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| 1 | Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review显示文摘AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity profile.METHODS A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords 'thioguanine', '6-TG', 'thioguanine', 'inflammatory bowel disease', 'IBD', 'Crohn's disease', 'Ulcerative colitis' and 'effectiveness' in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not performed.RESULTS A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients. | Berrie Meijer Chris JJ Mulder Godefridus J Peters Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 2 | Pancreatic-Type Ribonuclease 1 Gene Duplications in Rat Species显示文摘 | Jean-Yves F. Dubois Peter A. Jekel Patty P.M.F.A. Mulder Anton P. Bussink Fran?ois M. Catzeflis Antonella Carsana Jaap J. Beintema | 2002 | Journal of Molecular Evolution2002，，5： | 1 |
| 3 | Anaerobic oxidation of ammonium is a biologically mediated process 显示文摘 | DRAAF A A MULDER A PETER DE B | 1955 | Appl Environ Microbiol1955，61，4： | 1 |
| 4 | EAU Guidelines on Renal Cell Carcinoma: The 2010 Update显示文摘 | B?rje Ljungberg Nigel C. Cowan Damian C. Hanbury Milan Hora Markus A. Kuczyk Axel S. Merseburger Jean-Jacques Patard Peter F.A. Mulders Ioanel C. Sinescu | 2010 | European Urology2010，，3： | 1 |
| 5 | Dynamics and determinants of energy intensity in the service sector: A cross-country analysis, 1980–2005显示文摘 | Peter Mulder Henri L.F. de Groot Birte Pfeiffer | 2014 | Ecological Economics2014，，： | 1 |
| 6 | Variability of glutathione S - transferase alpha in human liver and plaama 显示文摘 | Mulder TP Court DA Peters WH | 1999 | Clin Chem1999，45，3： | 1 |
| 7 | Structural change and convergence of energy intensity across OECD countries, 1970–2005显示文摘 | Peter Mulder Henri L.F. de Groot | 2012 | Energy Economics2012，，6： | 1 |
| 8 | Explaining slow diffusion of energy-saving technologies a vintage model with returns to diversity and learning-by-using显示文摘 | PETER MULDER HENRI L F DE GROOT MARJAN W HOFKES | 2003 | Resource and Energy Economics2003，25，1： | 1 |
| 9 | Renal Cell Carcinoma Guideline显示文摘 | B?rje Ljungberg Damian C. Hanbury Marcus A. Kuczyk Axel S. Merseburger Peter F.A. Mulders Jean-Jacques Patard Ioanel C. Sinescu | 2007 | European Urology2007，，6： | 1 |
| 10 | Prognostic Value of Renal Vein and Inferior Vena Cava Involvement in Renal Cell Carcinoma显示文摘 | Bernd Wagner Jean-Jacques Patard Arnaud Méjean Karim Bensalah Grégory Verhoest Richard Zigeuner Vincenzo Ficarra Jacques Tostain Peter Mulders Denis Chautard Jean-Luc Descotes Alexandre de la Taille Laurent Salomon Tommaso Prayer-Galetti Luca Cindolo Anto | 2008 | European Urology2008，，2： | 1 |
| 11 | Urinary excretion of glutathione transferases alpha and pi in patients with proteinuria: reflection of the site of tubular injury 显示文摘 | Branten AJ Mulder TP Peters WH | 2000 | Nephron2000，85，2： | 1 |
| 12 | Urinary excretion of glutathione S transferases alpha and pi in patients with proteinuria: reflection of the site of tubular injury 显示文摘 | Branten AJ Mulder TP Peters WH | 2000 | Nephron2000，85，2： | 1 |
| 13 | Anaerobic oxidation of ammonium is abiologieally mediated process 显示文摘 | de Graaf Astrid Avan A mold Mulder de Bruijn Peter | 1995 | Applied Environmental Microbiology1995，61，4： | 1 |
| 14 | Molecular printboards on silicon oxide: Lithographic patterning of cyclodextrin monolayers with multivalent, fluorescent guest molecules 显示文摘 | Mulder A Onclin S Peter M | 2005 | Small2005，1，： | 1 |
| 15 | EAU Guidelines on Renal Cell Carcinoma: The 2010 Update显示文摘 | B?rje Ljungberg Nigel C. Cowan Damian C. Hanbury Milan Hora Markus A. Kuczyk Axel S. Merseburger Jean-Jacques Patard Peter F.A. Mulders Ioanel C. Sinescu | 2010 | European Urology2010，，3： | 1 |
| 16 | Measurement of glutathione S-transferase P1-1 in plasma: pitfalls and significance of screening and follow-up of patients with gastrointestinal carcinoma显示文摘 | Mulder TP Peters WH Wobbes T | 1997 | Cancer1997，80，5： | 1 |
| 17 | EAU Guidelines on Renal Cell Carcinoma: The 2010 Update显示文摘 | B?rje Ljungberg Nigel C. Cowan Damian C. Hanbury Milan Hora Markus A. Kuczyk Axel S. Merseburger Jean-Jacques Patard Peter F.A. Mulders Ioanel C. Sinescu | 2010 | European Urology2010，，3： | 1 |
| 18 | Sequencing of Agents for Metastatic Renal Cell Carcinoma: Can We Customize Therapy?显示文摘 | Guru Sonpavde Toni K. Choueiri Bernard Escudier Vincenzo Ficarra Thomas E. Hutson Peter F. Mulders Jean-Jacques Patard Brian I. Rini Michael Staehler Cora N. Sternberg Christian G. Stief | 2011 | European Urology2011，，2： | 1 |
| 19 | The reverse side of the victory: Flare up of symptoms after discontinuation of sunitinib or sorafenib in renal cell cancer patients. A report of three cases显示文摘 | Ingrid M. E. Desar Sasja F. Mulder Alexander B. Stillebroer Dick-Johan van Spronsen Winette T. A. van der Graaf Peter F. A. Mulders Carla M. L. van Herpen | 2009 | Acta Oncologica2009，，6： | 1 |
| 20 | Dynamics and determinants of energy intensity in the service sector: A cross-country analysis,1980-2005 显示文摘 | Peter Mulder Birte Pfeiffer | 2014 | Ecological Economics2014，100，： | 1 |
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