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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Frequency,risk factors, and outcome of hyperlactate mia after cardiac surgery 显示文摘 | Jean M Paul LB Manuel C | 2003 | CHEST2003，123，8： | 1 |
| 3 | Fenoldopam and Nacetylcysteine for the Prevention of Radiographic Contrast Material-Induced Nephropathy显示文摘 | Paul DW Kristi LB John CT | 2003 | Pharmacotherapy2003，23，： | 1 |
| 4 | Differences in depres- sion, anxiety, and quality of life between women with and without breast pain prior to breast cancer surgery 显示文摘 | Kyranou M Paul SM Dunn LB | 2011 | Eur Oncol Nurs2011，3，： | 1 |
| 5 | Differences in depression,anxiety,and quality of life between women with and without breastpain prior to breast cancer surgery 显示文摘 | Kyranou M Paul SM Dunn LB | 2013 | Eur Oncol Nurs2013，17，2： | 1 |
| 6 | Distal femoral allograft for mas sive proximal femoral deficiency显示文摘 | Robert LB Michael WW Paul M | 2000 | Acta Orthop Scand2000，71，1： | 1 |
| 7 | Fibroblast growth fac- tor-21 regulates PPAR3: acctivity and the antidiabetic actions of thiazolidinediones显示文摘 | Paul AD Takeshi K Angie LB | 2012 | CeU2012，148，3： | 1 |
| 8 | Differences in depres- sion, anxiety, and quality of life between women with and without breast pain prior to breast cancer surgery 显示文摘 | Kyranou M Paul SM Dunn LB eta! | 2013 | Euro- pean Journal of Oncology Nursing2013，17，2： | 1 |
| 9 | Fenoldopam and N -acetylcysteine for the prevention of radiographic contrast material-induced nephropathy:a review显示文摘 | Paul DW Pharm D Krisi LB | 2003 | Pharmacotherapy2003，23，12： | 1 |
| 10 | Instrument Scan Strategies of F-117A Pilots 显示文摘 | David LB Holly SV Paul AW | 2002 | Aviat Space Environ Med2002，73，10： | 1 |
| 11 | Widespread decreased expression of immune function genes in human peripheral blood following radiation exposure显示文摘 | Paul S Smilenov LB Amundson SA | 2013 | Radiat Res2013，180，6： | 1 |
| 12 | Prevalence of Hypertension in the U S Adult population 显示文摘 | Vicki LB Paul W Edward J | 1995 | Hypertension March1995，25，3： | 1 |
| 13 | Use of an intramedullary hip-screw compared with a compression hip-screw with a plate for intertrochanteric femoral fracture 显示文摘 | Dominique CR Pangiotis K Laurent F Paul S Catherine LB Philippe ED | 1998 | J Bone Joint Surg( Am)1998，80，： | 1 |
| 14 | Composition of extraction methods for quantifying extracellular polymers in biofilms 显示文摘 | Xiaoqi Zhang Paul LB Kinkle B | 1999 | Water Science and Technology1999，39，： | 1 |
| 15 | Differences in de- pression, anxiety, and quality of life between women with and without breast pain prior to breast cancer surgery显示文摘 | Kyranou M Paul SM Dunn LB | 2013 | European Journal of Oncology Nursing2013，17，2： | 1 |
| 16 | Distal femoral allograft for mas sive proximal femoral deficiency 显示文摘 | Robert LB Michael WW Paul M | 2008 | Acta Orthop Scand2008，7，1： | 1 |
| 17 | Potent inhibition of respiratory syncytial virus replication using a 2-5A-antisense chimera targeted to signals within the virus genomic RNA显示文摘 | Mark RP Dale LB Paul FT | 1998 | Proc Natl Acad Sci U S A1998，95，15： | 1 |
| 18 | ?(ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury) 显示文摘 | Naga PC Paul HH Herbert LB | 2014 | Am J Gastroenterol2014，131，： | 1 |
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