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| 1 | Synthesis and antiviral bioactivities of novel chiral bis-thiourea-type derivatives containing α-aminophosphonate moiety显示文摘Starting from 1-((1R,2R)-2-aminocyclohexyl)-3-substituted thioureas (3a–c) and substituted isothiocyanates (9a–d),chiral bis-thiourea derivatives containing α-aminophosphonate moiety 10a–l were prepared and completely characterized by elemental analysis,physical and spectral (IR,1H NMR,13C NMR,31P NMR) data.The results of bioassay revealed that compounds 10a and 10e possessed appreciable curative bioactivities on cucumber mosaic virus (CMV) at 0.5 mg/mL in vivo (inhibitory rate = 60.3%,64.8% respectively) and tobacco mosaic virus (TMV) at 0.5 mg/mL in vivo (inhibitory rate = 50.3%,50.8% respectively),which were comparable to the values shown by standard reference (58.7%) and commercial product Ningnanmycin (56.3%),respectively.Chiral compound 10e displayed more potent antiviral activity (EC50 = 0.149 mg/mL) than Ningnanmycin (EC50 = 0.201mg/mL) against CMV. | YANG Xuan SONG BaoAn JIN LinHong WEI Xue BHADURY S Pinaki LI XiangYang YANG Song HU DeYu | 2011 | Science China Chemistry2011，54，1： | 5 |
| 2 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 3 | Radionuclide remediation using a bacterial biosorbent显示文摘 | Pinaki Sar Sufia K Kazy Souza S F D' | 2004 | International Biodeterioration & Biodegradation2004，54，： | 1 |
| 4 | Suprasellar tubercular abscess presenting as panhypopituitarism:A common lesion in an un-common site with a brief review of literature显示文摘 | Pinaki D Anil B Paramjeet S | 2006 | Pituitary2006，9，1： | 1 |
| 5 | Radionuclide remediation us-ing a bacterial biosorbent显示文摘 | Pinaki S Sufia K Kazy S F | 2004 | International Biodeterioration and Biodegradation2004，54，4： | 1 |
| 6 | Synthesis and antifungal activity of novels--substituted-6-fluoro--alkyl (aryl)thioquinazoline derivatives显示文摘 | Xu G F Song B A Pinaki S B | 2007 | Bioorg Med Chem2007，15，： | 1 |
| 7 | Deconvolution Methods for 3-D Fluorescence Microscopy Images 显示文摘 | Pinaki S Arye N | 2006 | IEEE Signal Processing Magzine2006，2006，： | 1 |
| 8 | Adsorption of Cr(Ⅵ) in layered double hydroxides显示文摘 | Rajib L G Pinaki S Krishna G B Dipak K D | 1998 | Applied Clay Science1998，13，1： | 1 |
| 9 | Copper uptake and its compartmentalization in Pseudomonas aeruginosa strains:Chemical nature of celluar metal 显示文摘 | Kazy S K Pinaki S R Asthana R K | 1999 | World Journal of Microbiology & Biotechnology1999，15，： | 1 |
| 10 | Bricks from petroleum effluent treatment plant sludge:properties and environmental characteristics 显示文摘 | Pinaki S Nabajyoti S Prakash C B | 2002 | Journal of Environmental Engineering2002，128，11： | 1 |
| 11 | Uranium biomineralization by a metal resistant Pseudomonas aeruginosa strain isolated from contaminated mine waste显示文摘 | Sangeeta C Pinaki S | 2011 | Journal of Hazardous Materials2011，186，1： | 1 |
| 12 | Bricks from petroleum effluent treatment plant sludge:properities and enviromental characteristics显示文摘 | Nabajyoti S Prakash C B | 2002 | Journal of Enviromental Engineering2002，，： | 1 |
| 13 | Catalytic synthesis of optically active t-amino acid derivatives 显示文摘 | Pinaki S B Song Y Bao A S | 2012 | Current Organic Synthesis2012，9，： | 1 |
| 14 | Radionuclide remediation using a bacterial biosorbent 显示文摘 | Sar Pinaki Kazy S K D'Souza S F | 2004 | International Biodeterioration & Biodegradation2004，54，23： | 1 |
| 15 | Synthesis and an- tifungal activity of novels-substituted-6-fluoro-4-alkyl ( ar- yl) thioquinazoline derivatives 显示文摘 | Guang F X Bao A S Pinaki S B | 2007 | Bioorg Med Chern2007，15，： | 1 |
| 16 | Radionuclide remedia tion using a bacterial biosorbent 显示文摘 | Pinaki Sar Sufia K Kazy S F D' Souza | 2004 | International Biodeterioration & Biodegradation2004，54，： | 1 |
| 17 | Uranium sorption by Pseudomonas biomass immobilized in radiation polymerized polyacrylamide bio-Beads 显示文摘 | D'Souza S F Pinaki S Kazy S K | 2006 | J Environ Sci Health (Part A)2006，41，3： | 1 |
| 18 | Synthesis and antifungal activity of novel s-substituted 6 -fluoro -4-alkyl (aryl) thioquinazoline derivatives 显示文摘 | Xu G F Song B A Pinaki S | 2007 | Bioorg Med Chem2007，15，： | 1 |
| 19 | Microbial communities in uranium mine tailing and mine water sediment fron Jaduguda U mine, India:A culture independent analysis 显示文摘 | KUMAR D P PINAKI S | 2014 | Journal of Environmental Science & Health Part A :Toxic/hazardous Substances & Environmental Engineering2014，49，6： | 1 |
| 20 | Synthesis and antifungal activity of novels-substituted-6-fluoro-4-alkyl(aryl) thioquinazoline derivatives显示文摘 | Xu G F Song B A Pinaki S B | | 0，，15： | 1 |
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