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| 1 | Efficacy,safety,and adherence with a twice-daily combination lamivudine/zidovudine tablet formulation,plus a protease inhibitor,in HIV infection显示文摘 | Eron Joseph J Yetzer Ellen S Ruane Peter J | 2000 | AIDS2000，14，6： | 1 |
| 2 | Thyroid Nodule Size and Prediction of Cancer显示文摘 | Sophia C. Kamran Ellen Marqusee Mathew I. Kim Mary C. Frates Julie Ritner Hope Peters Carol B. Benson Peter M. Doubilet Edmund S. Cibas Justine Barletta Nancy Cho Atul Gawande Daniel Ruan Francis D. Moore Karla Pou P. Reed Larsen Erik K. Alexander | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，2： | 1 |
| 3 | Isolation and characterization of rhizobitoxinemutants of Bradyrhizobium japonicum显示文摘 | Ruan X Peters N K | 1992 | Journal of Bacteriology1992，174，11： | 1 |
| 4 | Chemical Diversity Investigation of Hepatotoxic Pyrrolizidine Alkaloids in Qianliguang(Senecio scandens)and Related Species by UHPLC-QTOF-MS显示文摘Objective: Qianliguang(Senecio scandens) is a common Chinese medicinal herb. Qianliguang-containing herbal proprietary products are registered as over-the-counter remedies in China and exported to Western countries. The presence of hepatotoxic pyrrolizidine alkaloids(PAs)has raised concerns about the safety of using Qianliguang and its products. The present study aims at investigation of different types of PAs present in Qianliguang collected from representative locations in China.Methods: In this study, a simple but specific UHPLC-QTOF-MS method for the determination of toxic PAs was developed, based on the characteristic fragment ions specific to different types of PAs. It was successfully applied for the identification and distinguishing of PAs present in Qianliguang and related Senecio species growing in different locations of China.Results: Significant diversity of the PA types and quantities were revealed among the samples tested. The estimated total amounts of toxic PAs in three of the samples exceed the toxic limits of PA intake restricted by WHO, demonstrating the timely and highly demand for regulating both types and quantities of PAs present in Qianliguang.Conclusions: This study provides the methodology for simultaneous identification and quantification of PAs present in herbs without requiring corresponding standards, which could be further used for more systematic investigations of the PA distribution in Qianliguang and other PA-containing herbs. | Lin Zhu Na Li Jian-Qing Ruan Peter P.Fu Zhong-Zhen Zhao Ge Lin | 2015 | World Journal of Traditional Chinese Medicine2015，1，2： | 1 |
| 5 | POWER1和2试验中对曾治疗HIV-1感染患者给予地瑞那韦-利托那韦治疗48周时的疗效与安全性:2项随机试验资料的合并亚组分析显示文摘背景连续、随机、多国性POWER1和2ⅡB期研究旨在评价地瑞那韦(darunavir)联合应用小剂量利托那韦(ritonavir)对曾治疗HIV-1感染患者的疗效与安全性。本文作者进行了一项合并的亚组分析,对接受推荐剂量地瑞那韦-利托那韦的患者与接受其他蛋白酶抑制剂(PI)的患者进行比较,以提供治疗48周时有关疗效与安全性的最新信息。
方法在24周的剂量探索期和主要疗效分析后,被随机分入地瑞那韦-利托那韦组的患者继续服药600/100mg2次/d.而对照PI组的患者继续按指定治疗方案进入较长期的开放标记期;所有患者继续接受最佳背景治疗。对在分析时已达到第48周或提前停药的患者进行了评估;地瑞那韦~利托那韦组只纳入了从基线开始就服用600/100mg2次/d的患者。采用意向性治疗分析。POWER2研究(TMC114-C202)在ClinicalTrials.gov注册(NCT00071097)。结果48周时,110例地瑞那韦-利托那韦组患者中有67例(61%)病毒载量较基线下降≥1 log10拷贝/ml,而120例对照PI组患者中仅有18例(15%)(主要终点;反应率差值46%,95%CI35%~57%,P〈0,0001)。根据logisticS/归模型,该模型将分层因素(基线时原发PI突变数、恩夫韦地的使用、基线病毒载量)和研究作为协变量,反应率差值为50%(OR 11.72,95%CI 5.75~23.89)。在地瑞那韦-利托那韦组,如果校正治疗暴露,则不良事件率大都低于或近似于对照组。没有发现意外的安全事件。
结论采用地瑞那韦-利托那韦600/100mg 2次/d加最佳背景治疗的疗效反应大于对照PI。且疗效至少持续48周,尤其在曾治疗HIV患者中具有良好的安全性和耐受性。这一方案扩展了此类患者的治疗选择。 | Bonaventura Claret Nicholas Bellos Jean-Michel Molina David Cooper Jean-Christophe Goffard Adriano Lazzarin Andrej Wohrmann Christine Katlama Timothy Wilkin Richard Haubrich Calvin Cohen Charles Farthing Dushyantha Jayaweera Martin Markowitz Peter Ruane Sabrina Spinosa-Guzman Eric Lefebvre 王介明(译) 李宏建(译) | 2008 | 世界临床医学2008，2，2： | 0 |
| 6 | Single-Atomic Site Catalyst Enhanced Lateral Flow Immunoassay for Point-of-Care Detection of Herbicide显示文摘Point-of-care(POC)detection of herbicides is of great importance due to their impact on the environment and potential risks to human health.Here,we design a single-atomic site catalyst(SASC)with excellent peroxidase-like(POD-like)catalytic activity,which enhances the detection performance of corresponding lateral flow immunoassay(LFIA).The iron single-atomic site catalyst(Fe-SASC)is synthesized from hemin-doped ZIF-8,creating active sites that mimic the Fe active center coordination environment of natural enzyme and their functions.Due to its atomically dispersed iron active sites that result in maximum utilization of active metal atoms,the Fe-SASC exhibits superior POD-like activity,which has great potential to replace its natural counterparts.Also,the catalytic mechanism of Fe-SASC is systematically investigated.Utilizing its outstanding catalytic activity,the Fe-SASC is used as label to construct LFIA(Fe-SASC-LFIA)for herbicide detection.The 2,4-dichlorophenoxyacetic acid(2,4-D)is selected as a target here,since it is a commonly used herbicide as well as a biomarker for herbicide exposure evaluation.A linear detection range of 1-250 ng/mL with a low limit of detection(LOD)of 0.82 ng/mL has been achieved.Meanwhile,excellent specificity and selectivity towards 2,4-D have been obtained.The outstanding detection performance of the Fe-SASC-LFIA has also been demonstrated in the detection of human urine samples,indicating the practicability of this POC detection platform for analyzing the 2,4-D exposure level of a person.We believe this proposed Fe-SASC-LFIA has potential as a portable,rapid,and high-sensitive POC detection strategy for pesticide exposure evaluation. | Zhaoyuan Lyu Shichao Ding Peter Tieu Lingzhe Fang Xin Li Tao Li Xiaoqing Pan Mark H.Engelhard Xiaofan Ruan Dan Du Suiqiong Li Yuehe Lin | 2023 | Research2023，，1： | 0 |
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