|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Comparison of real-time threedimensional echocardiography with cardiovascular magnetic resonance for left ventricular volumetric assessment in unselected patients显示文摘 | Christopher AM Keith P Peter J | | 0，，02： | 1 |
| 3 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 4 | Uncomplicated urinary tract infection in women: Current practice and the effect of antibiotic resistance on empiric treatment显示文摘 | Lindsay N Peter AM Anderson J | 2006 | Canadian Family Physician2006，52，6： | 1 |
| 5 | The numerical design of a parallel plate flow chamber for investigation of endothelial cell response to shear stress 显示文摘 | Chung B J Robertson AM Peters DG | 2003 | Comput Struct2003，81，： | 1 |
| 6 | Adiponectin is presented in cord blood but unrelated to birth weight显示文摘 | Robert SL J ames DW Peter J H | 2003 | Diabetes Care2003，26，8： | 1 |
| 7 | Oil Chem显示文摘 | J S Peter J Am | 1984 | Soc1984，61，2： | 1 |
| 8 | Monoclonal antibody-mediated tumor regression by induction of aopotosis 显示文摘 | Trauth BC Klas C Peters AM J | 1989 | Science1989，245，32： | 1 |
| 9 | Corticosteroids in the prevention and treatment of acute respiratory distress syndrome(ARDS) in adults : meta-analysis 显示文摘 | Recruitment nmneuvers for acute Am J Respir Crit Care Med Peter JV John P Graham PL | 2008 | BMJ2008，336，7651： | 1 |
| 10 | Monoclonal antibody mediated tumor regression by induction of apoptosis显示文摘 | Trauth BC Klas C Peters AM J | 1989 | Science1989，245，： | 1 |
| 11 | Non-invasive measurements of renal blood flow with 99mTc DTPA: a comparison with radiolabelled microspheres显示文摘 | Peters AM Brown J Hartnell GG | 1987 | Cardiovascular Research1987，21，： | 1 |
| 12 | Pain, and Why We Need It 显示文摘 | Fan HC Lee Y J Peter AM | 2009 | Journal of Medical Sciences2009，29，5： | 1 |
| 13 | L Effectiveness of P2AM (PAM-Pmlidoxime) in the treatment of organophosphoras (OPP) : arandomized double blind placebo controlled trial 显示文摘 | Cherian AM Peter JV Samuel J et a | 1997 | Journal of the Association of Physicians of India1997，，： | 1 |
| 14 | FL1CE, a novel FADD-homologous ICE/CED-3 like protease is recuited to the CD95 (Fas/Apo-1) death inducing signaling complex 显示文摘 | Muzio M Kischkel FC Schevchenko A Bretz JD Mann M Peter ME Chinnaiyan AM O'Rourke K Dixit VM Ni J Scaffidi C Zhang M Gentz R Krammer PH | 1996 | Cell1996，85，： | 1 |
| 15 | Mutations in OTOGL,encoding the in-ner ear protein otogelin-like,cause moderate sensorineural hear-ing loss显示文摘 | Yariz KO Duman D Seco CZ Dallman J Huang M Peters TA Sirmaci A Lu N Schraders M Skromne I Oostrik J Di-az-Horta O Young JI Tokgoz-Yilmaz S Konukseven O Shahin H Hetterschijt L Kanaan M Oonk AM Edwards YJ Li H Ata-lay S Blanton S Desmidt AA Liu XZ Pennings | | 0，，： | 1 |
| 16 | Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial显示文摘 | Aimée HMM Arits Klara Mosterd Brigitte AB Essers Eefje Spoorenberg Anja Sommer Michette JM De Rooij Han PA van Pelt Patricia JF Quaedvlieg Gertruud AM Krekels Pierre AFA van Neer Joris J Rijzewijk Adrienne J van Geest Peter M Steijlen Patty J Nelemans Nic | 2013 | Lancet Oncology2013，，7： | 1 |
| 17 | The numerical design of a parallel plate flow chamber for investigation of endothelial cell response to shear stress 显示文摘 | Chung B J Robertson AM Peters DG | 2003 | Comput Struct2003，81，8： | 1 |
| 18 | Subclinical renal dysfunction is independently associated with cardiovascular events in rheumatoid arthritis: the CARRE Study 显示文摘 | van Sijl AM van den Oever IA Peters M J | 2012 | Ann Rheum Dis2012，71，3： | 1 |
| 19 | Non-invasive measurements of renal blood flow with 99mTc DTPA:a comparison with radiolabelled microspheres显示文摘 | Peters AM Brown J Hartnell GG | 1987 | Cardiovascular Research1987，21，1： | 1 |
| 20 | Imaging of inflammation with indium-111 tropolonate labeled leukocytes显示文摘 | Peters AM Saverymuttu SH Reavy H J | 1983 | J Nucl Med1983，24，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员