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168篇 您的检索式：作者名="Pearson V"

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	题名	作者	年代	出处	被引量
1	Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.	Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels	2010	World Journal of Gastroenterology2010，16，6：	11
2	Evidence for two rhabdoviruses in taro ( Colocasia esculenta) in the Pacific region显示文摘	Pearson M N Jackson G V H Saelea J	1999	Austral Plant Pathol1999，28，3：	2
3	Concrete penetration by eroding projectiles: experiments and analysis 显示文摘	Gold V M Vrasis G C Pearson J C	1996	Journal of Engineering Mechanics1996，122，2：	1
4	Distribution of prolactin receptor immunoreactivity in ovine skin and changes during the wool follicle growth cycle 显示文摘	Choy V J Nixon A J Pearson A J	1997	Journal of Endocrinology1997，155，：	1
5	Stigma and expressed emotion: a study of people with schizophrenia and their family members in China 显示文摘	Phillips MR Pearson V Li F	2002	Br J Psychiatry2002，181，：	1
6	Stigma and their family members in China显示文摘	Phillips MR Pearson V Li F	2002	Br J Psychiatr2002，181，：	1
7	myostatin propetide and the follistatin - related gene are inhibitory binding proteins of myo- statin in normal serum 显示文摘	HILL J J DAVIES M V PEARSON	2002	J Biol Chem2002，277，40：	1
8	Degeneration of cholinergic neurons in the basal nucleus following kainic or N-methyl-D-aspanic acid application to the cerebral cortex in the rat显示文摘	Sofroniew M V Pearson R C	1985	Brain Res1985，339，1：	1
9	Scaling properties inlandscape patterns:New Zealand experience显示文摘	NIKORA V I PEARSON C P SHANKAR U	1999	Landscape Ecology1999，14，1：	1
10	Prevalence of suicidality during pregnancy and the postpartum显示文摘	Lindahl V Pearson JL Colpe L	2005	Arch Womens Ment Health2005，8，2：	1
11	Executive summaru显示文摘	Pearson T A Fuster V	1996	JACC1996，27，5：	1
12	Executive summary显示文摘	Pearson TA Fuster V	1996	JACC1996，27，5：	1
13	Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS显示文摘	Lin Z Pearson C Chinchilli V	2000	Clin Genet2000，58，：	1
14	Constitutive models for concrete penetration analysis显示文摘	Gold V M Vrasis G C Pearson J C	1996	Journal of Engineering Mechanics1996，122，3：	1
15	Barriers to progress in urinary incontinence:achieving quality assessments显示文摘	PEARSON V HABSCOM J	1998	Geriatric Nersing1998，19，2：	1
16	The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum显示文摘	Hill J J Davies M V Pearson A A	2002	Biol Chem2002，277，43：	1
17	Antibody and T cell respons- es of patients with adenocarcinoma immunized with mannan- MUCI fusion protein显示文摘	Karanikas V Hwang LA Pearson J	1997	J Clin Invest1997，100，11：	1
18	Arm edema in breast cancer patients显示文摘	ERICKSON V S PEARSON M L GANZ P A	2001	J Natt Cancer Inst2001，93，2：	1
19	Intermittent fasting and caloriction amehorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease显示文摘	Halagappa V K Guo Z Pearson M	2007	Neurobiol Dis2007，26，1：	1
20	Concrete Penetration by Eroding Projectiles Experiments and Analysis 显示文摘	GOLD V M VRADIS G C PEARSON J C	1996	ASCE J Eng Mech1996，122，2：	1

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