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| 1 | Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update显示文摘morbidity and mortality for healthcare systems worldwide.It imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment crucial.This review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent pathway.The dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver injuries.Activation of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy hepatocytes.Therefore,liver function is reduced due to the severely advanced disease.Selective inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in vivo.While the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and cancer.Targeted blocking of some of the basic components of the Wnt path-way is a therapeutic approach.These include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-specific transcription factor(TCF)system as well as Wnt inhibitory factor 1(WIF1)and miR-17-5p using pinostilbene hydrate(PSH).Significant progress has been made in inhibiting Wnt and thus stopping the progression of liver fibrosis by diminishing key components for its action.Comprehending the role of the Wnt signaling pathway in liver fibrosis may lead to discovery of novel targets in liver fibrosis therapeutic strategies’development. | Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 2 | Comparative analysis of genetic similarity among maize inbred lines detected by RFLPs, RAPDs, SSRs and AFLPs 显示文摘 | Pejic L Ajmone-Marsan P Morgante M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 3 | Familial hypercholesterolemia 显示文摘 | Pejic R N | 2014 | The Ochsner Journal2014，14，4： | 1 |
| 4 | Comparative analysis of genetic similarity among maize inbred lines detected by RALPs, RAPDs, SSRs, and AFLPs 显示文摘 | Pejic I Ajmone-Marsan P Morgante M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 5 | Comparative analysis of genetic similarity among maize inbred lines detected by RFLPs, RAPDs, SSRs and AFLPs 显示文摘 | Pejic I Ajmone-Marsan P Morgante M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 6 | Immunohistochemical ex-pression of nestin in rhabdomyosarcoma : implications for clinicopa-thology and patient outcome显示文摘 | Glumac S Pejic S Kovacevic R al | 2015 | Genet Mol Res2015，14，14： | 1 |
| 7 | Comparative analysis of genetic similarityamong maize inbred lines detected by RFLPs,RAPDs,SSRs and AFLPs显示文摘 | Pejic I Ajmone-Marsan P Morgante M | 1998 | Theoretical and Applied Genetics1998，97，： | 1 |
| 8 | Comparative analysis of genetic similarity among maize inbred lines detected by RFLPs, RAPD, SSRs and AFLPs显示文摘 | Pejic L Ajmone Marson P Morgante M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 9 | Determination of CI-,Br-,I-,Mn2+,malonic acid and quercetin by perturbation of a non-equilibrium stationary state in the Bray-Liebhafsky reaction显示文摘 | Vukojevic V.B Pejic N.D Stanisavljev D.R | | 0，，： | 1 |
| 10 | Direct Spectrophotometric Determination of Quercetin in the Presense of Ascorbie Acid显示文摘 | Pejic N Kuntic V Vujic Z | 2004 | It Farmaco2004，59，1： | 1 |
| 11 | Comparative analysis of genetic similarity among maize inbred lines detected by RFLPs, RAPDs, SSRs and AFLPs显示文摘 | Pejic I Ajmone-Marsan P Morgante M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 12 | Using Laplacian eigenvalues and eigenvectors in the analysis of frequency assignment problem显示文摘 | HEUVEL J V PEJIC S | 2001 | Annals of Operations Research2001，107，： | 1 |
| 13 | Comparative analysis of genetic similarity among maize inbred lines detected by RFLPs,RAPDs,SSRs and AFLPs显示文摘 | Pejic I Ajmone-Marsan P Morgante M Kozumplik V Castiglioni P Taramino G Motto M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 14 | Comparative analysis of genetic similarity among maize inbred lines detected by RFLPs, RAPDs, SSRs, and AFLPs显示文摘 | Pejic I Ajmone-Marsan P Morgante M | 1998 | Theoretical & Applied Genetics1998，97，8： | 1 |
| 15 | Comparative analysis of genetic similarity among maize inbred lines detected by RFLPs, RAPDs, SSRs, and AFLPs 显示文摘 | Pejic I Ajmone Marsan P Morgante M | 1998 | Theor Appl Genet1998，98，： | 1 |
| 16 | Alterations in Hippocampal Antioxidant Enzyme Activities and Sympatho-Adrenomedullary System of Rats in Response to Different Stress Models显示文摘 | Pajovic S B Pejic S Stojiljkovic V | 2005 | Physiol Res2005，，： | 1 |
| 17 | Direct spectrophotometric determination of quercetin in the presense of ascorbic acid显示文摘 | Pejic N Kuntic V Vujic Z | 2004 | Il Farmaco2004，59，1： | 1 |
| 18 | Comparative analysis d genetic similarity among maize inbred lines detected by RFLPs, RAPDs, SSP, s and AFLPs显示文摘 | Pejic IAjmone Marsan P Morgente M | 1998 | Theor Appl C enet1998，98，： | 1 |
| 19 | Comparative analysis of genetic similarity among maize lines detected by RFLPs,RAPDs,SSRs and AFLPs显示文摘 | PEJIC I AJMONE MARSAN P MORGANTE M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 20 | Hypertriglyceridemia 显示文摘 | Pejic R N Lee D T | 2006 | J Am Board Faro Med2006，19，3： | 1 |
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