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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases 显示文摘 | Garcia--Cao M O'Sullivan R Peters AH | 2004 | Nat Genet2004，36，1： | 1 |
| 4 | A salt wasting sundrome associate with cerebral disease显示文摘 | Peter JB Welt KG Sims E AH | 1950 | Trans Ass Am Phtsiol1950，63，： | 1 |
| 5 | Tissue factor and coronary artery disease显示文摘 | Moons AH Levi M Peters RJ | 2002 | Cardiovasc Res2002，53，2： | 1 |
| 6 | Preservation of pancreatic bata-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women显示文摘 | Buchanan TA Xiang AH Peters RK | 2002 | Diabetes2002，51，9： | 1 |
| 7 | Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component 显示文摘 | Maison C Bailly D Peters AH | 2002 | Nat Genet2002，30，3： | 1 |
| 8 | Tissue factor and coronary artery disease显示文摘 | Moons AH Levi M Peters RJ | 2002 | Cardiovasc Res2002，53，2： | 1 |
| 9 | Power Dopplerrendering of fetal bilateral accessory renal arteries in virtual reality显示文摘 | Bazelmans M Peters NC Koning AH | 2014 | Ultrasound Obstet Gynecol2014，44，3： | 1 |
| 10 | Management of upper gastrointestinal haemorrhage complicating dual anti-platelet therapy显示文摘 | Peter AH Kekvin P Nick AB | 2008 | Q J Med2008，101，： | 1 |
| 11 | Tissue factor and coronary artery disease显示文摘 | Moons AH Levi M Peters RJ | 2002 | Cardiovasc Res2002，53，： | 1 |
| 12 | Tissue factor and coronary artery disease显示文摘 | Moons AH Levi M Peters R | 2002 | Cardiovasc Res2002，53，： | 1 |
| 13 | Preserves of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women显示文摘 | Buchanan TA Xiang AH Peters RK | 2002 | Diabetes2002，51，： | 1 |
| 14 | Asalt wasting syndrome- associated with cerebml disease 显示文摘 | Peters JB Welt KG Simse AH | 1950 | Tans Assam Physiol1950，63，： | 1 |
| 15 | A salt wasting syndrome associated with cerebral disease显示文摘 | Peters JB Welt KG Simse AH | 1950 | Trans Ass amPhysiol1950，63，： | 1 |
| 16 | Preservation of pancreatic bete-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women显示文摘 | Buchanan TA Xiang AH Peters RK etal | 2002 | Diabetes2002，51，9： | 1 |
| 17 | ATM and RPA in meioticchromosome synapsis and recombination 显示文摘 | Plug AW Peters AH Xu Y | 1997 | Nat Genet1997，17，4： | 1 |
| 18 | Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women显示文摘 | Buchanan TA Xiang AH Peters RK | 2002 | Diabetes2002，51，9： | 1 |
| 19 | Tissue Factor and coronary artery disease 显示文摘 | Moons AH Levi M Peters RJ | 2002 | Cardiovasc Res2002，53，2： | 1 |
| 20 | Tissue factor and coronary artery disease显示文摘 | Moons AH Levi M Peters RJ | 2002 | Cardiovasc Res2002，53，： | 1 |
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