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| 1 | Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis显示文摘Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma(HCC),but in non-alcoholic fatty liver disease(NAFLD),up to 50%of patients with HCC had no clinical or histological evidence of cirrhosis.It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis,and each patient should be evaluated on a caseby-case basis based on the profile of specific risk factors identified.For HCC screening in NAFLD,a valid precision-based screening is needed.Currently,when evaluating this population of patients,the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program.Hence,the objective of the present study is to review the epidemiology,the pathophysiology,the histopathological aspects,the current recommendations,and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC. | Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral Giovana D P Sartori Livia Villela Nogueira Gustavo Tovo Both Cristiane A Villela-Nogueira Angelo A de Mattos | 2023 | World Journal of Gastroenterology2023，29，2： | 1 |
| 2 | Applicability of Superpave hinder testing protocols to modified hinders 显示文摘 | Bahia HU Perdomo D Turner P | 1997 | Transportation Research Record: Journal of the Transportation Research Board1997，1586，1： | 1 |
| 3 | Physiological chan ges associated with performance of Kentucky bluegrass 11 cultivars during summer stress 显示文摘 | Perdomo P Murphy J A Berkowitz G A | 1996 | HortScience1996，31，7： | 1 |
| 4 | ConcuiTent administration of donepezil HC1 and ketoconazole: assessment of pharmacokinetic changes following single and muhiple doses 显示文摘 | TISEO P J PERDOMO C A FRIEDHOFF L T | 1998 | Br J Clin Pharmacol1998，46，1： | 1 |
| 5 | Physiological changes associated with performance of Kentucky bluegrass cultivars during summer stress 显示文摘 | Perdomo P J Amurphy | 1996 | Hort Science1996，31，7： | 1 |
| 6 | Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells显示文摘 | Rigalli J P Ruiz M L Perdomo V G | 2011 | Toxicology2011，285，12： | 1 |
| 7 | Physiological changes associated with performance of Kentucky bluegrass cultivars dur- ing summer stress显示文摘 | Perdomo P Murphy J A Berkowits G A | 1996 | Hort Sci1996，31，： | 1 |
| 8 | Physiological changes associated with performance of Ke ntucky bluegrass cultivars during summer stress显示文摘 | Perdomo P Murphy J A Berkowitz G A | 1996 | Hort Science1996，31，： | 1 |
| 9 | Physiological changes associated with performance of Kentucky bluegrass cultivars during summer stress显示文摘 | Perdomo P Murphy J A Berkowitz G A | 1996 | Hort Science1996，31，7： | 1 |
| 10 | Ca^(2+)-亚氨二醋酸金属离子亲和色谱法吸附内毒素(英文)显示文摘Endotoxins(also known as lipopolysaccharides(LPS)) are undesirable by-products of recombinant proteins,purified from Escherichia coli.LPS can be considered stable under a wide range of temperature and pH,making their removal one of the most difficult tasks in downstream processes during protein purification.The inherent toxicity of LPS makes their removal an important step for the application of these proteins in several biological assays and for a safe parenteral administration.Immobilized metal affinity chromatography(IMAC) enables the affinity interactions between the metal ions(immobilized on the support through the chelating compound) and the target molecules,thus enabling high-efficiency separation of the target molecules from other components present in a mixture.Affinity chromatography is applied with Ca2+-iminodiacetic acid(IDA) to remove most of the LPS contaminants from the end product(more than90%).In this study,the adsorption of LPS on an IDA-Ca2+ was investigated.The adsorption Freundlich isotherm of LPS-IDA-Ca2+ provides a theoretical basis for LPS removal.It was found that LPS is bound mainly by interactions between the phosphate group in LPS and Ca2+ ligands on the beads.The factors such as pH(4.0 or 5.5) and ionic strength(1.0 mol/L) are essential to obtain effective removal of LPS for contaminant levels between endotoxin' concentration values less than100 EU/mL and 100 000 EU/mL.This new protocol represents a substantial advantage in time,effort,and production costs. | André Moreni LOPES Jorge Sánchez ROMEU Rolando Páez MEIRELES Gabriel Marquez PERERA Rolando Perdomo MORALES Adalberto PESSOA Lourdes Zumalacárregui CáRDENAS | 2012 | 色谱2012，30，11： | 1 |
| 11 | Physiological changes associated with performance of kenruckey bluegrass cultivars during sunnier stress显示文摘 | Perdomo P Munphy J A Berlcovritzg A | 1996 | Hort Sci1996，31，7： | 1 |
| 12 | Physiological changes associated with performance of Kentucky bluegrass cultivars during summer stres显示文摘 | Perdomo P Murphy J A Berkowitz G A | 1996 | Hort science1996，31，7： | 1 |
| 13 | Physiological changes associated with performance of Kentucky bluegrass cultivars during summer stress显示文摘 | Perdomo P Murphy J A Berkowitz G A | 1996 | HortScience1996，31，7： | 1 |
| 14 | Nitrous oxide emissions from an Uruguayan argiudoll under different tillage and rotation treatments 显示文摘 | Perdomo C Irisarri P Ernst O | 2009 | Nutri- ent Cycling in Agroecosystems2009，84，2： | 1 |
| 15 | Pregnane X receptor mediates the induction of P-glycoprotein by spirono- lactone in HepG2 cells显示文摘 | RIGALLI J P RUIZ M L PERDOMO V G | 2011 | Toxicology2011，285，12： | 1 |
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