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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Degradation Mechanisms of Vertical Cavity Surface Emitting Lasers, Quantum Electronics显示文摘 | Michael C Y Robert W H Pierre M P | 1996 | IEEE Journal1996，32，： | 2 |
| 3 | Dynamic response predictions for a mistuned industrial turbo machinery rotor using reduced-order modeling显示文摘 | Bladh R Pierre C Castanier M P | 2002 | Journal of Engineering for Gas Turbines and Power2002，124，2： | 1 |
| 4 | Polarization properties of birefringenee gratings显示文摘 | Pierre P F Doueen M L | 1995 | Optik1995，100，： | 1 |
| 5 | RnKSN, a floral repressor, forms protein complexes with RoFD and RoFT to regulate vegetative and reproductive development in rose 显示文摘 | RANDOUX M DAVIERE J M JEAUFFRE J THOUROUDE T PIERRE S TOUALBIA Y PERROTTE J REYNO1RD J P JAMMES M J HIBRAND-SAINT OYANT L FOUCHER F | 2014 | New Phytologist2014，202，1： | 1 |
| 6 | Influence of key parameters on drying shrinkage of cementitious mate- rials显示文摘 | Bissonnette B Pierre P Pigeon M | 2003 | Cement and Structure2003，29，10： | 1 |
| 7 | Reduced order modeling and vibration analysis of mistuned bladed disk assemblies with shrouds显示文摘 | Castanier M P Ottarsson G Pierre C | 1999 | Journal of Engineering for Gas Turbine and Power1999，121，： | 1 |
| 8 | Effects of multistage coupling and disk flexibility on mistuned bladed disk dynamics 显示文摘 | Bladh R Castanier M P Pierre C | 2003 | Journal of Engineering for Gas Turbines and Power2003，125，1： | 1 |
| 9 | Modeling and analysis of mistuned bladed disk vibration: status and emerging directions 显示文摘 | Castanier M P Pierre C | 2006 | Journal of Propulsion and Power2006，22，2： | 1 |
| 10 | Influence of key parameters on drying shrinkage of cementitious materials 显示文摘 | Bissonnette B Pierre P Pigeon M | 2003 | Cement and Structure2003，33，： | 1 |
| 11 | Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity显示文摘 | PIERRE M ONGE S JONES P J H | 2002 | The American Society for Nutritional Sciences: Journal of Nutrition2002，132，： | 1 |
| 12 | Influence of Key Parameters on Drying Shrinkage of Cementitious Materials 显示文摘 | Bissonnette B Pierre P Pigeon M | 1999 | Cement and Concrete Research1999，29，10： | 1 |
| 13 | Character- istic constraint modes for component mode synthesis 显示文摘 | CASTANIER M P TAN Y C PIERRE C | 2001 | AIAA Journal2001，39，6： | 1 |
| 14 | Zone of T-wave excitation in the NE Indian Ocean mapped using variations in backazimuth over time obtained from multi-channel correlation of IMS hydrophone triplot data 显示文摘 | Frank M G Pierre F P | 2004 | Geophys J Int2004，158，： | 1 |
| 15 | Characteristic constraint modes for component mode synthesis 显示文摘 | Castanier M P Tan Y C Pierre C | 2001 | 39 (6) :2001，39，6： | 1 |
| 16 | Lyapunov exponents and localization phenomena in multi-coupled nearly periodic system 显示文摘 | CASTANIER M P PIERRE C | 1995 | Journal of Sound and Vibration1995，183，3： | 1 |
| 17 | Steroid saponins from fenugreek seeds:extraction,purification,and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R P Yves D S Dominique M H | 1995 | Steroids1995，60，10： | 1 |
| 18 | Modeling and analysis of mistuned bladed disk vibration:current status and emerging directions显示文摘 | Castanier M P Pierre C | | 0，，02： | 1 |
| 19 | Effects of a cracked blade on mistuned turbine engine rotor vibration显示文摘 | Saito A Castanier M P Pierre C | 2009 | Journal of Vibration and Acoustics2009，131，6： | 1 |
| 20 | Two-dimensionalmodeling of an aircraft engine structural bladed disk-casingmodal interaction显示文摘 | Legrand M Pierre C Cartraud P | 2009 | Journal of Sound and Vibration2009，319，12： | 1 |
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