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| 1 | Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication显示文摘Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the gastrointestinal tract that share clinical and pathological characteristics. The most accredited hypothesis is that both CD and UC result from a deregulated mucosal immune response to normal constituents of the gut microflora. Evidence, however, indicates that the main pathological processes in these two diseases are distinct. In CD, the tissue- damaging inflammatory reaction is driven by activated type 1 helper T-cell (Th1), whereas a humoral response predominates in UC. Consistently, a marked accumulation of macrophages making interleukin (IL)-12, the major Th1-inducing factor, is seen in CD but not in UC mucosa. Preliminary studies also indicate that administration of a monoclonal antibody blocking the IL-12/p40 subunit can be useful to induce and maintain clinical remission in CD patients. Notably, the recently described IL-23 shares the p40 subunit with IL-12, raising the possibility that the clinical benefit of the anti-IL-12/p40 antibody in CD may also be due to the neutralization of IL-23 activity. This review summarizes the current information on the expression and functional role of IL-12 and IL- 12-associated signaling pathways both in patients with CD and experimental models of colitis, thus emphasizing major differences between IL-12 and IL-23 activity on the development of intestinal inflammation. | Ilaria Peluso Francesco Pallone Giovanni Monteleone | 2006 | World Journal of Gastroenterology2006，12，35： | 16 |
| 2 | Cerium,manganese and cerium/manganese ceramic monolithic catalysts.Study of VOCs and PM removal显示文摘Ceramic supported cerium, manganese and cerium-manganese catalysts were prepared by direct impregnation of aqueous precursor, and characterized by scanning electron microscopy(SEM), X-ray diffraction(XRD), Brunauer-Emmett-Teller method(BET), temperature programmed reduction(H_2-TPR), X-ray photoelectron spectroscopy(XPS) acidity measurements and electrical conductivity. The catalytic activity was evaluated for volatile organic compounds(VOC)(ethanol, methyl ethyl ketone and toluene) oxidation. Additionally, catalysts were tested in particulate matter(PM) combustion. The characterization results indicated that Ce was in the form of Ce^(4+) and Ce^(3+), and Mn existed in the form of Mn^(4+) and Mn^(3+) on the surface of the Mn/AC sample and in the form of Mn^(4+) in the Ce/Mn/AC monolith. VOC oxidation results revealed that the Ce/Mn/AC sample showed an excellent performance compared with ceramic supported CeO_2(Ce/AC) and MnO_x(Mn/AC) samples. The PM combustion was also higher on Ce/Mn/AC monoliths. The enhanced catalytic activity was mainly attributed to the Ce and Mn interaction which enhanced the acidity, conductivity and the reducibility of the oxides. | COLMAN-LERNER Esteban PELUSO Miguel Andres SAMBETH Jorge THOMAS Horacio | 2016 | Journal of Rare Earths2016，34，7： | 9 |
| 3 | Diet in neurogenic bowel management:A viewpoint on spinal cord injury显示文摘The aim of this review is to offer dietary advice for individuals with spinal cord injury(SCI)and neurogenic bowel dysfunction.With this in mind,we consider health conditions that are dependent on the level of lesion including skeletal muscle atrophy,autonomic dysreflexia and neurogenic bladder.In addition,SCI is often associated with a sedentary lifestyle,which increases risk for osteoporosis and diseases associated with chronic low-grade inflammation,including cardiovascular and chronic kidney diseases.The Mediterranean diet,along with exercise and dietary supplements,has been suggested as an anti-inflammatory intervention in individuals with SCI.However,individuals with chronic SCI have a daily intake of whole fruit,vegetables and whole grains lower than the recommended dietary allowance for the general population.Some studies have reported an increase in neurogenic bowel dysfunction symptoms after high fiber intake;therefore,this finding could explain the low consumption of plant foods.Low consumption of fibre induces dysbiosis,which is associated with bothendotoxemia and inflammation.Dysbiosis can be reduced by exercise and diet in individuals with SCI.Therefore,to summarize our viewpoint,we developed a Mediterranean diet-based diet and exercise pyramid to integrate nutritional recommendations and exercise guidelines.Nutritional guidelines come from previously suggested recommendations for military veterans with disabilities and individuals with SCI,chronic kidney diseases,chronic pain and irritable bowel syndrome.We also considered the recent exercise guidelines and position stands for adults with SCI to improve muscle strength,flexibility and cardiorespiratory fitness and to obtain cardiometabolic benefits.Finally,dietary advice for Paralympic athletes is suggested. | Marco Bernardi Anna Lucia Fedullo Elisabetta Bernardi Diego Munzi Ilaria Peluso Jonathan Myers Florigio Romano Lista Tommaso Sciarra | 2020 | World Journal of Gastroenterology2020，26，20： | 7 |
| 4 | Chitosan-mediated stimulation of macrophage function显示文摘 | Peluso G Petillo O Ranieri M | 1994 | Biomaterials1994，15，15： | 2 |
| 5 | A new selfexpandable nitinol stem for the treatment of wide-neck aneurysms:initial clinical experience显示文摘 | Peluso JP Van Rooij WJ Sluzewski M | 2008 | AJNR2008，29，： | 1 |
| 6 | Physical Activity and Mental Health:the Association between Exercise and Mood显示文摘 | Peluso MAM Andrade LHSG | 2005 | Clinics2005，60，： | 1 |
| 7 | XRCC1,XRCC3,XPD gene polymorphisms,smoking and(32)P-DNA adducts in a sample of healthy subjects显示文摘 | Matullo G Palli D Peluso M | 2001 | Carcinogenesis2001，22，9： | 1 |
| 8 | Carnitine protects the molecular chaperone activity of lens alpha-crystallin and decreases the post-translational protein modifications induced by oxidative stress显示文摘 | Peluso G Petillo O Barbarisi A | 2001 | FASEBJ2001，15，： | 1 |
| 9 | Diffuse hypertriehosis during treatment with 5% topical minoxidil 显示文摘 | Peluso AM Misciali C Vincenzi C | 1997 | Br J Dermatol1997，136，1： | 1 |
| 10 | Identification and charac- terization of microRNAs expressed in the mouse eye显示文摘 | Karali M Peluso I Marigo V Banff S | 2007 | Invest Ophthalmol Vis Sci2007，48，2： | 1 |
| 11 | Treatment of HIV in the CNS:effects of antiretrovi- ral therapy and the promise of non-antiretroviral therapeutics 显示文摘 | Peluso M J Spudieh S | 2014 | Curt HIV/AIDS Rep2014，11，3： | 1 |
| 12 | Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB显示文摘 | Medina DL Di Paola S Peluso I | 2015 | Nat Cell Biol2015，17，3： | 1 |
| 13 | XRCC1, XRCC3, XPD gene polymorphisms, smoking and ^32p-DNA adducts in a sample of healthy subjeets显示文摘 | Matullo G Palli D Peluso M | 2001 | Carcinogenesis2001，22，： | 1 |
| 14 | Overview: a diffusion-multiple approach for mapping phase diagrams, hardness, and elastic modulus 显示文摘 | ZHAO J-C JACKSON M R PELUSO L A | 2002 | JOM2002，54，7： | 1 |
| 15 | Right atrial size and function assessed with three-dimensional and speckle-tracking echocardiography in 200 healthy volunteers显示文摘 | Peluso D Badano LP Muraru D | 2013 | Eur Heart J Cardiovasc Imaging2013，14，11： | 1 |
| 16 | Helicobacter pylori regulates iNOS promoter by histone modifications in human gastric epithelial cells显示文摘 | Tiziana Angrisano Francesca Lembo Silvia Peluso Simona Keller Lorenzo Chiariotti Raffaela Pero | 2012 | Medical Microbiology and Immunology2012，，： | 1 |
| 17 | High-mobility group A (HMGA) pro- teins and breast cancer显示文摘 | Peluso S Chiappetta G | 2010 | Breast Care (Basel)2010，5，2： | 1 |
| 18 | Digital Models:An Introduction显示文摘 | Matthew J Peluso Stuart D | 2004 | Semin Orthod2004，10，3： | 1 |
| 19 | Isolation, characterization, and chondrogenic potential of human bone marrow-derived multipotential stromal cells显示文摘 | Majumdar MK Banks V Peluso DP | 2000 | J Cell Physiol2000，185，1： | 1 |
| 20 | The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway显示文摘 | Sherri Smith Jennifer Hoyt Nigel Whitebread Joseph Manna Marisa Peluso Kerrie Faia Veronica Campbell Martin Tremblay Somarajan Nair Michael Grogan Alfredo Castro Matthew Campbell Jeanne Ferguson Brendan Arsenault Jylle Nevejans Bennett Carter John Lee Joi | 2013 | Xenobiotica2013，，10： | 1 |
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