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| 1 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | 非小细胞肺癌驱动基因HER2插入突变的靶向治疗显示文摘人类表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)基因突变,在框内插入大量的20号外显子,在1%-4%的非小细胞肺癌中,专门针对腺癌组织学类型,已经被认为是一种致癌驱动改变。这些改变的预后性意义仍然未知。I期和II期的试验数据表明:阿法替尼、来那替尼和dacomitinib对这些分子亚型组有一些活性。目前没有任何关于帕妥珠单抗或曲妥单抗-emtansine活性的资料可供使用,HER2的反常可以导致蛋白的过表达或者基因的扩增,迄今为止,有很少的临床相关性研究,曲妥单抗活性的试验研究仅仅表明对于极少数过表达HER2的患者有益,这一亚群占大多数腺癌的2%-6%。 | Solange Peters Stefan Zimmermann 魏建国 许春伟 张博 | 2015 | 临床与病理杂志2015，35，2： | 2 |
| 3 | Dual-polarization wavelength conversion of 16-QAM signals in a single silicon waveguide with a lateral p-i-n diode[Invited]显示文摘A polarization-diversity loop with a silicon waveguide with a lateral p-i-n diode as a nonlinear medium is used to realize polarization insensitive four-wave mixing. Wavelength conversion of seven dual-polarization 16-quadrature amplitude modulation(QAM) signals at 16 GBd is demonstrated with an optical signal-to-noise ratio penalty below 0.7 dB. High-quality converted signals are generated thanks to the low polarization dependence(≤0.5 dB) and the high conversion efficiency(CE) achievable. The strong Kerr nonlinearity in silicon and the decrease of detrimental free-carrier absorption due to the reverse-biased p-i-n diode are key in ensuring high CE levels. | FRANCESCO DA Ros ANDRZEJ GAJDA ERIK LIEBIG EDSON P.DA SILVA ANNA PECZEK PETER D.GIROUARD ANDREAS MAI KLAUS PETERMANN LARS ZIMMERMANN MICHAEL GALILI LEIF K.OXENLOWE | 2018 | Photonics Research2018，6，5： | 1 |
| 4 | Erratum to: CT enterography of pediatric Crohn disease显示文摘 | Jonathan R. Dillman Jeremy Adler Ellen M. Zimmermann Peter J. Strouse | 2010 | Pediatric Radiology2010，，： | 1 |
| 5 | Hepatic encephalopathy in thioacetamide - induced acute liver failure in rat : characterization of improve model and study of aminoacidergic neurotransmission显示文摘 | Zimmermann C Peter F Christian P | 1989 | Hepatology1989，9，4： | 1 |
| 6 | Echocardiographic Monitoring During Induction of General Anesthesia with a Miniaturized Esophageal Probe显示文摘 | Peter Zimmermann Clemens Greim Herbert Trautner Ulrich Sagmeister Katharina Kraemer Norbert Roewer | 2003 | Anesthesia & Analgesia2003，，1： | 1 |
| 7 | Risk factors for failure of endoscopic stenting of biliary strictures in chronic pancreatitis: a prospective follow-up study显示文摘 | Stefan Kahl Sandra Zimmermann Ingo Genz B Glasbrenner Matthias Pross Hans-Ulrich Schulz Deirdre Mc Namara Uwe Schmidt Peter Malfertheiner | 2003 | The American Journal of Gastroenterology2003，，11： | 1 |
| 8 | Indications and limi- tations of chemotherapy and targeted agents in non-small cell lung cancer brain metastases 显示文摘 | Zimmermann S Dziadziuszko R Peters S | 2014 | Cancer Treat Rev2014，40，6： | 1 |
| 9 | Antiviral triple therapy with boceprevir in a chronic hepatitis C haemodialysis patient awaiting kidney re-transplantation显示文摘 | Johanna Knapstein Peter R. Galle Tim Zimmermann | 2014 | Digestive and Liver Disease2014，，1： | 1 |
| 10 | Medically unexplained physical symptoms, anxiety, and depression: A Metaanalytic review显示文摘 | Peter nenningsen Thomas Zimmermann Dipl Psych | 2003 | Psychosomatic Medicine2003，65，： | 1 |
| 11 | Optimization of carbohydrate fatty acid ester synthesis in organic media by a lipase from Candida antarctica 显示文摘 | Peter Degn Wolfgang Zimmermann | 2001 | Biotechnology and bioengineering2001，74，： | 1 |
| 12 | Downregulation of organic cation transporter 1 (SLC22A1) is associatedwith tumor progression and reduced patient survival in human cholangiocellularcarcinoma显示文摘 | Anja Lautem Michael Heise Andreas Gr?sel Maria Hoppe?Lotichius Nina Weiler Daniel Foltys Johanna Knapstein J?rn Schattenberg Arno Schad Anca Zimmermann Gerd Otto Hauke Lang Peter Galle Marcus Schuchmann Tim Zimmermann | 2013 | International Journal of Oncology2013，，4： | 1 |
| 13 | Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: comparative pharmacokinetics and drug-drug interactions 显示文摘 | PETERS S ZIMMERMANN S ADJEI AA | 2014 | Cancer Treat Rev2014，40，8： | 1 |
| 14 | 显示文摘 | Zimmermann Wolfgang | 2001 | Biotechnology and Bioengineering2001，74，6： | 1 |
| 15 | Deficiency of the mitochondrial phosphate carrier presenting as myopathy and cardiomyopathy in a family with three affected children显示文摘 | Johannes A. Mayr Franz A. Zimmermann Rita Horváth Hans-Christian Schneider Benedikt Schoser Elke Holinski-Feder Birgit Czermin Peter Freisinger Wolfgang Sperl | 2011 | Neuromuscular Disorders2011，，11： | 1 |
| 16 | The effects of body size and temperature on metabolic rate of organisms显示文摘 | Robinson W R Peters R H Zimmermann J | 1983 | Can J Zool1983，61，： | 1 |
| 17 | Optimal lines for railway systems显示文摘 | Bussieck Michael R Kreuzer Peter Zimmermann Uwe T | 1997 | European Journal of Opera- tional Research1997，96，1： | 1 |
| 18 | Mercury, cadmium and lead concentrations in different ecophysiological groups of earthworms in forest soils显示文摘 | Gregor Ernst Stefan Zimmermann Peter Christie Beat Frey | 2008 | Environmental Pollution2008，，3： | 1 |
| 19 | Indications and limitations of chemotherapy and targeted agents in non small cell lung cancer brain metastases显示文摘 | Zimmermann S Dziadziuszko R Peters S | 2014 | Cancer Treat Re''v2014，40，6： | 1 |
| 20 | TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis显示文摘 | Maya Zimmermann Andrea Koreck Norbert Meyer Tomasz Basinski Flurina Meiler Burgler Simone Stefan Woehrl Katharina Moritz Thomas Eiwegger Peter Schmid-Grendelmeier Lajos Kemeny Cezmi A. Akdis | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 1 |
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