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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Perineural invasion in adenoid cystic carcinoma:Its causation /promotion by brain-derived neurotrophic factor显示文摘 | Kowalski P J Paulino A F | 2002 | Hum Pathol2002，33，9： | 1 |
| 3 | Domain-selective reactivity of hydroquinone-derived adlayers at basal pt (hkl) single-crystal electrodes 显示文摘 | MARGARITA R L ANTONIO R ENRIQUE H PAULINO T JUAN M F ANTONIO A AMALDO C J | 2009 | Langmuir2009，25，10： | 1 |
| 4 | Novel adsorbent based on slilkworm chrysalides for removal of heavy metals from wastewaters 显示文摘 | Paulino A T Minasse F A S Guilherme M R | 2006 | Journal of Colloid and Interface Science2006，301，： | 1 |
| 5 | Levels of sup-plementation for grazing beef heifers 显示文摘 | Cabral C H A Paulino M F Detmann E | 2014 | Asian-AustralasianJournal of Animal Sciences’2014，27，6： | 1 |
| 6 | Glut-1 is preferen- tially expressed in atypical endometrial hyperplasia and endometrial adenocarcinoma显示文摘 | Nshton-Sager A Amanda M D Paulino A F | 2006 | Appl Immunohistochem Mol Morphol2006，14，2： | 1 |
| 7 | Supplementation ofsuckling beef calves with different levels of crude protein ontropica] pasture显示文摘 | Lopes S A Paulino M F Detmann E | 2014 | Tropical Animal Health and Production2014，46，2： | 1 |
| 8 | Glut-1 is preferential- ly expressed in atypical endometrial hyperplasia and endometrial adenovarcinoma 显示文摘 | Ashton S A Paulino A F Afify A M | 2008 | Oncol Rep2008，19，1： | 1 |
| 9 | Glut-1 is preferentially expressed in atypical endometrial hyperplasia and endometrial adenovarcinoma显示文摘 | Ashton S A Paulino A F Afify A M | 2008 | Oncol Rep2008，19，1： | 1 |
| 10 | Mode I fracture of adhesive joints using tailored cohesive zone models显示文摘 | Alfano M Furgiuele F Leonardi A Maletta C Paulino GH | 2009 | International Journal of Fracture2009，157，1： | 1 |
| 11 | Epithelial tumors of the lacrimal glands:a clinicopathologic study显示文摘 | Paulino A F G Huvos A G | 1999 | Ann Diagn Pathol1999，3，4： | 1 |
| 12 | Rhabdomyosarcoma 显示文摘 | Paulino A C Okcu M F | 2008 | Curt Probl Cancer2008，32，1： | 1 |
| 13 | Novel adsorbent based on silkworm chrysalides for removal of heavy met- als from wastewaters 显示文摘 | PAULINO A T MINASSE F A GUILHERME M R | 2006 | Journal of Colloid & Interface Science2006，301，2： | 1 |
| 14 | Rhabdomyosarcoma显示文摘 | Paulino A C Okcu M F | 2008 | Curr Probl Cancer2008，32，1： | 1 |
| 15 | Performance and nutritional evaluation of beef cattle raised on pasture,castrated at different ages,with and without supplementation显示文摘 | Rocha A A Paulino M F Fernandes H J | 2012 | Revista Brasileira de Zootecnia2012，41，4： | 1 |
| 16 | Hybrid carcinoma of the salivary gland: salivary duct adeno-carcinoma adenoid cystic carcinoma显示文摘 | Snyder M L Paulino A F | 1999 | Histopathology1999，35，4： | 1 |
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