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| 1 | 心力衰竭患者使用曲美他嗪调节代谢对左室功能和磷酸肌酸/三磷酸腺苷比值的影响显示文摘Aims: The addition of trimetazidine to standard treatment has been shown to improve left ventricular(LV) function in patients with heart failure. The aim of this study is to non-invasively assess, by means of in vivo 31P-magnetic resonance spectroscopy(31P-MRS), the effects of trimetazidine on LV cardiac phosphocreatine and adenosine triphosphate(PCr/ATP) ratio in patients with heart failure. Methods and results: Twelve heart failure patients were randomized in a double-blind, cross-over study to placebo or trimetazidine(20 mg t.i.d.) for two periods of 90 days. At the end of each period, all patients underwent exercise testing, 2D echocardiography, and MRS. New York Heart Association(NYHA) class, ejection fraction(EF), maximal rate-pressure product, and metabolic equivalent system(METS) were evaluated. Relative concentrations of PCr and ATP were determined by cardiac 31P-MRS. On trimetazidine, NYHA class decreased from 3.04±0.26 to 2.45±0.52(P=0.005), whereas EF(34±10 vs. 39±10%, P=0.03) and METS(from 7.44±1.84 to 8.78±2.72, P=0.03) increased. The mean cardiac PCr/ATP ratio was 1.35±0.33 with placebo, but was increased by 33%to 1.80±0.50(P=0.03)with trimetazidine. Conclusion: Trimetazidine improves functional class and LV function in patients with heart failure. These effects are associated to the observed trimetazidi ne-induced increase in the PCr/ATP ratio, indicating preservation of the myocar dial high-energy phosphate levels. | Fragasso G. Perseghin G. De Cobelli F. 苏畅(译) 杜媛(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，9： | 2 |
| 2 | Metabolic defects in lean nondiabetic offspring of NIDDM parents:a cross-sectional study显示文摘 | Perseghin G Ghosh S Gerow K | 1997 | Diabetes1997，46，6： | 1 |
| 3 | Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure显示文摘 | Fragasso G Perseghin G De Cobelli F | 2006 | Eur Heart J2006，27，8： | 1 |
| 4 | l Serum retinolbinding protein-4, leptin, and adiponectin concentrations are related to ectopic fat accumulation显示文摘 | Perseghin G Lattuada G De C et a | 2007 | JClinEndocrinolMetab2007，92，12： | 1 |
| 5 | Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: effect of liver transplantation 显示文摘 | Perseghin G Mazzaferro V Sereni L P | 2000 | Hepatology2000，31，3： | 1 |
| 6 | Serum retinol-binding prqtein-4, leptin, and adiponectln concentrations are related to eetopic fat accu- mulation显示文摘 | Perseghin G Lattuada G De C | 2007 | J Clin Endocrinol Metab2007，92，12： | 1 |
| 7 | Mechanism of free fatty acid- induced insulin resistance in humans显示文摘 | Roden M Price TB Perseghin G | 1996 | J Clin Invest1996，97，12： | 1 |
| 8 | Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver显示文摘 | Perseghin G Lattuada G De Cobelli F | 2008 | Hepatology2008，47，1： | 1 |
| 9 | Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosinetriphosphate ratio in patients with heart failure显示文摘 | Fragassol G Perseghin G De Cobelli F | 2006 | Eur Heart J2006，27，： | 1 |
| 10 | Cellular mechanism of insulin resistance: potential links with inflammation 显示文摘 | Perseghin G Petersen K Shulman G | 2003 | Int J Obes Relat Metab Disord2003，27，3： | 1 |
| 11 | Nonalcoholicfatty liver disease is associated with left ventricular dias-tolic dysfunction in patients with type 2 diabetes 显示文摘 | Bonapace S Perseghin G Molon G | 2012 | Dia-betes Care2012，35，2： | 1 |
| 12 | Mechanism of free fatty acid induced insulin resistance in humans显示文摘 | Roden M Price TB Perseghin G | 1996 | Clin Invest1996，97，： | 1 |
| 13 | Rapid Publication Mechanism of Free Fatty Acid-induced Insulin Resistance in Humans显示文摘 | Roden M Price T B Perseghin G | 1996 | Society1996，97，12： | 1 |
| 14 | Effects of metabolic modulation by trimetazidine on left ventricular function and phos- phocroatine/adenosine triphosphate ratio in patients with heart failure显示文摘 | Fragasso G Perseghin G De Cobelli F | 2006 | Eur Heart J2006，27，8： | 1 |
| 15 | Metabolic defects in lean nondiabetic offspring of NIDDM parent 显示文摘 | Perseghin G Ghosh S Gerow K | 1997 | Diabetes1997，46，： | 1 |
| 16 | Effects of met abolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure显示文摘 | Fragasso G Perseghin G De Cobelli F | 2006 | Fur Heart J2006，27，8： | 1 |
| 17 | Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure 显示文摘 | Fragasso G Perseghin G De Cobelli F | 2006 | Eur Heart J2006，27，8： | 1 |
| 18 | Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure显示文摘 | Fragasso G Perseghin G De Cobelli F | 2006 | Eur Heart J2006，27，2： | 1 |
| 19 | Mechanism of free fatty acid-induced insulin resistance in human显示文摘 | Roden M Price TB Perseghin G | 1996 | J Clin Invest1996，97，： | 1 |
| 20 | Peripheral blood stem cell collection in children with acute leukemia:effectiveness of the DIAVE′ mobilizing regimen显示文摘 | Balduzzi A Perseghin P Dassi M | | 0，，07： | 1 |
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