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| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Complete reversal of paraplegia after thoracic endovascular aortic repair in a patient with complicated acute aortic dissection using immediate cerebrospinal fluid drainage显示文摘 | Holger Eggebrecht Dirk B?se Thomas Gasser Jaroslav Benedik Petra Mummel Oliver Müller Philipp Kahlert Konstantinos Tsagakis Heinz G. Jakob Raimund Erbel | 2009 | Clinical Research in Cardiology2009，，12： | 1 |
| 3 | Blue Light-Emitting DiodesGrown on ZnO Substrates显示文摘 | Yuanyang Xia Julien Brault^Benjamin Damilano^Se'bastien Chenot Philippe Venne'gue's’Maud Nemoz Monique Teisseire’Mathieu Leroux Re my Obrecht Ivan-Christophe Robin Jean-Louis Santailler GuyFeuillet and Jean-Michel Chauveau etal | 2013 | The Japan Society of Applied Physics2013，6，： | 1 |
| 4 | Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells显示文摘 | Philipp Saiko Geraldine Graser Benedikt Giessrigl Marie-Thérèse Steinmann Heike Schuster Andreas Lackner Michael Grusch Georg Krupitza Walter Jaeger Venkateswarlu Somepalli Trimurtulu Golakoti Monika Fritzer-Szekeres Thomas Szekeres | 2013 | Investigational New Drugs2013，，5： | 1 |
| 5 | Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa显示文摘 | Julien Bertrand Alexis Goichon Philippe Chan Saida Azhar Stéphane Lecleire Nathalie Donnadieu David Vaudry Anne-Fran?oise Cailleux Pierre Déchelotte Mo?se Co?ffier | 2014 | Amino Acids2014，，4： | 1 |
| 6 | TRPM3显示文摘 | Oberwinkler J Philipp SE | 2007 | Handb Exp Pharmacol2007，179，： | 1 |
| 7 | TRPM3 is a nociceptor channel involved in the detection of noxious heat显示文摘 | Vriens J Owsianik G Hofmann T Philipp SE Stab J Chen X | 2011 | Neuron2011，70，3： | 1 |
| 8 | TRPM3显示文摘 | Oberwinkler J Philipp SE | 2014 | Handb Exp Pharmacol2014，222，： | 1 |
| 9 | Antagonistic effects of interferon-Rand interleukin-4 on fibroblast cultures 显示文摘 | HERVE S PHILIPPE G VERONIQUE SE | 1997 | J Invest Dermatol1997，109，2： | 1 |
| 10 | Determinants of oxidant stress in extremely low birth weight premature infants显示文摘 | Philippe Chessex Carla Watson Gregor W. Kaczala Thérèse Rouleau Marie-Eve Lavoie James Friel Jean-Claude Lavoie | 2010 | Free Radical Biology and Medicine2010，，9： | 1 |
| 11 | Antagonistic effects of interferon-Rand interleukin-4 on fibroblast cultures 显示文摘 | PHILIPPE G VERONIQUE SE | 1997 | J Invest Dermatol1997，109，2： | 1 |
| 12 | Chemosphere显示文摘 | Ronkart Se'bastien N Laurent Vincent Carbonnelle Philippe | 2007 | 66(4):7382007，66，4： | 1 |
| 13 | Intracellular vs extracellular recognition of pathogens common concepts in mammals and flies显示文摘 | Girardin SE Philippe J Philpott DJ | 2002 | Trends Microbiol2002，10，4： | 1 |
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