concept of biochemical and histological remission,clinicians allow us to seek enhancements and possible interventions in the management of AIH,aiming at improved health. | Romée JALM Snijders Piotr Milkiewicz Christoph Schramm Tom JG Gevers | 2021 | World Journal of Hepatology2021，13，11： | 1 |
| 5 | Esophageal duplication cysts:Endosonographic findings in asymptomatic patients显示文摘Esophageal duplication cysts are rare inherited lesions usually diagnosed in early childhood.Most of them are found in the mediastinum and manifest themselves as separate masses along or in continuity with the native esophagus.Their prevalence remains unknown and they are treated either surgically or endoscopically.In this report we describe a series of four adult patients in whom esophageal duplication cysts were localised intramurally as masses pressing on the esophageal lumen and who were diagnosed with endoscopic ultrasonography.All patients were initially referred to other centres for upper gastroduodenoscopy due to non-specific dyspeptic symptoms.After finding suspicious lesions in the esophagus their endoscopists referred them for endoscopic ultrasound examination at our centre.In two of the cases lesions mimicked esophageal varices and the other two submucosal tumours.In all four patients endoscopic ultrasonography has shown esophageal duplication cysts.Patients had no symptoms suggesting disease of the esophagus and required no treatment.As the true prevalence of esophageal cysts is unknown,it is very likely that in many patients,like in these four described by us,they may cause no symptoms,remain undetected and require no intervention.Increasing availability of new diagnostic modalities such as endoscopic ultrasonography may change the current view regarding the prevalence of esophageal duplication cysts and prove that they may,in fact,not be such rare findings. | Anna Wiechowska-Kozlowska Ewa Wunsch Marek Majewski Piotr Milkiewicz | 2012 | World Journal of Gastroenterology2012，18，11： | 1 |
| 6 | Endoscopic submucosal dissection for treatment of gastric subepithelial tumors (with video)显示文摘 | Andrzej Bia?ek Anna Wiechowska-Koz?owska Jan Pertkiewicz Marcin Polkowski Piotr Milkiewicz Katarzyna Karpińska Ma?gorzata ?awniczak Teresa Starzyńska | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 7 | Value of Autoantibody Analysis in the Differential Diagnosis of Chronic Cholestatic Liver Disease显示文摘 | Piotr Milkiewicz Hayman Buwaneswaran Catalina Coltescu Zakera Shums Gary L. Norman E. Jenny Heathcote | 2009 | Clinical Gastroenterology and Hepatology2009，，12： | 1 |
| 8 | PBC Screen: An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis显示文摘 | Haiying Liu Gary L. Norman Zakera Shums Howard J. Worman Edward L. Krawitt Nicola Bizzaro Diego Vergani Dimitrios P. Bogdanos George N. Dalekos Piotr Milkiewicz Albert J. Czaja E. Jenny Heathcote Gideon M. Hirschfield Eng M. Tan Kiyomitsu Miyachi Monica B | 2010 | Journal of Autoimmunity2010，，4： | 1 |
| 9 | PBC Screen: An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis显示文摘 | Haiying Liu Gary L. Norman Zakera Shums Howard J. Worman Edward L. Krawitt Nicola Bizzaro Diego Vergani Dimitrios P. Bogdanos George N. Dalekos Piotr Milkiewicz Albert J. Czaja E. Jenny Heathcote Gideon M. Hirschfield Eng M. Tan Kiyomitsu Miyachi Monica B | 2010 | Journal of Autoimmunity2010，，4： | 1 |
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