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| 1 | Molecularly targeted therapy for advanced hepatocellular carcinoma-a drug development crisis?显示文摘Hepatocellular carcinoma is the fastest growing cause of cancer related death globally. Sorafenib,a multitargeted kinase inhibitor,is the only drug proven to improve outcomes in patients with advanced disease offering modest survival benefit. Although comprehensive genomic mapping has improved understanding of the genetic aberrations in hepatocellular cancer(HCC),this knowledge has not yet impacted clinical care. The last few years have seen the failure of several first and second line phase Ⅲ clinical trials of novel molecularly targeted therapies,warranting a change in the way new therapies are investigated in HCC. Potential reasons for these failures include clinical and molecular heterogeneity,trial design and a lack of biomarkers. This review discusses the current crisis in HCC drug development and how we should learn from recent trial failures to develop a more effective personalised treatment paradigm for patients with HCC. | Kiruthikah Thillai Paul Ross Debashis Sarker | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 9 |
| 2 | Local Ablative Therapy of Oligoprogressive Disease Prolongs Disease Control by Tyrosine Kinase Inhibitors in Oncogene-Addicted Non–Small-Cell Lung Cancer显示文摘 | Andrew J. Weickhardt Benjamin Scheier Joseph Malachy Burke Gregory Gan Xian Lu Paul A. Bunn Dara L. Aisner Laurie E. Gaspar Brian D. Kavanagh Robert C. Doebele D. Ross Camidge | 2012 | Journal of Thoracic Oncology2012，，12： | 3 |
| 3 | Oxidized Phospholipid Species Promote in Vivo Differential Cx43 Phosphorylation and Vascular Smooth Muscle Cell Proliferation显示文摘 | Scott R. Johnstone Jeremy Ross Michael J. Rizzo Adam C. Straub Paul D. Lampe Norbert Leitinger Brant E. Isakson | 2009 | The American Journal of Pathology2009，，2： | 1 |
| 4 | Laparoscopic Nissen Fundoplication ameliorates symptoms of reflux, especially for Patients with very abnormal DeMeester scores 显示文摘 | Ross SB Villadolid D Paul H | 2008 | Am Surg2008，74，7： | 1 |
| 5 | Brain metabolite alterations and cognitive dysfunction in early Huntington’s disease显示文摘 | Paul G. Unschuld Richard A. E. Edden Aaron Carass Xinyang Liu Megan Shanahan Xin Wang Kenichi Oishi Jason Brandt Susan S. Bassett Graham W. Redgrave Russell L. Margolis Peter C. M. van Zijl Peter B. Barker Christopher A. Ross | 2012 | Mov Disord2012，，7： | 1 |
| 6 | Antibiotics: structure, biosynthesis and mode of action显示文摘 | MCAULIFFE O PAUL ROSS R C | 2001 | Microbiology Reviews2001，25，： | 1 |
| 7 | Preparation of nitramine-nitrates by ring-opening nitration of aziridines by dinitrogen pentoxide(N2O5) 显示文摘 | Golding Peter Ross W Millar Norman C Paul | 1993 | Tetrahedron1993，49，32： | 1 |
| 8 | Toxin release in response to oxidative stress and programmed cell death in the cyanobacterium Microcystis aeruginosa 显示文摘 | Ross C Santlago-V6zquez L Paul V | 2006 | Aquatic Toxicology2006，75，1： | 1 |
| 9 | Identification and characterisation of F3GT1 and F3GGT1, two glycosyltransferases responsible for anthocyanin biosynthesis in red‐fleshed kiwifruit (Actinidia chinensis)显示文摘 | MircoMontefiori Richard V.Espley DavidStevenson JanineCooney Paul M.Datson AnnaSaiz Ross G.Atkinson Roger P.Hellens Andrew C.Allan | 2010 | The Plant Journal2010，，1： | 1 |
| 10 | Bacteriocins:developing innate immunity for food显示文摘 | Paul D Cotter Colin Hill Paul Ross R | 2005 | Nature2005，，3： | 1 |
| 11 | Relationship between age, renal function and bone mineral density in the US population显示文摘 | Sidney Klawansky Eugene Komaroff Paul F. Cavanaugh David Y. Mitchell Matthew J. Gordon Janet E. Connelly Susan D. Ross | 2003 | Osteoporosis International2003，，7： | 1 |
| 12 | Laparoendoscopic single site (LESS) vs. conventional laparoscopic fundoplication for GERD: is there a difference?显示文摘 | Sharona Ross Andy Roddenbery Kenneth Luberice Harold Paul Thomas Farrior Michelle Vice Krishen Patel Alexander Rosemurgy | 2013 | Surgical Endoscopy2013，，2： | 1 |
| 13 | Lift- enhancing tabs on multi-element airfoil 显示文摘 | James C Ross Bruce L Storms Paul G Carrannanto | 1995 | Journal of Aircraft1995，23，3： | 1 |
| 14 | Humoral and cellular immune responses of pigs inoculated with Mycoplasma hyopneumoniae 显示文摘 | MESSIER S ROSS R F PAUL P S | 1990 | Am J Vet Res1990，51，1： | 1 |
| 15 | Toxin release in response to oxidative stress and programmed cell death in the cyanobacterium Microcystis aeruginosa 显示文摘 | Ross C Santiago-Vazquez L Paul V | 2006 | Aquat Toxico12006，78，1： | 1 |
| 16 | , DksA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTP显示文摘 | Paul BJ Barker M M Ross W et ai | 2004 | Cell2004，118，3： | 1 |
| 17 | Developing applications for lactococcal bacteriocins 显示文摘 | PAUL ROSS R MARY G OLIVIA M | 1999 | Antonie Van Leeuwenhoek1999，76，1： | 1 |
| 18 | CO2 storage and en- hanced coalbed methane recovery: reservoir characterization and fluid flow simulations of the Big George coal, Powder River Basin, Wyoming, USA 显示文摘 | Hannah E Ross Paul Hagin Mark D Zoback | 2009 | International Journal of Greenhouse Gas Con- trol2009，3，6： | 1 |
| 19 | Small tourism business networks and destination development 显示文摘 | ROSS TINSLEY PAUL LYNCH | 2001 | Hospitality Management2001，20，： | 1 |
| 20 | Guidance on the management of diarrhoea during cancer chemotherapy显示文摘 | Jervoise Andreyev Paul Ross Clare Donnellan Elaine Lennan Pauline Leonard Caroline Waters Linda Wedlake John Bridgewater Rob Glynne-Jones William Allum Ian Chau Richard Wilson David Ferry | 2014 | Lancet Oncology2014，，10： | 1 |
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