|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunohistochemical study of the digestive tract of Oligosarcus hepsetus显示文摘AIM: To describe the histology of the digestive tract and to investigate the occurrence of endocrine cells in Oligosarcus hepsetus (O. hepsetus ). METHODS: The digestive tract (DT) of O. hepsetus was divided into esophagus, two stomach regions (glandular and non-glandular) and two intestinal regions (anterior and posterior). These specimens were processed by routine histological techniques and stained with hematoxylin-eosin, Gomori's trichrome, periodic acid Schiff (PAS) and Alcian blue (AB). An immunohistochemical method using avidin-biotin-peroxidase was employed.RESULTS: The esophagus is lined with a non-keratinized stratified squamous epithelium that is reactive to PAS and AB. The stomach has a mucosa lined with a simple columnar epithelium with mucus-secreting cells that are reactive only to PAS. The intestine has a simple columnar epithelium with a brush border and goblet cells that are reactive to PAS and AB. Somatostatin, serotonin and cholecystokinin immunoreactive cells were identified throughout the DT.CONCLUSION: This study revealed adaptations for the species' diet and showed that the distribution and relative frequency of immunoreactive cells are similar to those of other fish. | Danielle A Vieira-Lopes Nadja L Pinheiro Armando Sales Adriana Ventura Francisco G Araújo Iracema D Gomes Aparecida A Nascimento | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 2 | Genetic deletion of the angiotensin (1 7) receptor Mas leads to glomerular hyperfiltration and microalbu minuria显示文摘 | Pinheiro S V Ferreira A J Kitten G T da Silveira K D da Silva D A Santos S H | 2009 | Kidney Int2009，75，： | 1 |
| 3 | High-throughput sequencing of black pepper root transcriptome显示文摘 | Gordo S M C Pinheiro D G Moreira E C | 2012 | BMC Plant Biology2012，12，： | 1 |
| 4 | Fluorescent reference strains of bacteria by chromosomal integration of a modified green fluorescent protein gene显示文摘 | Pinheiro L B Gibbs M D Vesey G Smith J J Bergquist P L | | 0，，06： | 1 |
| 5 | Complete inventory of soybean NAC transcription factors: Sequence conservation and expression analysis uncover their distinct roles in stress response 显示文摘 | Pinheiro G L Marques C S Costa M D | 2009 | Gene2009，444，12： | 1 |
| 6 | Twenty- three years of hypersensitivity pneumonitis mortality surveil- lance in the United States显示文摘 | Bang K M Weissman D N Pinheiro G A | 2006 | Am J Ind Med2006，49，12： | 1 |
| 7 | Particle capture in porous media when physico-chemical effects dominate显示文摘 | PINHEIRO I G SCHMITZ P HOUI D | 1999 | Chemical Engineering Science1999，54，17： | 1 |
| 8 | A global-ranking local feature selection method for text categorization显示文摘 | Pinheiro R H W Cavalcanti G D C Correa R F | 2012 | Expert Systems with Appli- cations2012，39，12： | 1 |
| 9 | The burden of chronic mercury intoxication in artisanal small-scale gold mining in Zimbabwe:data availability and preliminary estimates显示文摘 | Steckling N Bose-O'Reilly S Pinheiro P Plass D Shoko D Drasch G | 2014 | Environ Health2014，13，： | 1 |
| 10 | Complete inventory of soybean NAC transcription factors : sequence conservation and expression analy- sis uncover their distinct roles in stress response 显示文摘 | Pinheiro G L Marques C S Costa M D | 2009 | Gene2009，444，： | 1 |
| 11 | A global-ranking local feature selection method for text categorization显示文摘 | PINHEIRO R H W CAVALCANTI G D C CORREA R F | 2012 | Expert Systems with Applications2012，39，12： | 1 |
| 12 | Particle,capture in porous media when physico-chemical effects dominate显示文摘 | Pinheiro I G Schmitz P Houi D | 1999 | Chemical Engineering Science1999，54，： | 1 |
| 13 | Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil显示文摘BACKGROUND Crohn’s disease(CD)and ulcerative colitis(UC)are inflammatory bowel diseases(IBDs)with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden,especially in patients with moderate-to-severe disease.The Real-world Data of Moderate-to-Severe Inflammatory Bowel Disease in Brazil(RISE BR)study was a noninterventional study designed to evaluate disease control,treatment patterns,disease burden and health-related quality of life in patients with moderate-to-severe active IBD.We report findings from the prospective follow-up phase of the RISE BR study in patients with active UC or CD.AIM To describe the 12-mo disease evolution and treatment patterns among patients with active moderate-to-severe IBD in Brazil.METHODS This was a prospective,noninterventional study of adult patients with active Crohn’s disease(CD:Harvey-Bradshaw Index≥8,CD Activity Index≥220),inadequate CD control(i.e.,calprotectin>200μg/g or colonoscopy previous results),or active ulcerative colitis(UC:Partial Mayo score≥5).Enrollment occurred in 14 centers from October 2016 to February 2017.The proportion of active IBD patients after 9-12 mo of follow-up,Kaplan-Meier estimates of the time to mild or no activity and a summary of treatment initiation,discontinuation and dose changes were examined.RESULTS The study included 118 CD and 36 UC patients,with mean±SD ages of 43.3±12.6 and 44.9±16.5 years,respectively.The most frequent drug classes at index were biologics for CD(62.7%)and 5-aminosalicylate derivates for UC patients(91.7%).During follow-up,65.3%of CD and 86.1%of UC patients initiated a new treatment at least once.Discontinuations/dose changes occurred in 68.1%of CD patients[median 2.0(IQR:2-5)]and 94.3%of UC patients[median 4.0(IQR:3-7)].On average,CD and UC patients had 4.4±2.6 and 5.0±3.3 outpatient visits,respectively.The median time to first mild or no activity was 319(IQR:239-358)d for CD and 320(IQR:288-358)d for UC patients.At 9-12 mo,22.0%of CD and 20.0%of UC patients had active disease.CONCLUSION Although a marked proportion of active IBD patients achieved disease control within one year,the considerable time to achieve this outcome represents an unmet medical need of the current standard of care in a Brazilian real-world setting. | Ligia Yukie Sassaki Sender J Miszputen Roberto Luiz Kaiser Junior Wilson R Catapani Mauro Bafutto António S Scotton Cyrla Zaltman Julio Pinheiro Baima Hagata S Ramos Mikaell Alexandre Gouvea Faria Carolina D Gonçalves Isabella Miranda Guimaraes Cristina Flores Heda M B S Amarante Rodrigo Bremer Nones JoséMiguel Luz Parente Murilo Moura Lima Júlio Maria Chebli Maria de Lourdes Abreu Ferrari Julia F Campos Maria G P Sanna Odery Ramos Rogério Serafim Parra Jose J R da Rocha Omar Feres Marley R Feitosa Rosana Fusaro Caratin Juliana Tosta Senra Genoile Oliveira Santana | 2021 | World Journal of Gastroenterology2021，27，23： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员