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| 1 | 趋化因子受体CXCR4的结构与功能显示文摘目的 认识趋化因子受体CXCR4之结构与功能的关系。方法 分别建立野生型趋化因子受体CXCR4及CXCR2、5个CXCR4/CXCR2嵌合受体和 2个CXCR4突变受体的CHO稳定表达细胞株 ,以配体 -受体结合试验、细胞微生理监测术、体外细胞 -细胞融合实验为手段观察各变异受体与重组人SDF 1β的结合能力、在受刺激后的信号转导能力、以及作为HIV 1辅助受体的能力。结果 有 4个变异受体 (2 444a ,444 2 ,42 2 2 ,CXCR4 Tr)保持了程度不同的与SDF 1β的结合能力 ,其中 2个 (2 444a ,CXCR4 Tr)保留了程度不同的信号转导能力 ;除 1个变异受体 (42 2 2 )外 ,其它变异受体都程度不同的具有辅助受体功能。结论 CXCR4以多个结构区域参与与SDF 1β的相互作用。其N端胞外区足以具有与SDF 1β的高亲和性结合能力。第三环链对CXCR4的结合能力也有其特定的贡献。CXCR4的信号传导不仅需要保守结构DRY盒 ,而且还需要贯穿整个分子的 7个跨膜区域在受配体刺激后形成并维持一定的构象。CXCR4的辅助受体功能结构域与配体结合功能结构域间存在交叉重叠。 | 郑红 Stephen C Peiper 朱锡华 | 2001 | 第三军医大学学报2001，23，2： | 7 |
| 2 | Activation of Rho and Rho- associated kinase by GPR54 and KISS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis显示文摘 | Navenot J M Fujii N Peiper S C | 2009 | Mol Pharmacol2009，75，6： | 1 |
| 3 | KISS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor sig- naling to Akt, tumor necrosis factor family ligand expression, and apoptosis 显示文摘 | Navenot J M Fujii N Peiper S C | 2009 | Mol Pharmacol2009，75，5： | 1 |
| 4 | The relationship between job strain,workplace diastolic blood pressure,and left ventricular mass index显示文摘 | Schnall PL Peiper C Schwartz JE | 1990 | JAMA1990，263，： | 1 |
| 5 | Unwelcomed guests with master keys: How HIV uses chemokine receptors for cellular entry显示文摘 | Doms R W Peiper S C | 1997 | Virology1997，235，2： | 1 |
| 6 | Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors 显示文摘 | Stephen C Peiper MD Barry Evans | 2008 | Human Pathology2008，39，7： | 1 |
| 7 | Schumpelick V Electrophysiological and mechanical activity of the upper gastrointestinal tract after ducdenoplasty or segmental resection of benign gastric outled stenosis显示文摘 | Peiper C Titkova SM Polivoda M | 2000 | Dig Dis Sci2000，45，： | 1 |
| 8 | Re-excision of soft tissue sarco- ma after inadequate initial operation ( Br J Surg 1995 ; 82 : 278-9) 显示文摘 | Peiper M Zornig C Schroder S | 2001 | BrJSurg2001，88，10： | 1 |
| 9 | Is there a risk of infertil- ity after inguinal mesh repair? Experimental studies in the pig and the rabbit显示文摘 | Peiper C Junge K Klinge U | 2006 | Hernia2006，10，1： | 1 |
| 10 | The influence of inguinal mesh repair on the spermatic cord: a pilot study in the rabbit 显示文摘 | Peiper C Junge K Klinge U | 2005 | J Invest Surg2005，18，5： | 1 |
| 11 | Molecular cloning,expression,and chromosomal location of a human gene encoding the cd33 myeloid differentiation antigen显示文摘 | Peiper S C Ashmun R A Look A T | 1988 | Blood1988，72，： | 1 |
| 12 | Do insulin- like growth factor associated proteins qualify as a tumor marker? Results of a prospective study in 163 cancer patients显示文摘 | Matuschek C Rudoy M Peiper M | 2011 | Eur J Med Res2011，16，10： | 1 |
| 13 | Histopathology and Clinical out come of NFl - associated Vs sporadic Malignant peripher- al nerve sheath tumor 显示文摘 | Hagel C Zils U Peiper M et aI | 2007 | Neurooncol2007，82，2： | 1 |
| 14 | Laparoskopische sple -nektomie显示文摘 | Zomig C Emmennann A Peiper M | 1993 | Chirurg1993，64，： | 1 |
| 15 | Eversion endarterectomy versus open thromboendarterectomy and patch plasty for the treatment of internal carotid artery stenosis显示文摘 | Peiper C Nowack J Ktenidis K | | 0，，： | 1 |
| 16 | Electrophysiological and mechanial actvity of the upper gastrointestinal tract after ducdeno- plasty or segmental resection of benign gastric outlet stenosis 显示文摘 | Peiper C Titkova SM Polivoda M | 2000 | Pig Dis Sci2000，45，3： | 1 |
| 17 | Histopathology and clini- cal outcomeof NFl-associated Vs sporadic malignant periph- eral never sheath tumor 显示文摘 | Hagel C Zils U Peiper M | 2007 | Neurooncol2007，82，2： | 1 |
| 18 | Primary sarcoma of the liver in adults显示文摘 | Peiper MRogiers XZornig C | 1994 | Langenbecks Arch Chir1994，379，6： | 1 |
| 19 | Schumpelick V Electrop- hysiological and mechanical activity of the upper gastrointestinal tract after ducdenoplasty or segmental resection of benign gastric outled stenosis显示文摘 | Peiper C Titkova SM Polivoda M | 2000 | Dig Dis Sci2000，45，3： | 1 |
| 20 | Local versus general anesthesia for Shouldice repair of the inguinal hernia显示文摘 | Peiper C | | 0，，： | 1 |
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