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19篇 您的检索式：作者名="Peirone"

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		题名	作者	年代	出处	被引量
	1	Delivery of recombinant gene product to cannies with nonautologous microencapsulated cells 显示文摘	Delaney K Kwiecin J	1998	Hum Gene Ther1998，9，2：	1
	2	Radiofrequency perforation and conventional needle percutaneous transseptal left heart access: pathological features显示文摘	Veldtman GR Wilson GJ Peirone A	2005	Catheter Cardiovasc Inter2005，65，4：	1
	3	Clinical pharmacokinetics profile of ivermectin 1% cream after dermal applications on the face显示文摘AIM: To investigate the pharmacokinetics profile of Ivermectin 1% cream after topical treatment in patients with papulopustular rosacea(PPR).METHODS: Ivermectin 1% cream is a new, effective, and safe treatment for PPR. The human pharmacokinetic(PK) profile of ivermectin and its circulating metabolites were assessed following topical application of ivermectin 1% cream to the face. Clinical PK assessments were conducted after 4 wk of treatment using healthy volunteers and PPR subjects. Additionally, PK sampling was conducted up to 1 year of treatment in clinical phase 3 studies. Plasma concentrations of ivermectin and ivermectin metabolites were determined using high-performance liquid chromatography with fluorescence detection after a specific derivation to increase sensitivity.RESULTS: Systemic exposure to ivermectin was quantifiable at low levels in healthy and moderate to severe PPR subjects following the first topical application of ivermectin 1% cream(mean Cmax of 0.5 ± 0.2 ng/mL and 0.7 ± 0.5 ng/mL in healthy volunteers and PPR subjects, respectively). Ivermectin plasma levels reached a plateau after 2 wk of repeated topical application, indicating that steady-state concentrations had been reached. No further ivermectin plasma accumulation was observed during the long-term clinical studies that investigated ivermectin treatment up to 1 year. Investigation of ivermectin metabolites indicated that 2 circulating metabolites represented more than 10% of parent drug systemic exposure at steady state. Repeated topical application of ivermectin 1% cream resulted in lower systemic exposure levels when compared with orally administered ivermectin, suggesting limited transdermal absorption of ivermectin. Topically applied ivermectin is cleared from the plasma slowly(with a prolonged plasma half-life when compared to the oral route).CONCLUSION: Applications of ivermectin 1% cream result in low systemic exposure levels. Steady–state conditions are achieved by 2 wk without further accumulation under chronic treatment.	Khaled Benkali Fran?ois Rony Michael Graeber Jean Jacovella Jean-Paul Chappuis Marie-Helene Peirone Michel Poncet Stéphane Delage Ronan Bouer Nathalie Wagner	2016	World Journal of Dermatology2016，5，1：	1
	4	Use of animplantable loop recorder in the evaluation of children with congenital heart diease显示文摘	SANATANI S PEIRONE A CHIU C	2002	Am Heart J2002，143，：	1
	5	Cryo -Analgesia: uhrastuctural study on cryolytie lesion of scatic nerve in rat and rabbit显示文摘	Fasano VA Peirone SM Zeme S	1987	Acta Neurochir Suppl (Wien)1987，39，：	1
	6	TNF-alpha,TGF-beta2 and IL-1 beta levels in gingival and peri-implant cmvicularfluid before and after de novo plaque accumulation显示文摘	Sehierano G Peirone G Brusco P	2008	J Clin Periodontol2008，35，6：	1
	7	Cytokines and growth factors involved in the osseointegration of oral titanium implants positioned using piezoelectric bone surgery versus a drill technique: a pilot study in minipigs显示文摘	Preti G Martinasso G Peirone B	2007	J Periodontal2007，78，4：	1
	8	Use of an implantable loop recorder in the evaluation of children with congenital heart disease显示文摘	Sanatani S Peirone A Chiu C	2002	Am Heart J2002，143，2：	1
	9	TNF-alpha,TGF-beta2 andIL-l beta levels in gingival and peri-implant cravieu-larlluid beforeand after de novo plaque accumulation显示文摘	Sehierano G Peirone G Brmeo P	2008	Clin Periodontol2008，35，6：	1
	10	Cytokines and growth factors involved in the osseointegration of oral titanium implants positioned using piezoelectric bone surgery versus a drill technique: a pilot study in minipigs显示文摘	Preti G Martinasso G Peirone B	2007	J Periodontol2007，78，4：	1
	11	Ultrastructural studies on calcitonin gene-related peptide-, tachykinins- and somatostatin-immunoreactive neurones in rat dorsal root ganglia: Evidence for the colocalization of different peptides in single secretory granules显示文摘	Adalberto Merighi Professor Julia M. Polak Sally J. Gibson Sergio Gulbenkian Karen L. Valentino Saverio M. Peirone	1988	Cell and Tissue Research1988，，1：	1
	12	Encapsulation of various recombinant mammalian cell types in different alginate microeapsules显示文摘	Peirone M Ross CJD Hortelano G		0，，04：	1
	13	Bncapsulation of various recombinant mammalian cell types in different alginate microcapsules 显示文摘	Peirone M Ross C J D Horteland G	1998	J Biomed Mater Res1998，42，：	1
	14	Percutaneous ultrasound-guided steuting of the atrial sep- turn in fetal sheep 显示文摘	Schmidt M Jaeggi E Ryan G Hyldebrandt J Lilly J Peirone A	2008	Ultrasound Obstet Gynecol2008，32，7：	1
	15	Cryoanalgesi Ultrastnctural study on cryolytic lesion of sciatic nerve in rat and rabbit显示文摘	Fasano VA Peirone SM Zeme S	1987	Acta Neurochir Suppl(Wien)1987，39，：	1
	16	Cytokines and growth factors involved in the osseointegration of oral titanium implants positioned using piezoelectric bone surgery versus a drill technique: a pilot study in minipigs显示文摘	Preti G Martinasso G Peirone B	2007	J Periodontol2007，78，4：	1
	17	Encapsulation of various recombinant mammalian cell types in different alginate microcapsules 显示文摘	Peirone M Ross CJ Hortelano G	1998	Biomed mater Res1998，42，4：	1
	18	Encapsulation of various recombinant mammalian cell types in different alginate microcapsules显示文摘	Ross CJ Hortelano G	1998	J Biomed Mater Res1998，42，：	1
	19	Cytokines and growth factors involved in the osseointegration of oral titanium implants positioned using piezoelectric bone surgery versus a drill technique:a pilot study in minipigs显示文摘	Preti G Martinasso G Peirone B		0，，04：	1

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