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| 1 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 2 | Effect of edible coating and gamma irradiation on inhibition of mould growth and quality retention of strawberry during refrigerated storage显示文摘 | Peerzada R Hussain Mohd A Dar Ali M Wani | 2012 | International Journal of Food Science and Technology2012，47，11： | 1 |
| 3 | Metals in oysters from the arnhem land coast, Northern Territory, Australia显示文摘 | Peerzada N Ddiekinson C | 1989 | Marine Pollution Bulletin1989，20，3： | 1 |
| 4 | Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin显示文摘 | Sheikh A. Tasduq Kaiser Peerzada Supriya Koul Rinku Bhat Rakesh K. Johri | 2005 | Hepatology Research2005，，： | 1 |
| 5 | Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChiP-Chip显示文摘 | Hoemme C Peerzada A Behre G | | 0，，05： | 1 |
| 6 | Adrenal insufficiency from bilateral adrenal hemorrhage after knee replacement surgrey 显示文摘 | Cozzolino D Peerzada J Heaney JA | 1997 | Urology1997，50，： | 1 |
| 7 | Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis 显示文摘 | Costenbader KH Kim DJ Peerzada J | 2004 | Arthri- tis Rheum2004，50，3： | 1 |
| 8 | Adrenal insufficiency from bilateral adrenal hemorrhage after knee replacement surgrey显示文摘 | Cozzolino D Peerzada J Heaney JA | 1997 | Urology1997，50，1： | 1 |
| 9 | Heavy metal concentration in oysters from Darwin Harbour显示文摘 | PEERZADA N DICKINSON C | 1998 | Mar Pollut Bull1998，19，4： | 1 |
| 10 | Biochemical mani festations of anti tuberculosis drugs induced hepatotoxici ty and the effect of silymarin显示文摘 | Tasduq SA Peerzada K Koul S | 2005 | Hepatol Res2005，31，2： | 1 |
| 11 | A review on developments in dyeing cotton fabrics with re- active dyesfor reducing effluent pollution 显示文摘 | Khatri A Peerzada M H Mohsin M | 2015 | Journal of Cleaner Production2015，87，6： | 1 |
| 12 | Metal in oysters from the Arnhem Land Coast, Northern Territory, Australia显示文摘 | DDICKINSON C | 1989 | Marine Pollution Bulletin1989，20，3： | 1 |
| 13 | Pulmonary toxicities of biolog-ics:a review显示文摘 | Peerzada MM Spiro TP Daw HA | | 0，，02： | 1 |
| 14 | Pulmonary toxicities of biolog-ics:a review显示文摘 | Peerzada MM Spiro TP Daw HA | | 0，，02： | 1 |
| 15 | Vitamin C and elemental composition of some bush fruits 显示文摘 | PEERZADA N RENAUD S RYAN P | 1990 | Plant Nutrition1990，13，： | 1 |
| 16 | Argemone mexicana extract alleviates gastrointestinal disorders by stimulating muscarinic receptors and blocking voltage-gated L-type calcium channels显示文摘Objective:To investigate the pharmacological potential of Argemone mexicana in treating constipation and emesis by using in vitro and in vivo models.Methods:The spasmogenic and spasmolytic effects were evaluated on isolated rabbit jejunum fragments loaded in a tissue organ bath.The response was recorded with an isotonic transducer attached with Power Lab Data Acquisition System.The laxative and antiemetic activities were assessed in BALB-c mice and poultry chicks challenged with carbamylcholine and copper sulphate stimulated emesis,respectively.Results:The total phenolic and total flavonoids contents of the extract were(267.75±5.77)mg GAE/g and(73.86±6.01)mg QE/g,respectively.Argemone mexicana extract exerted spasmogenic effect on isolated rabbit jejunum segments with an EC_(50)value of 0.016 mg/m L,which was blocked by atropine(0.3μM).Argemone mexicana extract exerted spasmolytic effect in atropine treated jejunum fragments with an EC_(50)value of 2.185 mg/mL.Furthermore,Argemone mexicana extract relaxed potassium(80 mM)-induced contractions(EC_(50):9.07 mg/mL),similar to a standard drug verapamil.The calcium channel blocker activity was confirmed by a rightward shift of concentration-response curve of calcium in the presence of Argemone mexicana extract(1-5 mg/mL)and verapamil(0.1-1μM).In addition,the extract increased the distance travelled by a charcoal in the gastrointestinal tract and exhibited antiemetic effect on copper sulphate induced emesis in chicks.Conclusions:Argemone mexicana shows cholinergic agonist and calcium channel blocker activities,as well as antiemetic effect.It may be used as a potential agent for treating gastrointestinal disorders. | Rabia Iqbal Irfan Hamid Khalid Hussain Janbaz Muhammad Furqan Akhtar Ammara Saleem Ali Sharif Sohaib Peerzada Bushra Akhtar Kashif Sohail Sajid Ali | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，5： | 0 |
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